D-Zon (200000IU) 1 Oral Solution

Cholecalciferol, also known as vitamin D3, has a specific mechanism of action when administered as a 200,000 IU solution. Upon absorption, cholecalciferol undergoes two sequential hydroxylations in the body. First, it is converted to 25-hydroxycholecalciferol (calcidiol) in the liver, and then to its active form, 1,25-dihydroxycholecalciferol (calcitriol), primarily in the kidneys. Calcitriol binds to the vitamin D receptor (VDR) found in various tissues, including the intestines, bones, and parathyroid glands. This binding triggers a cascade of cellular responses. In the intestines, it enhances the absorption of calcium and phosphorus, promoting bone mineralization. Calcitriol also regulates parathyroid hormone (PTH) secretion, which in turn controls calcium and phosphorus homeostasis. By modulating these processes, cholecalciferol plays a crucial role in maintaining optimal bone health and calcium balance.

Cholecalciferol 200,000iu

Vitamin D

Solution

The following are the uses of Cholecalciferol 200,000iu Solution:

• Used for treating Vitamin D deficiency, ensuring proper bone development and preventing conditions like rickets.
• Used to support calcium absorption, vital for maintaining strong and healthy bones.
• Used in the management of osteoporosis, helping to reduce the risk of bone fractures.
• Used to regulate the immune system, playing a role in overall immune health.
• Used to enhance muscle strength and improve physical performance.
• Used to potentially lower the risk of certain cancers by promoting cellular health.
• Used for overall well-being, as Vitamin D is essential for various bodily functions.

In the case of an overdose of Cholecalciferol 200,000 IU Solution, symptoms may include nausea, vomiting, constipation, loss of appetite, weakness, and kidney problems. The severity of these symptoms can vary depending on the amount ingested. If an overdose is suspected, it is important to seek medical advice promptly. Treatment may involve managing symptoms and providing supportive care, with the aim of minimizing the potential harm caused by the excessive intake of this medication.

In the case of a missed dose of Cholecalciferol 200,000 IU Solution, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely adjust your dosing schedule.

To take Cholecalciferol 200,000 IU Solution, administer the entire contents of the single-use vial orally, preferably with a meal, or as directed by your healthcare professional, ensuring you follow the prescribed dosage instructions provided.

Following are the conditions or situations when Cholecalciferol 200,000 IU Solution should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to Cholecalciferol or any of its excipients.
• Contraindicated in patients with hypervitaminosis D (excessive vitamin D levels in the body).
• Not recommended for individuals with hypercalcemia (high blood calcium levels) or conditions that cause elevated calcium levels, such as sarcoidosis or Williams syndrome.
• Should not be used in patients with kidney stones or a history of kidney disease.
• Contraindicated in individuals with conditions causing hypercalciuria (high calcium levels in urine) or impaired calcium metabolism.
• Not suitable for those with atherosclerosis (hardening of the arteries) or evidence of vascular calcification.

The side effects of Cholecalciferol 200,000 IU Solution may include:

• Nausea and vomiting
• Weakness and fatigue
• Loss of appetite
• Dry mouth
• Metallic taste
• Constipation or diarrhea
• Excessive thirst
• Muscle or bone pain

Following are the precautions and warnings for Cholecalciferol 200,000iu Solution:

• Allergic reactions may occur; discontinue use if signs of allergy develop.
• Not recommended for individuals with hypervitaminosis D or conditions causing elevated calcium levels.
• Monitor calcium levels regularly during long-term therapy, especially in patients with kidney disease.
• May cause dizziness; caution is advised when performing tasks requiring alertness.
• Use with caution in patients with a history of kidney stones or kidney disease.
• Consult a doctor before use if you have any cardiovascular issues or a history of heart disease.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Cholecalciferol 200,000 IU Solution:

• Anticonvulsants like phenobarbital, phenytoin, or carbamazepine can reduce the effectiveness of Cholecalciferol by increasing its metabolism.
• Thiazide diuretics may enhance the effect of vitamin D, potentially leading to hypercalcemia.
• Orlistat and cholestyramine can decrease the absorption of vitamin D.
• Calcium channel blockers, such as verapamil and diltiazem, may increase the risk of hypercalcemia when used with Cholecalciferol.
• Cholestyramine and colestipol can bind to vitamin D and reduce its absorption.
• Vitamin D may enhance the absorption of aluminum from antacids, potentially leading to aluminum toxicity.
• Caution is advised with digoxin, as vitamin D can increase serum calcium levels, which may affect the effectiveness and toxicity of digoxin.

Following are the food interactions for Cholecalciferol 200,000iu Solution:

• Avoid high-fat meals as they may reduce the absorption of Vitamin D, leading to decreased effectiveness.
• Consuming foods rich in Vitamin D, like fatty fish, egg yolks, and fortified dairy products, alongside the supplement can enhance Vitamin D levels in the body.
• Ensure adequate calcium intake through diet or supplements as Vitamin D aids in calcium absorption.
• Limit caffeine intake as excessive caffeine may reduce Vitamin D absorption and impact its effectiveness.
• Avoid excessive alcohol consumption as it can interfere with Vitamin D metabolism and reduce its effectiveness.
• Consider taking the supplement with a meal containing healthy fats to enhance its absorption.
• Certain medications, such as corticosteroids and anti-seizure drugs, can interfere with Vitamin D metabolism, so consult your healthcare provider for guidance.
• Always follow the dosage instructions provided by your healthcare professional for optimal results.

Cholecalciferol 200,000iu Solution should be stored in a secure and controlled environment, preferably in a cool and dry place, ensuring it is kept away from direct sunlight, heat, and moisture. It is crucial to store the solution in its original container, tightly sealed, to maintain its integrity and prevent contamination. Always check the expiration date, and if the solution is past its expiry or no longer needed, proper disposal is essential. Do not dispose of it in household trash or pour it down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the solution out of children's reach to prevent accidental consumption, as it can be harmful if ingested.

Following are the quick tips for Cholecalciferol 200,000iu Solution:

• Consult a doctor for personalized dosage instructions based on your vitamin D levels.
• Take the solution as directed by your healthcare provider; do not self-medicate.
• Administer the solution directly into the mouth using the provided dropper for accurate dosing.
• Ensure the solution is administered into the mouth and not on the skin to prevent wastage.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Keep the medication out of reach of children to prevent accidental ingestion.
• Inform your doctor if you have any kidney or liver diseases before taking this medication.