DANTRIUM IMP 25MG CAP (DANTROLENE NA)

Dantrolene sodium, the active ingredient in the 25mg capsule, acts as a muscle relaxant primarily by interfering with the release of calcium ions from the sarcoplasmic reticulum within muscle cells. This interference occurs through its direct binding to the ryanodine receptor, a calcium release channel. By inhibiting the release of calcium ions, dantrolene reduces muscle fiber contractions, leading to overall muscle relaxation. This mechanism is particularly effective in treating conditions associated with excessive muscle contractions, as it helps alleviate muscle spasms and associated symptoms.

DANTROLENE Na 25MG

Skeletal muscle relaxant.

Capsule

The following are the uses of DANTROLENE Na 25MG Capsule:

• Used for treating malignant hyperthermia, a rare but life-threatening condition triggered by exposure to certain anesthetics or muscle relaxants.
• Used for managing and preventing muscle spasms and rigidity associated with neurological conditions such as stroke, multiple sclerosis, and cerebral palsy.
• Used for treating and managing muscle stiffness and spasms in patients with spinal cord injuries, helping to improve mobility and reduce pain.
• Used for treating and preventing muscle hyperactivity and spasms in various muscle-related disorders, including myotonia and muscle cramps.
• Used for managing heat stroke and exertional rhabdomyolysis, conditions where muscle breakdown and elevated body temperature can be life-threatening.
• Used for treating and preventing muscle spasms and stiffness in patients undergoing physical rehabilitation, aiding in recovery and improving functional outcomes.
• Used for managing and preventing muscle spasms in patients with dystonia, a movement disorder causing involuntary muscle contractions.

In the case of an overdose of Dantrolene Na 25MG Capsules, the severity of symptoms can vary. Common signs may include increased muscle weakness, difficulty breathing, and abnormal heart rhythms. It is important to recognize that an overdose can lead to life-threatening complications, particularly in individuals with pre-existing medical conditions. Prompt medical intervention is essential to manage symptoms and prevent potential long-term health consequences.

In the case of a missed dose of DANTROLENE Na 25MG Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your medication regimen. It is crucial to maintain a consistent medication routine for optimal effectiveness.

To take DANTROLENE Na 25MG Capsule, swallow the capsule whole with a full glass of water, preferably during or after a meal, exactly as prescribed by your healthcare professional, ensuring you do not exceed the recommended dosage.

Following are the conditions/situations when DANTROLENE Na 25MG Capsule should not be used:

• Must not be used in patients with known hypersensitivity or allergy to Dantrolene or any of its excipients.
• Contraindicated in patients with liver disease or impaired liver function.
• Not recommended for individuals with active muscle-related injuries or conditions, such as severe muscle trauma or recent muscle surgery.
• Should not be used in patients with a history of liver problems or jaundice after previous use of Dantrolene.
• Contraindicated during pregnancy as it may cause harm to the unborn baby.
• Not suitable for individuals with severe heart or lung disease, as it may worsen respiratory function.
• Should not be used in patients with known porphyria, a disorder affecting the production of heme in the body.

The side effects of DANTROLENE Na 25MG Capsule may include:

• Muscle weakness or fatigue
• Dizziness or lightheadedness
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Increased thirst and urination
• Skin rashes or itching
• Difficulty breathing or swallowing

Following are the precautions and warnings for Dantrolene Na 25MG Capsule:

• This medication is intended for the treatment of specific muscle-related conditions and should only be used as prescribed by a healthcare professional.
• Patients with known allergies to dantrolene or any other ingredients in the capsule should not take this medication.
• Dantrolene may cause liver damage; regular monitoring of liver function is necessary during treatment. Discontinue use if signs of liver injury occur.
• Caution is advised for patients with pre-existing liver disease, as this medication can further affect liver function.
• Elderly patients may be more susceptible to the side effects of this medication, and dosage adjustments might be required.
• Dantrolene may cause muscle weakness; patients should avoid activities that require strength or coordination until they know how this medication affects them.
• Patients should not stop taking this medication abruptly without medical advice, as it may lead to withdrawal symptoms.
• Dantrolene may interact with other medications; inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Dantrolene Sodium 25MG Capsule:

• Dantrolene may interact with other muscle relaxants, leading to enhanced muscle weakness and potential respiratory depression.
• Antiepileptic medications like phenytoin can reduce the effectiveness of dantrolene, requiring close monitoring of therapeutic response.
• Caution is advised when combining Dantrolene with drugs that affect the heart, such as beta-blockers, as it may cause additional cardiac depression.
• The effectiveness of oral contraceptives may be reduced by dantrolene, requiring alternative contraceptive methods.
• The risk of liver damage may increase when Dantrolene is used with other hepatotoxic medications.
• Drugs that increase stomach acidity, such as proton pump inhibitors, may reduce Dantrolene's absorption, potentially requiring dosage adjustments.
• Dantrolene can interact with medications metabolized by the liver, such as certain antibiotics, potentially affecting the efficacy of both drugs.

Following are the food interactions for Dantrolene Na 25MG Capsule:

• Avoid consuming grapefruit and grapefruit juice, as these can interfere with the metabolism of Dantrolene, potentially leading to increased drug levels in the body and heightened side effects.
• Alcohol consumption should be limited or avoided as it can enhance the sedative effects of Dantrolene, increasing the risk of dizziness and drowsiness.
• High-fat meals can slow down the absorption of Dantrolene, potentially reducing its effectiveness. It is best to take the medication on an empty stomach or with a light meal.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may increase muscle spasticity and counteract the effects of Dantrolene, and should be consumed in moderation.
• Avoid eating large amounts of dairy products as they may lead to increased calcium levels, which can interact with Dantrolene's muscle-relaxing effects.
• Certain herbal supplements like St. John's Wort can impact the metabolism of Dantrolene and should be used with caution.
• Consuming foods rich in vitamin D and calcium supplements should be monitored, as Dantrolene may affect calcium metabolism.
• There is no specific food restriction, but maintaining a balanced diet is essential for overall health when taking Dantrolene.

Dantrolene Na 25MG Capsules should be stored in a cool, dry, and dark environment, preferably in a medicine cabinet or a designated storage area. It is crucial to keep the capsules in their original packaging or a tightly sealed container to maintain their integrity and protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas may have high humidity or temperature fluctuations. Always check the expiration date, and never use the medication beyond this date. When it comes to disposal, do not flush the capsules down the toilet or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for environmentally friendly disposal options to prevent any potential harm to the environment. Keep the capsules out of children's reach to ensure their safety.

Following are the quick tips for DANTROLENE Na 25MG Capsule:

• Swallow the capsule whole; do not crush, chew, or open it.
• Take the capsule with a full glass of water to ensure easy swallowing.
• Administer the capsule as directed by your healthcare professional.
• Avoid missing doses; take it at the same time daily to maintain consistent levels.
• If you experience difficulty swallowing, discuss alternative forms with your doctor.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Inform your doctor if you have any muscle-related conditions before taking this medication.