Din (40mg) 2ml Injection

Cholecalciferol, also known as vitamin D3, has a straightforward mechanism of action when administered as a 400 IU injection. It primarily acts as a prohormone, meaning it is converted into active forms within the body. Upon injection, cholecalciferol is absorbed into the bloodstream, where it undergoes two sequential hydroxylations. First, it is converted to 25-hydroxyvitamin D (calcidiol) in the liver, and then further metabolized in the kidneys to form 1,25-dihydroxyvitamin D (calcitriol), the active form of vitamin D. Calcitriol binds to vitamin D receptors (VDRs) in various target tissues, influencing gene expression. This process regulates calcium and phosphate metabolism by promoting intestinal calcium and phosphate absorption, stimulating osteoclast-mediated bone resorption, and enhancing renal reabsorption of calcium, thereby contributing to the maintenance of calcium homeostasis and bone health.

Cholecalciferol 400iu

Vitamin D3 analog

Injection

The following are the uses of Cholecalciferol 400iu injection:

• Used for treating and preventing vitamin D deficiency, ensuring proper calcium absorption for healthy bones.
• Used for managing conditions like rickets and osteomalacia, where vitamin D levels are critically low.
• Used to support bone health in individuals with limited sun exposure or certain medical conditions affecting vitamin D production.
• Used in the treatment of chronic kidney disease to regulate calcium and phosphate levels.
• Used to enhance calcium absorption in individuals with malabsorption syndromes.
• Used to prevent falls and fractures in older adults by maintaining bone strength.
• Used as a supplement during pregnancy and breastfeeding to meet increased vitamin D needs.
• Used in conjunction with other medications to manage various bone-related disorders.

In the case of an overdose of Cholecalciferol 400IU injection, prompt medical attention is required. Symptoms may include nausea, vomiting, constipation, weakness, and elevated calcium levels in the blood. Treatment involves managing the symptoms and providing supportive care. It is important to seek medical assistance immediately if an overdose is suspected, as this can lead to serious health complications. The medical team will assess the situation and provide the necessary treatment to address the overdose.

In the case of a missed dose of Cholecalciferol 400iu injection, it is generally recommended to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, it is advisable to skip the missed dose and continue with the regular dosing schedule. It is crucial not to double the dose to make up for a missed one, as this may lead to potential side effects. If you have any concerns or questions regarding missed doses, it is best to consult your healthcare provider for specific guidance. They can provide personalized advice based on your medical history and current health status.

To administer Cholecalciferol 400iu injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire dose is delivered, and then safely dispose of the used needle and syringe.

Here are the conditions or situations when Cholecalciferol 400iu injection should not be used:

• Avoid using if the patient has a known hypersensitivity or allergy to Cholecalciferol or any of the excipients in the injection.
• Not recommended for individuals with hypervitaminosis D (excessive levels of vitamin D in the body).
• Contraindicated in patients with hypercalcemia (high calcium levels in the blood) or conditions that lead to elevated calcium levels, such as primary hyperparathyroidism.
• Should not be used in patients with kidney stones or conditions that increase the risk of developing kidney stones, such as hypercalciuria (high levels of calcium in the urine).
• Avoid using in individuals with conditions causing calcium mobilization from bones, such as certain types of tumors or Paget's disease.
• Not suitable for patients with impaired kidney function or kidney disease.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Should not be used in breastfeeding women, as vitamin D can pass into breast milk and may affect the nursing infant.

The side effects of Cholecalciferol 400iu injection may include:

• Weakness or fatigue
• Nausea and vomiting
• Loss of appetite
• Dry mouth
• Metallic taste in the mouth
• Constipation or diarrhea
• Muscle or joint pain
• Increased thirst

Following are the precautions and warnings for Cholecalciferol 400iu injection:

• Allergic reactions may occur; seek medical attention if you experience symptoms like rash, itching, swelling, or difficulty breathing.
• Not recommended for individuals with hypervitaminosis D or those with a known sensitivity to vitamin D.
• Should be used with caution in patients with kidney stones, kidney disease, or conditions affecting calcium metabolism.
• Regular monitoring of calcium and phosphate levels is essential during prolonged treatment.
• May cause hypercalcemia, especially in patients with immobility, heart disease, or kidney issues; monitor for symptoms like nausea, vomiting, and constipation.
• Ensure adequate hydration and avoid excessive sunlight exposure during treatment.
• Inform your doctor about all medications you are taking, especially those affecting calcium levels.
• Keep out of reach of children, and store at room temperature, away from direct light.

Following are the drug interactions for Cholecalciferol 400 IU injection:

• Anticonvulsants like phenytoin and phenobarbital may reduce the effectiveness of cholecalciferol by increasing its metabolism.
• Cholestyramine and colestipol can decrease the absorption of cholecalciferol by binding to it in the intestine.
• Orlistat, a weight-loss medication, can reduce the absorption of fat-soluble vitamins like cholecalciferol.
• Thiazide diuretics may increase calcium levels, and concurrent use with cholecalciferol can further elevate calcium levels.
• Corticosteroids such as prednisone may increase the breakdown of vitamin D, requiring higher doses of cholecalciferol.
• Aluminum-containing antacids can decrease the absorption of cholecalciferol by forming insoluble complexes.
• Mineral oil laxatives may interfere with the absorption of fat-soluble vitamins, including cholecalciferol.

Following are the food interactions for Cholecalciferol 400iu injection:

• Consuming foods rich in Vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, can lead to excessive Vitamin D levels when combined with the injection.
• Grapefruit and its juice should be limited as they may influence the metabolism of Vitamin D, potentially affecting blood levels.
• Alcohol intake should be minimized as it can interfere with Vitamin D metabolism and absorption, reducing its effectiveness.
• Avoid high-fat meals as they may temporarily reduce the absorption of Vitamin D, impacting the injection's efficacy.
• Calcium-rich foods like dairy products, leafy greens, and fortified foods should be consumed in moderation to prevent excessive calcium levels when combined with the injection.
• Phosphorus-rich foods such as meat, poultry, and whole grains should be balanced in the diet to maintain proper mineral levels while on this treatment.
• Magnesium-rich foods including nuts, seeds, and whole grains can be beneficial as they aid in Vitamin D metabolism and bone health.
• Stay well-hydrated, as dehydration can affect kidney function, which is crucial for Vitamin D metabolism.

Cholecalciferol 400iu injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The injection should be kept in its original packaging, ensuring the container is tightly sealed to maintain its sterility. It is crucial to store the medication at room temperature, avoiding exposure to extreme heat or cold. Regularly check the expiration date on the packaging, and discard any expired or unused injections promptly. When disposing of Cholecalciferol 400iu injection, do not flush it into the sewage system or pour it down the drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult healthcare professionals for appropriate methods to ensure safe and environmentally friendly disposal. Keep the medication securely stored, out of the reach of children, to prevent accidental exposure or ingestion.

Following are the quick tips for Cholecalciferol 400iu injection:

• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before the injection.
• Relax and stay still during the injection process for a more comfortable experience.
• Keep the injection site clean and dry after the procedure.
• Report any persistent pain, swelling, or redness at the injection site to your doctor.
• Avoid missing doses to maintain consistent vitamin D levels.
• Store the injection as directed on the package, away from direct sunlight and moisture.