D-Cure (25000IE) 12 Ampoule Injections

Cholecalciferol 25,000 IU injection acts primarily by binding to the vitamin D receptor (VDR) in various target tissues. Once bound, it forms a complex that regulates gene expression, influencing calcium and phosphate metabolism. Cholecalciferol promotes intestinal absorption of calcium and phosphate, mobilizes calcium from bone, and enhances renal tubular reabsorption of calcium, thereby maintaining serum calcium and phosphate levels. It also plays a role in immune function modulation and cell proliferation.

Cholecalciferol 25,000iu

Vitamin D analog

Injection

The following are the uses of Cholecalciferol 25,000iu injection:

• Used for treating Vitamin D deficiency, especially in patients with malabsorption syndromes.
• Used for bone health, aiding in calcium absorption and maintaining bone density.
• Used for managing hypocalcemia, a condition of low calcium levels in the blood.
• Used for supporting immune function and overall health.
• Used for preventing and treating rickets, a disease caused by Vitamin D deficiency.
• Used for assisting in the treatment of osteoporosis, promoting bone strength.
• Used for certain skin conditions, as prescribed by a healthcare professional.
• Used for general well-being and as a supplement during periods of limited sun exposure.

In the case of an overdose of Cholecalciferol 25,000 IU injection, symptoms may include nausea, vomiting, weakness, headache, and a rapid or irregular heartbeat. High calcium levels in the blood can lead to serious complications such as kidney damage, dehydration, and even heart or brain issues. Seek medical attention immediately if an overdose is suspected, as prompt treatment can help prevent severe health consequences. Timely intervention and medical support are crucial in managing potential toxicity.

In the case of a missed dose of Cholecalciferol 25,000 IU injection, it is important to follow the healthcare provider's instructions. If you realize you've missed a dose, administer it as soon as possible, but avoid doubling the dose to catch up. If it's almost time for your next scheduled dose, simply skip the missed dose and continue with your regular dosing schedule. However, if you frequently miss doses, inform your healthcare provider, as they may need to adjust your dosage or provide guidance on managing missed doses.

To administer Cholecalciferol 25,000 IU injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the entire content of the vial subcutaneously or intramuscularly as directed by your healthcare provider, ensuring proper needle disposal afterward.

Here are the conditions and situations when Cholecalciferol 25,000 IU injection should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to Cholecalciferol or any of its excipients.
• Contraindicated in patients with hypervitaminosis D (excessive vitamin D levels in the body).
• Should not be used in individuals with hypercalcemia (high blood calcium levels) or conditions causing hypercalcemia, such as sarcoidosis, bone metastases, or Williams syndrome.
• Not suitable for patients with renal stones or impaired renal function.
• Should be avoided in individuals with conditions causing hyperphosphatemia (high phosphate levels in the blood).
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Not recommended for breastfeeding mothers, as vitamin D can pass into breast milk.
• Should not be used in infants or children as a high dose, except under medical supervision for specific conditions.
• Avoid using in patients with atherosclerosis or cardiovascular disease, as high doses of vitamin D may increase the risk of vascular calcification.
• Not suitable for individuals with hyperparathyroidism.
• Should be used with caution in patients with immobility or prolonged bed rest, as they may be at higher risk of complications.

The side effects of Cholecalciferol 25,000 IU injection may include:

• Nausea and vomiting
• Weakness and fatigue
• Loss of appetite
• Dry mouth
• Metallic taste
• Increased thirst and urination
• Muscle or bone pain
• Itching or rash

Following are the precautions and warnings for Cholecalciferol 25,000 IU injection:

• Do not use if you have a known allergy or hypersensitivity to cholecalciferol or any of the excipients in the injection.
• Use with caution in patients with kidney problems as it may lead to hypercalcemia and hypercalciuria. Regular monitoring is necessary.
• Prolonged use of high doses can result in an excessive increase in vitamin D levels, leading to hypercalcemia and its associated symptoms. Monitor calcium levels regularly.
• Cholecalciferol may increase calcium levels, which can have cardiovascular implications. Use with caution in patients with a history of heart disease.
• Monitor electrolyte levels, especially in patients with kidney issues, as cholecalciferol can affect calcium and phosphate balance.
• Exercise caution in the elderly due to the increased risk of hypercalcemia and the potential for drug interactions with other medications they may be taking.
• Consult a healthcare professional before use during pregnancy or while breastfeeding to ensure the benefits outweigh the risks.

Following are the drug interactions for Cholecalciferol 25,000 IU injection:

• Anticonvulsants like phenobarbital, phenytoin, or carbamazepine may reduce the effectiveness of Cholecalciferol by increasing its metabolism.
• Cholestyramine and colestipol can bind to Cholecalciferol in the digestive tract, reducing its absorption. Separate their administration by at least 4 hours.
• Orlistat, a weight-loss medication, can decrease the absorption of fat-soluble vitamins like Cholecalciferol. Consider alternative vitamin D supplementation.
• Thiazide diuretics (e.g., hydrochlorothiazide) may increase the risk of hypercalcemia when used with Cholecalciferol, especially in patients with renal impairment.
• Vitamin D levels should be monitored when taking corticosteroids long-term, as they can decrease calcium absorption and increase vitamin D metabolism.
• Calcium supplements may compete for absorption with Cholecalciferol, so they should be taken at different times of the day.
• Drugs that can increase the sensitivity to sunlight, such as thiazide diuretics, phenothiazines, and tetracyclines, may increase the risk of sunburn when used with Cholecalciferol.

Following are the food interactions for Cholecalciferol 25,000 IU injection:

• High-fat diets can interfere with vitamin D absorption, as vitamin D is a fat-soluble vitamin. It is best to maintain a balanced diet.
• Avoid excessive intake of vitamin D-fortified foods or supplements, as this medication already provides a high dose of vitamin D.
• Consuming calcium-rich foods like dairy products, leafy greens, and fortified foods can support the effectiveness of Cholecalciferol in maintaining bone health.
• Fish, such as salmon and mackerel, are rich in vitamin D and can enhance the effects of the injection.
• Avoid excessive sun exposure, as it can lead to an increased risk of vitamin D toxicity when combined with the injection.
• Limit caffeine intake, as it may interfere with calcium absorption, which is essential for vitamin D's bone-strengthening effects.
• Avoid alcohol, as it can impair the liver's ability to metabolize vitamin D, potentially leading to imbalances.
• Certain medications, like antacids containing magnesium, can interact with vitamin D absorption; consult your healthcare provider for guidance.

Cholecalciferol 25,000iu injection should be stored in a controlled environment, specifically at room temperature (20-25°C/68-77°F) with protection from light and moisture. It is crucial to keep the injection in its original packaging, ensuring the seal remains intact to maintain sterility. Avoid exposing the injection to extreme temperatures, including freezing or excessive heat, as it may compromise its effectiveness. When disposing of unused or expired injections, do not dispose of them via household waste or wastewater. Instead, follow local guidelines for pharmaceutical waste disposal or consult healthcare professionals for appropriate methods. Always keep medications, including this injection, out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Cholecalciferol 25,000iu injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm the correct dosage as prescribed by your doctor.
• Relax and stay still during the injection process.
• Report any discomfort, redness, or swelling at the injection site to your healthcare provider.
• Maintain a healthy diet rich in vitamin D sources.
• Consider sunlight exposure for natural vitamin D synthesis.
• Regularly monitor your vitamin D levels as advised by your doctor.
• Store the injection as directed, away from direct sunlight and moisture.