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Deliver to
Lahore
Daonil M (5/500mg) 30 Tablets
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- Manufacturer AVENTIS PHARMACEUTICALS (PVT.) LTD.
- Generic Name Metformin, Glibenclamide
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Product Information
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Description
It contains; Glibenclamide and Metformin as its active components. Glibenclamide performs its effect by stimulating insulin release from the pancreatic beta cells; reducing glucose output from the liver; increasing insulin sensitivity at peripheral target sites. Glibenclamide is a sulfonylurea oral hypoglycemic drug. This medicine works by increasing secretion of insulin from the pancreas, it interacts with sulfonylurea receptors on beta cells or interferes with ATP-sensitive potassium channels on pancreatic beta cells, which increases secretion of insulin. This medicine also increases sensitivity of existing insulin receptors. Metformin (N, N-dimethylbiguanide) belongs to the biguanide class of antidiabetic drugs (containing two linked guanidine rings). This drug has a major clinical advantage that it does not induce hypoglycemia or weight gain with remarkable cardiovascular safety. Metformin is also used for the treatment of polycystic ovary disease, diabetic nephropathy, and gestational diabetes. Metformin acts via both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms; by inhibiting mitochondrial respiration and inhibiting mitochondrial glycerophosphate dehydrogenase, and a mechanism involving the lysosome. Metformin acts directly or indirectly on the liver in order to reduce glucose production, and acts on the gut to increase glucose utilization. At the molecular level, metformin acts to inhibit the mitochondrial respiratory chain in the liver, which results in activation of AMPK, enhances insulin sensitivity (via effects on fat metabolism) and lowers cAMP, and reduces the expression of gluconeogenic enzymes. Metformin shows AMPK-independent effects on the liver that results in inhibition of fructose-1,6-bisphosphatase by AMP. -
Ingredients
Metformin, Glibenclamide -
Dosage Form
Tablet -
Uses
Diabetes Type 2 -
Dosage
Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: 1.25 glibenclamide/250mg metformin orally a day or every 12 hours. Dose must be adjusted according to patient’s condition after two weeks. Maximum dose of glibenclamide is 20mg and metformin is 2000mg a day. -
In case of Overdose
Overdose of glibenclamide can cause prolong hypoglycemia. Metformin overdose can cause hypotension. Consult your doctor for management of overdose. -
Missed Dose
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one. -
How To Use
Take it orally with water after breakfast or main meal. -
When Not to Use
Cannot be used in case of hypersensitivity to glibenclamide or any component of the formulation, do not use in type 1 diabetes mellitus or diabetic ketoacidosis, with or without coma, liver disease or frank jaundice, kidney impairment, pregnancy and breastfeeding. Metformin should not be used in case of hypersensitivity to the drug, metabolic acidosis, chronic heart, failure, myocardial infarction, diabetic ketoacidosis, severe renal disease, abnormal creatinine clearance resulting from shock, septicemia and lactation. -
Side Effects
Epigastric fullness Heartburn Nausea Vomiting Hypersensitivity reaction Hypoglycemia Hyponatremia Loss of appetite Diuresis Hemolytic anemia Cholestatic jaundice -
Precautions & Warnings
Glibenclamide presence in breast milk may cause hypoglycemia in infants. Severe hypoglycemia lasting 4 to 10 days may occur in infants born to mothers taking a sulfonylurea like; glibenclamide at the time of delivery. Assess renal function prior to initiation of this drug. If metformin-associated lactic acidosis is suspected, general supportive measures should be taken in a hospital setting, along with immediate discontinuation of this medicine. -
Food Interactions
Diet management along with this medicine indicated by your doctor is necessary for your health. Keep a strict check on your carbohydrate intake specially. Taking grapefruit along with this medicine could increase the accumulation of metformin in the liver and in result increases the risk of lactic acidosis. Taking metformin with a meal can reduce the chances of developing an upset stomach or gastric discomfort. -
Storage/Disposal
Store at 25°C. Protect from heat and moisture. -
Laboratory Screening
If you are diabetic, go for the following tests: Glucose Tolerance Test, Blood sugar test, Blood Glucose Fasting Test
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