Dalacin C (300mg/2ml) 1 Ampoule Injection

Dalacin C (300mg/2ml) 1 Ampoule Injection

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  • Manufacturer PFIZER LABORATORIES LTD
  • Generic Name

    Clindamycin 300mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Clindamycin 300mg injection primarily exerts its antibacterial action by inhibiting bacterial protein synthesis. It achieves this by binding to the 50S subunit of the bacterial ribosome, thereby preventing the formation of functional peptide bonds during protein synthesis. This binding interferes with the translocation step in protein synthesis, leading to the suppression of peptide chain elongation and subsequent inhibition of bacterial growth. Clindamycin is particularly effective against Gram-positive bacteria and certain anaerobic bacteria, as it can penetrate into these cells and reach the site of action. The mechanism of action of clindamycin is distinct from that of other antibiotic classes, making it a valuable option for treating infections caused by susceptible organisms.

  • Ingredients

    Clindamycin 300mg

  • Drug Class

    Lincosamide antibiotic

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Clindamycin 300mg injection:

    • Used for treating serious bacterial infections that require rapid onset of action, especially in critical cases.
    • Used for targeting infections caused by susceptible anaerobic bacteria and some protozoa.
    • Used for skin and soft tissue infections, including cellulitis and abscesses.
    • Used for respiratory tract infections such as pneumonia and empyema.
    • Used for bone and joint infections, including osteomyelitis.
    • Used for intra-abdominal infections like peritonitis and abscesses.
    • Used for gynecological infections, particularly in cases of endometritis and pelvic inflammatory disease.
    • Used for treating severe infections in patients allergic to penicillin or when other antibiotics are not suitable.
  • In case of Overdose

    In the case of an overdose of Clindamycin 300mg injection, it is crucial to act promptly. Seek immediate medical attention, as an overdose may lead to severe gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Additionally, an overdose can cause allergic reactions, including skin rashes and itching. Prompt medical intervention is essential to manage these symptoms and prevent potential complications. Timely treatment can ensure a better outcome and minimize the risks associated with an overdose.

  • Missed Dose

    In the case of a missed dose of Clindamycin 300mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting the remaining doses to ensure the full course of treatment is completed effectively.

  • How To Use

    To administer Clindamycin 300mg injection, clean the injection site with an alcohol swab, insert the needle into the vial, withdraw the prescribed dose, inject it into the muscle, and discard the used needle and syringe safely.

  • When Not to Use

    Following are the conditions/situations when Clindamycin 300mg injection should not be administered:

    • Allergic reactions Should not be used if the patient has a known allergy to Clindamycin, lincomycin, or any other ingredients in the injection.
    • Infections Not indicated for the treatment of viral infections such as the common cold or flu.
    • Liver or kidney disease Contraindicated in patients with severe liver or kidney impairment.
    • Pseudomembranous colitis Should not be used in patients with a history of this condition, a severe form of diarrhea.
    • Severe heart conditions Not recommended for patients with certain heart diseases or those who have experienced a recent heart attack.
    • Blood disorders Clindamycin should be avoided in patients with a history of blood disorders, particularly low white blood cell counts.
    • Electrolyte imbalances Not suitable for patients with severe electrolyte disturbances, especially low potassium levels.
    • Pregnancy and breastfeeding Clindamycin is usually avoided during pregnancy and breastfeeding unless the potential benefits outweigh the risks.
    • Underlying bowel disease Should not be used in patients with a history of inflammatory bowel disease.
    • Severe systemic diseases Contraindicated in patients with severe systemic diseases, such as systemic lupus erythematosus (SLE).
    • Severe skin reactions Should not be used in patients who have experienced severe skin reactions with previous use of Clindamycin or similar antibiotics.
    • Allergic reactions to other antibiotics Not recommended for patients with a history of severe allergic reactions to other antibiotics, especially lincomycin.
  • Side Effects

    The side effects of Clindamycin 300mg injection may include:

    • Nausea and vomiting
    • Diarrhea or loose stools
    • Abdominal pain or cramps
    • Allergic reactions (skin rash, itching, hives)
    • Joint and muscle pain
    • Inflammation of the veins (phlebitis) at the injection site
    • Changes in liver function
    • Increased risk of developing antibiotic-resistant bacteria
  • Precautions & Warnings

    Following are the precautions and warnings:

    • Clindamycin 300mg injection should not be administered to individuals with a known hypersensitivity or severe allergic reaction to clindamycin, lincomycin, or any other ingredients in the formulation.
    • This injection is intended for intravenous use only and should be administered by trained medical professionals to prevent medication errors.
    • Caution is advised in patients with a history of gastrointestinal diseases, particularly those with a predisposition to inflammatory bowel disease, as Clindamycin can cause severe diarrhea and intestinal inflammation.
    • It should be used with caution in individuals with kidney or liver impairment, as dosage adjustments may be necessary to prevent accumulation and potential toxicity.
    • Clindamycin may lead to the development of antibiotic-resistant bacteria with prolonged use, so it should only be used for the duration prescribed by the doctor.
    • Patients should complete the full course of treatment, even if they feel better, to ensure the infection is completely eradicated and to prevent antibiotic resistance.
    • Pregnant and breastfeeding women should consult their doctor before using Clindamycin, as it may pose risks to the fetus or infant.
    • Elderly patients may be more susceptible to the side effects of Clindamycin, and their response to the medication should be closely monitored.
  • Drug Interactions

    Following are the drug interactions for Clindamycin 300mg injection:

    • Erythromycin and other macrolide antibiotics may compete for the same binding sites, potentially reducing the effectiveness of Clindamycin.
    • Concomitant use with neuromuscular blocking agents may enhance the neuromuscular blocking effect, requiring close monitoring.
    • Clindamycin may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
    • The risk of cardiac toxicity may increase when used with other drugs known to prolong the QT interval, such as amiodarone.
    • It may interact with warfarin, requiring close monitoring of coagulation parameters due to potential changes in INR.
    • Drugs that induce or inhibit CYP3A4 enzymes can affect Clindamycin metabolism, potentially altering its efficacy.
    • Caution is advised when using with histamine H2-receptor antagonists, as it may reduce Clindamycin absorption.
  • Food Interactions

    Following are the food interactions for Clindamycin 300mg injection:

    • Avoid consuming alcohol during the treatment as it may increase the risk of side effects, particularly gastrointestinal issues.
    • Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Clindamycin, potentially altering its effectiveness.
    • Dairy products like milk, cheese, and yogurt can reduce the absorption of Clindamycin, so it is best to separate them by at least 2 hours before or after medication.
    • High-fiber foods such as whole grains, legumes, and certain vegetables may decrease the absorption of Clindamycin. Consume them in moderation and monitor for any changes in treatment effectiveness.
    • Avoid consuming large amounts of calcium-rich foods like dairy, calcium-fortified juices, and supplements simultaneously with Clindamycin, as they can form insoluble complexes, reducing the drug's bioavailability.
    • Certain foods like spices, hot beverages, and acidic foods may aggravate gastrointestinal side effects like nausea and stomach upset during treatment.
    • Ensure adequate hydration and a balanced diet to support overall health and recovery during the course of treatment.
    • No significant interactions with specific foods have been reported for Clindamycin, but it is always advisable to consult your healthcare provider for personalized advice regarding dietary considerations.
  • Storage/Disposal

    Clindamycin 300mg injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. It is crucial to maintain the integrity of the medication by storing it in its original packaging, ensuring the container is tightly sealed. Avoid exposing the injection to extreme temperatures, such as those found in bathrooms, near stoves, or radiators, as this can compromise its effectiveness. Always check the expiration date, and if the medication is past its expiry, do not flush or pour it down the drain. Instead, consult a pharmacist or healthcare professional for safe disposal instructions. Keep the injection out of children's reach to prevent accidental exposure or ingestion. Proper storage and disposal practices are essential to maintain the medication's efficacy and ensure the safety of those around you.

  • Quick Tips, if any

    Following are the quick tips for Clindamycin 300mg injection:

    • Administer the injection under medical supervision for proper dosage and administration.
    • Ensure the injection is prepared and stored as per the instructions on the label.
    • Verify the patient's identity and medication details before injecting.
    • Use a sterile needle and syringe for the injection to prevent infection.
    • Inject the medication slowly, as directed, to minimize discomfort.
    • Do not reuse or share needles to prevent the spread of infections.
    • Report any severe side effects or allergic reactions immediately.

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