Daivonex (50mcg/g) 30g Ointment

Calcipotriol, the active ingredient in Calcipotriol Ointment, is a synthetic derivative of vitamin D3. Its mechanism of action primarily involves regulating the proliferation and differentiation of keratinocytes in the epidermis. Calcipotriol binds to the vitamin D receptors (VDR) present in the skin cells, which then forms a complex that interacts with specific DNA sequences, modulating gene expression. This leads to the normalization of keratinocyte growth and differentiation, reducing the excessive skin cell turnover seen in conditions like psoriasis. By promoting the maturation of immature keratinocytes, calcipotriol helps restore the skin's natural barrier function and reduces inflammation. It also has anti-inflammatory properties, downregulating the production of pro-inflammatory cytokines and inhibiting the activation of immune cells, ultimately contributing to the resolution of psoriatic lesions.

Calcipotriol

vitamin D analogue.

Ointment

The following are the uses of Calcipotriol Ointment:

• Used for treating plaque psoriasis, effectively reducing skin inflammation and scaling.
• Used to slow down the rapid growth of skin cells in affected areas.
• Used for topical application on the skin, providing relief from itching and discomfort.
• Used to improve skin texture and appearance by reducing redness and thickening.
• Used for managing chronic plaque psoriasis, offering long-term control.
• Used as an alternative to corticosteroids, with fewer side effects on the skin.
• Used in combination with other treatments for optimal psoriasis management.

In the case of an overdose of Calcipotriol Ointment, it is important to note that excessive use can lead to an increase in the severity of potential side effects. The most common symptoms of an overdose may include skin irritation, redness, and itching at the application site. If ingested, it could cause nausea, vomiting, and an upset stomach. In such instances, it is advisable to seek medical advice and consult a healthcare professional for appropriate guidance and treatment.

In the case of a missed dose of Calcipotriol Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, simply skip the missed application and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for guidance on how to adjust your treatment plan. It is essential to maintain consistency in applying the ointment for optimal results.

To apply Calcipotriol Ointment, wash your hands and gently clean the affected skin area, then apply a thin layer of the ointment to the skin as directed by your healthcare provider, typically once or twice a day, and gently rub it in until it is evenly distributed.

Following are the conditions/situations when Calcipotriol Ointment should not be used:

• Should not be applied to the face or skin folds.
• Contraindicated in individuals who are allergic to Calcipotriol or any vitamin D derivatives.
• Not suitable for individuals with severely impaired kidney function.
• Avoid using on skin conditions such as eczema, psoriasis in the genital area, or severe forms of psoriasis.
• Do not use on skin that is sunburned, infected, or has open wounds.
• Should not be used on children under 12 years of age.
• Contraindicated in individuals with a history of calcium disorders or conditions that increase calcium levels in the body.
• Avoid using on skin that is highly sensitive or has a tendency to react easily.
• Not recommended for individuals with a history of allergic reactions to topical medications.

The side effects of Calcipotriol Ointment may include:

• Skin irritation or redness at the application site
• Itching or burning sensation
• Dry skin or peeling
• Rash or eczema
• Skin thinning or discolouration
• Mild headache
• Allergic reactions (such as hives, difficulty breathing)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Calcipotriol Ointment:

• Avoid contact with eyes and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Calcipotriol may cause skin irritation or burning sensation; if this occurs, discontinue use and consult a healthcare professional.
• Do not apply on broken or infected skin.
• This medication is for external use only and should not be ingested.
• Keep out of reach of children. If accidentally ingested, seek immediate medical attention.
• Do not use on skin conditions that are not prescribed by a doctor.
• Inform your doctor if you have any kidney or liver problems before using this medication.

Following are the drug interactions for Calcipotriol Ointment:

• Calcipotriol may interact with topical corticosteroids, which are often used in combination therapy, increasing the risk of skin irritation and adverse effects.
• Concomitant use with other vitamin D analogues or retinoids may lead to enhanced skin reactions and potential toxicity.
• It can increase the sensitivity of the skin to sunlight, so caution is advised when using with other photosensitizing medications.
• Avoid using other topical medications at the same treatment site without medical advice to prevent potential interactions.
• Calcipotriol may have reduced effectiveness when used with topical emollients or protective creams.
• Some drugs affecting the metabolism of vitamin D, such as phenobarbital or phenytoin, might decrease the efficacy of Calcipotriol.
• Caution is warranted when combining with systemic medications that affect calcium metabolism, as it may lead to altered calcium levels.

Following are the food interactions for Calcipotriol Ointment:

• Calcipotriol can be affected by high-fat diets, as increased fat intake may reduce the drug's effectiveness.
• Avoid consuming excessive amounts of calcium-rich foods or supplements, as this can lead to elevated calcium levels in the blood.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the absorption of Calcipotriol.
• Alcohol may not directly interact with Calcipotriol, but excessive alcohol consumption can negatively impact skin health and healing.
• Avoid Vitamin D-fortified foods or supplements, as Calcipotriol is a synthetic vitamin D derivative, and excessive Vitamin D intake can cause toxicity.
• Certain leafy green vegetables high in Vitamin K, like spinach and kale, should be consumed in moderation to prevent potential interactions with Calcipotriol's vitamin D-like effects.
• Dairy products, being rich in calcium, should be consumed in moderation to maintain balanced calcium levels in the body.
• Always follow your healthcare provider's advice on dietary restrictions or modifications during Calcipotriol Ointment treatment.

Calcipotriol Ointment should be stored with caution, ensuring it is kept in a cool, dry place, ideally at room temperature, away from direct sunlight and heat sources. Maintaining the original packaging and keeping the tube tightly sealed is crucial to prevent contamination. Always check the expiration date before use, and never use the ointment if it has passed its expiry. Disposal of Calcipotriol Ointment requires responsible action; do not flush it down the toilet or pour it into a drain. Instead, consult your pharmacist or local waste management guidelines for safe and environmentally friendly disposal methods. Keep the medication away from children to prevent accidental exposure or ingestion. Proper storage and disposal practices are essential to ensure the safety and effectiveness of the ointment.

Following are the quick tips for Calcipotriol Ointment:

• Clean and dry the affected skin area before applying the ointment.
• Use the provided applicator or a clean fingertip to apply a thin layer to the skin.
• Gently rub the ointment into the skin until it is absorbed.
• Avoid applying the ointment to healthy skin or areas not affected by psoriasis.
• Wash your hands after application to prevent accidental contact with sensitive areas.
• Do not cover the treated skin with bandages or tight clothing.
• Regularly monitor your skin for any improvements or side effects during treatment.