CYTOSAR 100MG INJ

Cytarabine, also known as cytosine arabinoside, is a chemotherapy medication that exerts its anti-cancer effects by interfering with DNA synthesis. Its mechanism of action primarily involves inhibiting DNA polymerase, an enzyme crucial for DNA replication. Cytarabine is a nucleoside analog that mimics the structure of a natural nucleoside, cytosine. Once inside cancer cells, cytarabine is converted into its active form, cytarabine triphosphate. This active metabolite competes with the natural nucleoside and gets incorporated into the growing DNA strands, leading to the disruption of DNA synthesis. As a result, it causes DNA strand breakage and triggers programmed cell death (apoptosis) in rapidly dividing cancer cells, effectively halting their growth and proliferation.

Cytarabine 100MG

Antimetabolite/Anticancer

Injection

The following are the uses of Cytarabine 100MG Injection:

• Used for treating acute myeloid leukemia, offering a powerful chemotherapy option.
• Used for combating acute lymphoblastic leukemia, providing targeted treatment.
• Used in the management of lymphomas, helping to shrink and control cancerous growth.
• Used to suppress the overactive bone marrow in myeloproliferative disorders.
• Used for managing certain types of brain tumors, offering a crucial treatment approach.
• Used in stem cell transplant procedures to prepare the body for new cells.
• Used as a life-saving intervention for aggressive blood cancers.
• Used in combination with other drugs for comprehensive cancer care.

In the case of an overdose of Cytarabine 100MG Injection, prompt medical attention is necessary. Symptoms of an overdose may include severe nausea, vomiting, diarrhea, and potential neurological effects such as dizziness, confusion, or seizures. The severity of these symptoms can vary based on the amount ingested and individual sensitivity. Immediate treatment should focus on managing these symptoms, providing supportive care, and ensuring the patient's vital signs are monitored until medical assistance arrives.

In the case of a missed dose of Cytarabine 100MG Injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the medication as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to proceed with your treatment plan.

To administer Cytarabine 100MG Injection, under aseptic conditions, reconstitute the vial with the appropriate diluent, gently swirl the vial to dissolve the medication completely, and then inject the prescribed dose intravenously or intrathecally as directed by your healthcare professional, ensuring proper handling and disposal of the injection materials.

Following are the conditions or circumstances when Cytarabine 100MG Injection should not be administered:

• Must not be used in patients with a known hypersensitivity or severe allergic reaction to Cytarabine or similar medications.
• Not recommended for individuals with severely decreased bone marrow function, as it can further suppress bone marrow activity.
• Should be avoided in patients with advanced kidney disease or severe renal impairment, as dosage adjustments may be difficult.
• Contraindicated in patients with a history of severe liver disease or significant hepatic impairment.
• Not suitable for patients with a history of serious brain or central nervous system disorders.
• Should not be used in pregnant women due to potential harm to the fetus.
• Breastfeeding mothers should not use Cytarabine as it may pass into breast milk and harm the nursing infant.
• This medication is not recommended for patients with a history of severe systemic infections or uncontrolled active infections.

The side effects of Cytarabine 100MG Injection may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Mouth sores
• Skin rash or itching
• Fatigue and weakness
• Hair loss
• Increased risk of infection

Following are the precautions and warnings for Cytarabine 100MG Injection:

• This medication is for intravenous or intrathecal use only and should be administered under strict medical supervision.
• Not recommended for patients with a history of hypersensitivity or severe allergic reactions to Cytarabine or any of its components.
• Cytarabine can cause bone marrow suppression, leading to decreased blood cell counts. Regular monitoring of blood cell counts is essential during treatment.
• Patients with pre-existing kidney or liver disease should use Cytarabine with caution as it may worsen these conditions.
• Elderly patients may be more susceptible to the side effects of this medication; dosage adjustments might be necessary.
• It is important to avoid pregnancy during and after treatment with Cytarabine, as it may cause harm to the fetus. Effective contraception is recommended.
• Patients should be monitored for signs of infection, as Cytarabine can increase the risk of developing severe infections.
• Discontinue the medication and seek medical attention if any severe or persistent side effects occur, such as severe nausea, vomiting, or neurological symptoms.

Following are the drug interactions for Cytarabine 100MG Injection:

• Co-administration with phenytoin or phenobarbital may reduce the efficacy of Cytarabine due to increased metabolism.
• Drug interactions with concurrent use of radiation therapy or other antineoplastic agents may increase toxicity.
• The risk of myelosuppression is heightened when used with other myelosuppressive drugs.
• Concomitant use with allopurinol may result in increased bone marrow toxicity.
• Care should be taken when using with drugs that affect renal function, as Cytarabine is renally eliminated.
• Probenecid can decrease the renal tubular secretion of Cytarabine, potentially increasing its effects.
• Live virus vaccines should not be administered during and after Cytarabine therapy due to potential hazards.

Following are the food interactions to consider with Cytarabine 100MG Injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of liver damage and worsen side effects like nausea and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of the medication, leading to increased levels of Cytarabine in the body.
• High-fat meals may delay the absorption of Cytarabine, so it is advisable to take the medication on an empty stomach or as directed by your healthcare professional.
• Avoid consuming large amounts of cranberry products as they may alter the effectiveness of the medication by affecting its metabolism.
• Limit the consumption of foods rich in tyramine (aged cheeses, cured meats, fermented foods) as Cytarabine may impact tyramine metabolism, potentially leading to increased blood pressure.
• Avoid or limit caffeine intake as Cytarabine may prolong the effects of caffeine, resulting in increased heart rate and blood pressure.
• Follow a balanced diet and stay hydrated to support overall health during treatment, ensuring adequate nutrient intake and fluid balance.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Cytarabine 100MG Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. It is crucial to maintain a consistent temperature, typically between 68°F to 77°F (20°C to 25°C), to ensure the medication's stability. The injection should be kept in its original packaging, tightly sealed, to prevent contamination and maintain its integrity. Do not freeze the medication as it may affect its potency. When disposing of Cytarabine, do not throw it into the trash or pour it down the drain. Contact your healthcare provider or pharmacist for instructions on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Cytarabine 100MG Injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is prepared and handled by trained medical personnel.
• Cytarabine is typically given in a clinical setting; follow the prescribed treatment schedule.
• Do not reuse or share needles/syringes; dispose of properly after use.
• Inform your doctor if you experience any side effects, especially severe ones like fever or chills.
• Maintain good hygiene practices during treatment to minimize infection risks.
• Regularly monitor your blood counts and overall health during the treatment period.