Dacriva (60mg) 28 Tablets

Dacriva (60mg) 28 Tablets

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  • Manufacturer CCL Pharmaceuticals
  • Generic Name

    Daclatasvir 60mg

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4.9/ 5
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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Daclatasvir 60mg Tablet is an antiviral medication that works by inhibiting the non-structural protein 5A (NS5A) of the hepatitis C virus (HCV). NS5A is crucial for the replication and assembly of the virus. By binding to this protein, Daclatasvir prevents the replication of the HCV and its ability to produce new viral particles. This helps in reducing the viral load in the body, leading to improved outcomes in patients with chronic hepatitis C infection. Daclatasvir is often used in combination with other antiviral agents, such as sofosbuvir, to provide a more effective treatment regimen and increase the likelihood of achieving a sustained virologic response (SVR).

  • Ingredients

    Daclatasvir 60mg

  • Drug Class

    direct-acting antivirals (DAAs), specifically categorized as an NS5A inhibitor.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Daclatasvir 60mg Tablet:

    • Treatment of chronic hepatitis C virus (HCV) infection in adults.
    • Used in combination with other antiviral medications (e.g., sofosbuvir) for the treatment of HCV genotypes 1, 3, 4, 5, and 6.
    • Management of hepatitis C in patients with cirrhosis or prior treatment failure, as part of a combination regimen.
    • Treatment of HCV infection in individuals co-infected with HIV, when used with appropriate antiretroviral therapy.
    • Used to reduce the risk of hepatitis C relapse and to achieve sustained virologic response (SVR) in appropriate patients.
  • Dosage

    Following are the doses of Daclatasvir 60mg Tablet:

    • The usual dose for the treatment of chronic hepatitis C in adults is one 60mg tablet taken once daily, in combination with other antiviral medications, as prescribed by your healthcare provider.
    • The dose may vary depending on the specific combination therapy and the patient's liver condition. Always follow the exact dosing schedule provided by your healthcare provider to ensure optimal treatment.
    • In patients with moderate to severe liver impairment, the dose may need to be adjusted, and close monitoring is recommended.
    • Do not adjust the dose or stop taking the medication without consulting your healthcare provider.
  • In case of Overdose

    In case of an overdose of Daclatasvir 60mg Tablet, immediate medical attention should be sought. An overdose may increase the risk of side effects such as fatigue, headache, nausea, or liver enzyme abnormalities. Do not attempt to self-treat the overdose. If you suspect an overdose, contact your healthcare provider or a poison control center immediately. Do not take additional doses to make up for the missed one, and follow all instructions provided by your healthcare provider.

  • Missed Dose

    If you miss a dose of Daclatasvir 60mg Tablet, take it as soon as you remember, unless it is nearly time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for the missed dose, as this could increase the risk of side effects.

  • How To Use

    To use Daclatasvir 60mg Tablet, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken once daily, with or without food. Swallow the tablet whole with a glass of water. Do not chew, crush, or break the tablet. It is important to take the medication at the same time each day to help you remember and maintain consistent levels in your body.

  • When Not to Use

    Following are the situations when Daclatasvir 60mg Tablet should not be used:

    • Should not be used in individuals with a known allergy to Daclatasvir or any of its components.
    • Contraindicated in patients with severe liver impairment (Child-Pugh Class C).
    • Should not be used in combination with certain antiviral medications (e.g., rifampin, St. John's Wort) as they may reduce its effectiveness.
    • Contraindicated in pregnant women when used with certain combination treatments, as it may harm the fetus.
    • Should not be used in patients with active HIV unless prescribed appropriate antiretroviral therapy alongside Daclatasvir.
  • Side Effects

    The side effects of Daclatasvir 60mg Tablet may include:

    • Fatigue
    • Headache
    • Nausea
    • Diarrhea
    • Insomnia
    • Rash
    • Decreased appetite
    • Muscle pain
    • Liver enzyme elevations
    • Anemia
  • Precautions & Warnings

    Following are the situations when Daclatasvir 60mg Tablet should not be used:

    • Should not be used in individuals with a known allergy to Daclatasvir or any of its ingredients.
    • Contraindicated in patients with severe liver impairment (Child-Pugh Class C).
    • Should not be used during pregnancy, unless the potential benefits outweigh the risks, as it can harm the fetus when used in combination with certain other antiviral drugs.
    • Contraindicated in patients who are co-infected with HIV and have not been prescribed appropriate antiretroviral therapy, as Daclatasvir should only be used with specific medications for hepatitis C.
  • Drug Interactions

    Following are the drug interactions for Daclatasvir 60mg Tablet:

    • Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) can increase the concentration of Daclatasvir in the blood, raising the risk of side effects.
    • Concomitant use with rifampin (a strong CYP3A4 inducer) may decrease the effectiveness of Daclatasvir by lowering its levels in the blood.
    • Caution is advised when combining Daclatasvir with other antiviral medications, particularly those used to treat hepatitis C (e.g., sofosbuvir, ledipasvir), as drug-drug interactions may alter the efficacy or increase side effects.
    • Anticonvulsants (e.g., phenytoin, carbamazepine) and herbal supplements (e.g., St. John's Wort) that induce CYP enzymes may reduce the effectiveness of Daclatasvir.
    • HIV medications (e.g., efavirenz) should be used cautiously with Daclatasvir, as they may interfere with its effectiveness or increase the risk of side effects.
    • P-glycoprotein inducers (e.g., rifampin) may reduce the concentration of Daclatasvir, affecting its antiviral activity.
  • Food Interactions

    Following are the food interactions for Daclatasvir 60mg Tablet:

    • Daclatasvir can be taken with or without food, so there are no specific dietary restrictions.
    • Grapefruit or grapefruit juice should be avoided while taking Daclatasvir, as it may interfere with the metabolism of the drug and increase the risk of side effects.
    • Alcohol should be consumed with caution, as excessive drinking can strain the liver and potentially interfere with the effectiveness of the treatment.
    • There are no known interactions with common foods, but maintaining a balanced diet to support overall liver health is recommended during treatment.
  • Storage/Disposal

    Daclatasvir 60mg Tablet should be stored at room temperature, away from moisture and heat. Keep the medication in its original packaging to protect it from light and humidity. Store it in a dry place, and ensure it is out of reach of children. Do not store it in the bathroom or near the kitchen sink, as these areas may have excessive moisture. If the medication is expired or no longer needed, it should not be flushed down the toilet or thrown in the trash. Instead, follow local disposal guidelines or return the medication to a pharmacy that offers a medication take-back program. Always check with your healthcare provider or pharmacist if you're unsure about how to dispose of the medication safely.

  • Quick Tips, if any

    Following are the quick tips for Daclatasvir 60mg Tablet:

    • Take Daclatasvir exactly as prescribed by your healthcare provider, usually with other antiviral medications, to ensure effective treatment of hepatitis C.
    • Take the tablet at the same time each day to help remember.
    • You can take Daclatasvir with or without food, but it's important to follow your doctor's instructions.
    • Do not skip doses or stop the medication without consulting your healthcare provider, as this can affect the treatment's effectiveness.
    • Drink plenty of fluids and maintain a healthy diet during treatment to support liver function.
    • Regularly attend follow-up appointments with your healthcare provider to monitor your response to treatment and any potential side effects.
    • If you experience any unusual symptoms like severe fatigue, yellowing of the skin/eyes, or dark urine, contact your healthcare provider immediately.

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