Dalacin-C (600mg) 4ml, 1 Ampoule Injection

Clindamycin, a lincosamide antibiotic, exerts its bactericidal effect primarily by binding to the 50S subunit of bacterial ribosomes, thereby inhibiting protein synthesis. This binding occurs preferentially on the bacterial 23S rRNA, which is structurally different from the corresponding region in human ribosomes, making it selective for bacterial ribosomes. Clindamycin prevents the transpeptidation or translocation steps of protein synthesis, leading to the inhibition of peptide chain elongation and subsequent bacterial growth. By disrupting the bacterial protein synthesis machinery, Clindamycin effectively kills susceptible bacteria, including gram-positive cocci, gram-negative cocci, and certain anaerobic bacteria.

Clindamycin

Lincosamide antibiotic

Injection

The following are the uses of Clindamycin injection:

• Used for treating serious bacterial infections like pneumonia, bone and joint infections, and severe skin infections.
• Used for infections caused by anaerobic bacteria and certain types of parasites.
• Used in cases where the infection is severe or when oral medication cannot be administered.
• Used for infections that require rapid onset of action and high tissue penetration.
• Used for treating infections caused by susceptible strains of streptococci, pneumococci, and staphylococci.
• Used as an alternative for patients allergic to penicillin or when other antibiotics are not suitable.
• Used for preventing infections in surgical procedures, particularly for abdominal and gynecological surgeries.
• Used to treat deep-seated or life-threatening infections when other antibiotics have failed.

In the case of an overdose of Clindamycin injection, it is crucial to seek medical assistance promptly. Symptoms of an overdose may include severe diarrhea, abdominal pain, and potentially dangerous changes in blood pressure. Medical professionals should be informed about the dosage and timing of the injection to determine the best course of action. Quick response and appropriate medical care are essential to manage any adverse effects and ensure the patient's well-being.

In the case of a missed dose of Clindamycin injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may need to adjust your dosing schedule to ensure the treatment's effectiveness. It is crucial to follow the prescribed treatment plan for the best results.

To administer the Clindamycin injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire medication is delivered, then gently remove the needle and apply light pressure with a sterile bandage if needed.

Following are the conditions/situations when Clindamycin injection should not be administered:

• Allergic reactions Should not be used if the patient has a known allergy to Clindamycin, lincomycin, or any other ingredients in the injection.
• Severe liver impairment Not recommended for patients with severe liver problems as it may worsen their condition.
• Pseudomembranous colitis Contraindicated in patients with a history of or active pseudomembranous colitis, a severe form of diarrhea.
• Antibiotic-associated colitis Should not be used if the patient has a history of antibiotic-associated colitis caused by any antibiotic.
• Esophageal or gastrointestinal conditions Not suitable for patients with pre-existing esophageal or gastrointestinal conditions, such as esophageal ulcers or severe gastrointestinal diseases.
• Neonates Clindamycin injection should not be used in neonates, especially those with hyperbilirubinemia or premature infants.
• Prolonged use Prolonged or unnecessary use of the injection should be avoided to prevent the development of antibiotic resistance.

The side effects of Clindamycin injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rashes or itching
• Pain or swelling at the injection site
• Joint pain
• Fever
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Changes in bowel habits, including pseudomembranous colitis

Following are the precautions and warnings for Clindamycin injection:

• Clindamycin should not be administered to individuals with a history of hypersensitivity or severe allergic reactions to clindamycin, lincomycin, or any other ingredients in the formulation.
• It is crucial to exercise caution in patients with a history of gastrointestinal diseases, particularly those with pre-existing inflammation or ulceration, as Clindamycin may exacerbate these conditions.
• Patients with a history of kidney or liver impairment may require dosage adjustments, as Clindamycin is primarily metabolized and excreted by these organs.
• This medication should be used with caution in individuals with asthma or a history of allergic reactions, as it may trigger or worsen respiratory symptoms.
• Prolonged use of Clindamycin may lead to the overgrowth of non-susceptible bacteria or fungi, which could result in superinfections. Regular monitoring is essential.
• Patients should be advised to complete the full course of treatment, even if symptoms improve before completion, to ensure the infection is fully eradicated.
• Clindamycin should be used with caution in elderly patients, as they may be more susceptible to the side effects associated with this medication.

Following are the drug interactions for Clindamycin injection:

• Concomitant use with neuromuscular blocking agents may enhance the effects of neuromuscular blockade, leading to prolonged muscle paralysis.
• Erythromycin and other macrolide antibiotics may antagonize the effects of clindamycin, reducing its effectiveness in treating infections.
• Cyclosporine may increase the risk of nephrotoxicity when used with clindamycin, requiring careful monitoring of kidney function.
• Antacids containing calcium, magnesium, or aluminum may reduce the absorption of clindamycin when taken orally, though this interaction is less relevant for the injectable form.
• Warfarin may increase the risk of bleeding when used with clindamycin, requiring close monitoring of INR levels.
• Benzodiazepines may have an enhanced sedative effect when combined with clindamycin, increasing the risk of drowsiness or respiratory depression.
• Diuretics may increase the risk of electrolyte imbalances, such as hypokalemia, when combined with clindamycin.

Following are the food interactions to be aware of when taking Clindamycin injections:

• Avoid consuming alcohol during the treatment period as it may cause increased side effects like nausea, stomach upset, and potential liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Clindamycin, leading to higher drug levels in the body and increased risk of adverse effects.
• Dairy products like milk, cheese, and yogurt may decrease the absorption of Clindamycin, so it is best to take the medication at least one hour before or two hours after consuming these foods.
• Foods high in fiber may also reduce the absorption of Clindamycin, so consider adjusting your diet to minimize fiber intake during treatment.
• Avoid consuming large amounts of cruciferous vegetables like broccoli, cauliflower, and Brussels sprouts, as they may affect the effectiveness of Clindamycin.
• Certain protein-rich foods like red meat and eggs may interact with Clindamycin, potentially reducing its effectiveness, so ensure you maintain a balanced diet.
• Always ensure you are well-hydrated when receiving Clindamycin injections to support kidney function and overall health.
• Consult your healthcare provider for personalized advice on diet and nutrition during Clindamycin treatment.

Clindamycin injection storage and disposal should be done with careful consideration to ensure safety and environmental responsibility. Store the medication at room temperature, away from direct sunlight and moisture. Keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid extreme temperatures by not storing it in the bathroom or near heat sources. Regularly check the expiration date, and if the injection is expired or no longer needed, do not dispose of it by flushing or pouring it down the drain. Contact your pharmacist or healthcare provider for guidance on proper disposal methods to ensure it is done safely and in accordance with local regulations. Keep the medication out of children's reach to prevent accidental exposure or ingestion. Proper storage and disposal practices are crucial to minimize risks and protect both individuals and the environment.

Following are the quick tips for Clindamycin injection:

• Ensure the injection is administered by a healthcare professional for safety and proper dosage.
• Inform your doctor about any allergies or medical conditions before receiving the injection.
• During the treatment period, stay well-hydrated to reduce the risk of side effects.
• Avoid alcohol consumption as it may intensify the medication's side effects.
• Complete the full course of treatment, even if you feel better, to ensure effectiveness.
• Do not stop the medication without consulting your doctor to prevent bacterial resistance.
• Store the medication as directed and protect it from direct sunlight and moisture.