D-Gest (10mg) 20 Tablets

Dydrogesterone is a synthetic progestogen that mimics the action of the natural hormone, progesterone. Its primary mechanism of action is through binding to progesterone receptors in the body, particularly in the uterus. By activating these receptors, dydrogesterone exerts its effects on the endometrium, causing it to undergo secretory changes and promoting the development of a healthy endometrial lining. This action helps regulate the menstrual cycle and supports pregnancy by preparing the uterine lining for implantation and maintaining a supportive environment for the developing embryo. The selective binding of dydrogesterone to progesterone receptors gives it a specific and targeted effect on the endometrium, making it useful in various gynecological conditions where progesterone supplementation is required.

Dydrogesterone

Progestogen.

Tablet

The following are the uses of Dydrogesterone Tablet:

• Used for treating irregular menstrual cycles and restoring normal ovulation.
• Used for managing premenstrual syndrome (PMS) and alleviating associated symptoms.
• Used for supporting pregnancy by supplementing natural progesterone levels.
• Used for treating endometriosis, reducing pain, and managing symptoms.
• Used for treating dysfunctional uterine bleeding and regulating menstrual flow.
• Used for contraception in combination with estrogen, providing a progestational effect.
• Used for preparing the uterus for pregnancy in assisted reproductive technologies.
• Used for managing menopausal symptoms, especially in hormone replacement therapy.

In the case of an overdose of Dydrogesterone Tablets, it is important to seek medical advice promptly. Overdosing may lead to symptoms such as nausea, dizziness, and headache. The severity of symptoms can vary depending on the amount ingested. If a person suspects an overdose, they should contact a healthcare professional or a poison control center for guidance. Prompt medical assessment and treatment can help manage any adverse effects and ensure the individual's well-being.

In the case of a missed dose of Dydrogesterone Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely adjust your medication routine. It is advisable to set reminders or use a pill organizer to help you remember to take your medication on time.

To take Dydrogesterone Tablets, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Dydrogesterone Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Dydrogesterone or other similar progestogens.
• Contraindicated in women who are pregnant, especially during the first trimester.
• Not suitable for individuals with a history of thromboembolic disorders or active thrombophlebitis (blood clots).
• Should not be used in patients with severe liver impairment or liver disease.
• Not recommended for women with undiagnosed vaginal bleeding or endometrial hyperplasia.
• Contraindicated in individuals with breast cancer or a history of breast cancer, as it may stimulate hormone-responsive tissues.
• Should be avoided in patients with porphyria, a rare metabolic disorder.
• Not suitable for those with a history of stroke or cardiovascular diseases.
• Should not be used for contraception in women with acute or recent history of liver disease or liver tumors.

The side effects of Dydrogesterone Tablet may include:

• Skin rashes or itching
• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Fatigue or weakness
• Headache
• Breast tenderness
• Changes in menstrual bleeding patterns

Following are the precautions and warnings for Dydrogesterone Tablets:

• This medication is not intended for use in cases of confirmed or suspected estrogen-dependent cancers, including breast cancer, as it may stimulate tumor growth.
• Patients with a history of or active thrombosis or thromboembolic disorders, such as blood clots, should not take Dydrogesterone.
• It is not recommended for individuals with a history of or active liver disease, as it may exacerbate liver-related conditions.
• Dydrogesterone may cause fluid retention, so caution is advised in patients with heart or kidney problems, and those with epilepsy or asthma.
• This medication can lead to changes in vaginal bleeding patterns, and any irregular bleeding should be reported to a healthcare professional.
• Not suitable for use in cases of undiagnosed vaginal bleeding; proper medical evaluation is necessary before starting treatment.
• Dydrogesterone may cause skin reactions; any severe skin reactions or allergies should be reported to a doctor immediately.
• This medication may impact blood glucose levels, so patients with diabetes should monitor their blood sugar closely.

Following are the drug interactions for Dydrogesterone Tablet:

• Concurrent use with strong CYP3A4 inducers like rifampicin or St. John's Wort may reduce the effectiveness of dydrogesterone.
• Dydrogesterone can increase the effects of corticosteroids, requiring careful monitoring and adjustment of doses.
• The efficacy of dydrogesterone may be reduced when used with strong CYP3A4 inhibitors such as ketoconazole or ritonavir.
• The risk of thrombosis may be increased when combined with estrogen-containing medications.
• Caution is advised when using dydrogesterone with antidiabetic medications, as it may alter glucose metabolism.
• It may interact with antiepileptic drugs, potentially reducing their effectiveness.
• Dydrogesterone can affect the metabolism of other drugs metabolized by CYP3A4, requiring close observation for dose adjustments.

Following are the food interactions to be aware of when taking Dydrogesterone Tablets:

• Avoid consuming grapefruit or grapefruit juice as they can interfere with the metabolism of Dydrogesterone, potentially leading to increased drug levels in the body.
• Limit alcohol consumption as it may enhance the sedative effects of Dydrogesterone, increasing the risk of dizziness and drowsiness.
• There is no specific requirement to take this medication with or without food, but maintaining a consistent routine is advisable.
• High-fat meals may slightly delay the absorption of Dydrogesterone, but this is generally not a significant concern.
• Avoid excessive caffeine intake as it can potentially interact with Dydrogesterone, affecting hormone levels.
• Be cautious with herbal supplements, especially those containing St. John's Wort, as they may alter the drug's effectiveness.
• Always inform your healthcare provider about your dietary habits to ensure safe and effective medication use.
• Maintain a balanced diet to support overall health while taking Dydrogesterone.

Dydrogesterone Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to keep the tablets, maintaining their integrity and preventing contamination. It's crucial to avoid exposing the medication to extreme temperatures, so steer clear of storing it in bathrooms or near heat sources like ovens or radiators. Always be mindful of the expiration date on the packaging, and when disposing of unused or expired tablets, refrain from flushing them down the toilet or pouring them into drains. Consult a pharmacist or healthcare professional for appropriate disposal methods, and keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Dydrogesterone Tablet:

• Take the tablet as directed by your doctor, typically with or after meals.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Maintain a consistent daily dosage schedule to ensure the best results.
• If you experience nausea, taking the tablet with food can help alleviate symptoms.
• Avoid missing doses; if you miss one, consult your doctor for advice on catching up.
• Do not double the dose to make up for a missed one; it may increase side effect risks.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.