Cynfo (500mg) 10 Capsules

Fosfomycin, the active ingredient in Fosfomycin 500mg Capsules, exhibits a unique mechanism of action by primarily inhibiting the initial stage of bacterial cell wall synthesis. It specifically targets the enzyme enolpyruvyl transferase, which is crucial for the formation of the peptidoglycan layer in bacterial cell walls. By binding to this enzyme, fosfomycin disrupts the synthesis of the peptidoglycan, a vital structural component of the bacterial cell wall. This inhibition leads to the weakening and eventual rupture of the cell wall, resulting in bacterial cell death. The distinctive mechanism of fosfomycin allows it to exert broad-spectrum activity against various Gram-positive and Gram-negative bacteria, making it effective in treating a range of infections.

Fosfomycin 500mg

Fosfomycin is an Antibiotic.

Capsule

The following are the uses of Fosfomycin 500mg Capsule:

• Used for treating uncomplicated lower urinary tract infections caused by susceptible bacteria.
• Used for the treatment of bacterial infections in the bladder.
• Used to eliminate bacteria causing infections like E. coli and Enterococcus.
• Used for acute prostatitis and bacterial infections in the prostate gland.
• Used for preventing infections during surgical procedures in the urinary system.
• Used for treating bone and joint infections caused by susceptible bacteria.
• Used for its ability to disrupt bacterial cell wall synthesis, making it effective against a range of pathogens.

In the case of an overdose of Fosfomycin 500mg Capsules, individuals may experience an increase in the severity of common side effects such as gastrointestinal disturbances, including nausea, vomiting, and diarrhea. Additionally, there is a potential risk of developing more serious symptoms, such as severe allergic reactions, which may require prompt medical intervention. It is crucial to seek medical advice immediately if an overdose is suspected to prevent potential complications and ensure appropriate treatment.

In the case of a missed dose of Fosfomycin 500mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure you complete the full course of treatment effectively.

To take Fosfomycin 500mg Capsule, swallow the capsule whole with a full glass of water, ensuring you do not break or chew the capsule, as directed by your healthcare provider, typically once every 48 to 72 hours or as prescribed.

Following are the conditions when Fosfomycin 500mg Capsule should not be taken:

• Should not be taken if you have a known allergy or hypersensitivity to fosfomycin or any other ingredients in the formulation.
• Contraindicated in patients with severe kidney impairment (kidney failure) as it may require dosage adjustments or alternative treatment.
• Not recommended for children below 12 years of age due to limited data on safety and efficacy.
• Avoid using if you have a history of gastrointestinal diseases or conditions that may affect drug absorption.
• Should not be taken if you have a history of urinary tract obstruction or structural abnormalities.
• Fosfomycin is not recommended for long-term use, as prolonged use may lead to bacterial resistance.

The side effects of Fosfomycin 500mg Capsule may include:

• Diarrhea
• Nausea and vomiting
• Abdominal pain or cramps
• Headache
• Dizziness
• Vaginal itching or discharge
• Skin rash or itching
• Allergic reactions (such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat)

Following are the precautions and warnings for Fosfomycin 500mg Capsule:

• Not recommended for individuals with known allergies to fosfomycin or other ingredients in the capsule.
• Patients with a history of kidney disease should exercise caution, as dosage adjustments may be necessary.
• Avoid concurrent use with other antibiotics without medical supervision to prevent potential drug interactions.
• Fosfomycin may cause diarrhea; if it becomes severe or persistent, stop taking the medication and consult a doctor.
• Not suitable for children under 12 years old unless prescribed by a healthcare professional.
• Exercise caution in patients with a history of gastrointestinal disorders as it may exacerbate these conditions.
• Consult a healthcare provider before using Fosfomycin if you are pregnant, breastfeeding, or planning to become pregnant.
• Do not exceed the prescribed dosage, as this may increase the risk of side effects and bacterial resistance.

Following are the drug interactions for Fosfomycin 500mg Capsule:

• Probenecid can increase the concentration of Fosfomycin, potentially leading to enhanced side effects.
• Fosfomycin may reduce the absorption of tetracyclines, making them less effective.
• Antacids containing aluminum, magnesium, or calcium can decrease the absorption of Fosfomycin, and should be taken at different times.
• Concomitant use with other antibiotics like chloramphenicol or aminoglycosides may result in altered efficacy or increased side effects.
• Oral anticoagulants like warfarin may have their effect enhanced by Fosfomycin, requiring close monitoring of coagulation parameters.
• Methotrexate levels can be increased by Fosfomycin, potentially leading to increased toxicity.
• Drugs primarily eliminated by kidney excretion may have their elimination reduced by Fosfomycin, requiring dose adjustments.

Following are the food interactions for Fosfomycin 500mg Capsule:

• Fosfomycin should be taken on an empty stomach, at least 2 hours before or after meals, as food can decrease its absorption.
• Avoid consuming dairy products like milk, cheese, or yogurt within 1-2 hours of taking Fosfomycin, as calcium can bind to the medication and reduce its effectiveness.
• Stay well-hydrated and drink plenty of fluids while taking this medication, but avoid consuming alcohol as it may exacerbate side effects.
• Grapefruit and grapefruit juice should be consumed with caution, as they may increase the levels of Fosfomycin in the body, potentially leading to higher risks of side effects.
• Avoid high-fiber foods like whole grains, beans, and certain vegetables just before or after taking the medication, as fiber can interfere with the absorption of Fosfomycin.
• Certain iron-rich foods like red meat, liver, and iron-fortified cereals can decrease the absorption of Fosfomycin, so it's best to separate their consumption by a few hours.
• Avoid taking Fosfomycin with antacids containing magnesium or aluminum, as these can reduce the effectiveness of the antibiotic.
• Always take Fosfomycin as directed by your healthcare provider, and ensure you complete the full course of treatment to prevent antibiotic resistance.

Fosfomycin 500mg Capsules should be stored in a cool and dry place, preferably at room temperature (68°F to 77°F). Keep the capsules in their original packaging, tightly sealed, to protect them from moisture and light. It is crucial not to store them in the bathroom or kitchen, as these areas may have high humidity or temperature fluctuations. Always check the expiration date before using any medication, and discard any expired or unused capsules. Proper disposal is essential; do not flush them down the toilet or throw them into the trash. Consult your pharmacist or healthcare provider for guidance on safe disposal methods. Keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Fosfomycin 500mg Capsule:

• Take the capsule as directed by your doctor, typically as a single dose or as prescribed.
• Swallow the capsule whole with a full glass of water; do not crush or chew.
• Fosfomycin is best taken on an empty stomach, at least 2 hours before or after a meal.
• Avoid taking antacids or dairy products within 2 hours of taking the medication.
• Complete the full course of medication, even if you feel better after a few days.
• Stay well-hydrated while taking this medication.
• Store the capsules at room temperature, away from moisture and light.