Dapa-Met (5/1000mg) 14 Tablets

Dapagliflozin and Metformin work synergistically to manage type 2 diabetes. Dapagliflozin, an SGLT2 inhibitor, blocks the reabsorption of glucose in the kidneys, leading to increased glucose excretion and reduced blood sugar levels. It lowers blood glucose by promoting the elimination of glucose through urine. Metformin, a biguanide, primarily acts by suppressing glucose production in the liver, enhancing insulin sensitivity in peripheral tissues, and reducing intestinal glucose absorption. It inhibits gluconeogenesis and increases glucose uptake in muscles and fat cells, thereby lowering blood glucose levels. This combination therapy effectively reduces blood sugar levels through complementary mechanisms, providing improved glycemic control for patients with type 2 diabetes.

Dapagliflozin 5mg, Metformin 1000mg

SGLT2 inhibitor, Biguanide.

Tablet

The following are the uses of Dapagliflozin 5mg, Metformin 1000mg Tablet:

• Used for managing type 2 diabetes by controlling blood sugar levels.
• Used to reduce the risk of cardiovascular events in diabetic patients.
• Used to lower blood sugar by decreasing glucose production in the liver and improving insulin sensitivity.
• Used to aid in weight loss and improve glycemic control.
• Used to treat patients who have inadequate control with diet and exercise alone.
• Used as an adjunct to other diabetes medications for better blood sugar management.
• Used to delay the progression of prediabetes to type 2 diabetes in at-risk individuals.
• Used to improve overall metabolic health and reduce the complications associated with diabetes.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Dapagliflozin 5mg Take one tablet every day, with or without food.
• Metformin Hydrochloride 1000mg ,The recommended dose starts at 500mg twice a day, and your doctor may increase the dose after checking your glucose blood levels. The maximum usual dose is 3000mg per day.

In the case of an overdose of Dapagliflozin 5mg and Metformin 1000mg tablets, individuals may experience symptoms such as excessive urination, dizziness, rapid breathing, and dehydration. It is important to seek medical advice promptly if an overdose is suspected. Treatment for overdose may involve monitoring vital signs, fluid replacement, and supportive care. In severe cases, hospitalization and close observation might be necessary to manage potential complications.

In the case of a missed dose of Dapagliflozin 5mg, take it as soon as you remember, but if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Metformin 1000mg, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing routine. Do not double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track.

To take Dapagliflozin 5mg and Metformin 1000mg Tablet, swallow the tablet whole with a glass of water, preferably during or after a meal, exactly as prescribed by your healthcare provider, typically once or twice a day.

Following are the conditions or situations when Dapagliflozin 5mg and Metformin 1000mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Dapagliflozin, Metformin, or any of the tablet's components.
• Contraindicated in patients with severe kidney disease or those receiving dialysis.
• Not recommended for individuals with type 1 diabetes or diabetic ketoacidosis.
• Should not be used in patients with a history of a serious hypersensitivity reaction to any SGLT2 inhibitor.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with a history of a serious allergic reaction to Metformin or other related substances.
• Should not be used in patients with a recent history of heart attack, heart failure, or severe circulation problems.
• Contraindicated in individuals with a history of diabetic precoma.
• Not recommended for patients with impaired liver function or liver disease.
• Should be avoided in individuals with a history of alcohol abuse or heavy alcohol consumption.

The side effects of Dapagliflozin 5mg, Metformin 1000mg Tablet may include:

• Increased urination
• Thirst
• Low blood sugar (hypoglycemia)
• Nausea and vomiting
• Stomach pain or upset
• Diarrhea
• Skin reactions such as rash or itching
• Genital yeast infections

Following are the precautions and warnings for Dapagliflozin 5mg, Metformin 1000mg Tablet:

• Not recommended for individuals with known allergies to Dapagliflozin or Metformin or any other ingredients in the tablet.
• Patients with kidney problems should exercise caution and consult a doctor, as dosage adjustments might be necessary.
• Metformin can cause lactic acidosis, a serious condition; discontinue use if symptoms like nausea, vomiting, or stomach pain occur.
• Not suitable for individuals with a history of diabetic ketoacidosis.
• May cause dehydration and hypotension; monitor fluid intake and blood pressure regularly.
• Elderly patients may be more susceptible to the side effects, especially kidney-related issues.
• Exercise caution if you have a history of liver disease or heart problems.

Following are the drug interactions for Dapagliflozin 5mg and Metformin 1000mg Tablet:

• Dapagliflozin may increase the risk of hypoglycemia when used with insulin or other antidiabetic medications like sulfonylureas or glinides.
• Diuretics, especially loop diuretics, can enhance the diuretic effect of Dapagliflozin, leading to possible dehydration or electrolyte imbalances.
• Metformin's renal excretion may be impaired by cimetidine, ranitidine, and trimethoprim, potentially increasing the risk of lactic acidosis.
• Drugs that affect kidney function, such as ACE inhibitors or angiotensin receptor blockers, may require dosage adjustments when used with Metformin.
• Alcohol consumption can increase the risk of lactic acidosis when taking Metformin.
• Contrast dyes used in certain imaging procedures may temporarily impair kidney function, affecting Metformin elimination.
• Certain medications, like corticosteroids or beta-agonists, may increase blood glucose levels, reducing the effectiveness of Dapagliflozin and Metformin.

Following are the food interactions for Dapagliflozin 5mg and Metformin 1000mg Tablet:

• Avoid excessive alcohol consumption while taking these medications, as alcohol can affect blood sugar levels and interact with both drugs.
• Dapagliflozin can cause urinary glucose excretion, so monitoring carbohydrate intake is important to maintain stable blood sugar levels.
• Maintain a balanced diet, as Metformin's effectiveness can be influenced by the amount of glucose in the body.
• Avoid high-fat meals, as they may reduce the absorption of Dapagliflozin.
• Follow a consistent carbohydrate intake pattern to ensure the optimal efficacy of Metformin.
• Be cautious with foods containing high levels of potassium, as Dapagliflozin can increase potassium levels.
• Avoid grapefruit and grapefruit juice, as they may affect the metabolism of these drugs and increase the risk of side effects.
• Stay hydrated, as Metformin can sometimes cause lactic acidosis, and proper hydration is essential to prevent this rare but serious side effect.

Dapagliflozin 5mg and Metformin 1000mg Tablets should be stored in a cool, dry place, preferably at room temperature, and protected from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial to ensure the medication is stored away from heat sources, as high temperatures can impact its effectiveness. Always check the expiration date, and if the medication is expired or no longer needed, proper disposal is essential. Do not dispose of it in household garbage or pour it down the drain; instead, follow local guidelines or consult a healthcare professional for safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Dapagliflozin 5mg and Metformin 1000mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Take the tablet with a full glass of water to ensure proper swallowing.
• It is best to take these medications with food to minimize gastrointestinal side effects.
• Maintain a consistent schedule by taking your doses at the same time each day.
• Do not break, crush, or chew the tablets; swallow them whole for optimal effectiveness.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood sugar levels as instructed by your healthcare provider.

When taking Dapagliflozin and Metformin Hydrochloride, it is important to monitor your body's response to the medications to ensure they are working effectively. Your doctor will likely recommend regular lab tests to check various metrics, including blood sugar levels, hemoglobin A1C, lipid profile, kidney function, liver function, and electrolyte balance. Firstly, fasting and post-breakfast blood sugar levels will be monitored to ensure they are within a healthy range. This helps to assess how well your body is processing glucose. Secondly, your doctor will check your hemoglobin A1C (HbA1c) level, which provides an overall picture of your blood sugar control over the previous two to three months. Thirdly, as metformin has been associated with improvements in lipid profiles, your doctor will check your levels of cholesterol and triglycerides to monitor any beneficial changes and determine your risk of cardiovascular diseases. Regular kidney function tests will be conducted, as metformin is excreted by the kidneys. These tests may include blood tests for kidney enzymes and serum potassium levels. Periodic liver function tests are also recommended as metformin may occasionally cause liver damage, and tests may include liver enzyme measurements and bilirubin levels. Lastly, your doctor will assess your electrolyte levels, including sodium, potassium, and calcium, to ensure they remain within the normal range. These lab tests serve as a helpful tool to ensure that your body is responding well to the medications and to make any necessary adjustments to your treatment plan. It is important to consult with your doctor about the specific lab tests you need and how often you need to undergo them while taking Dapagliflozin and Metformin Hydrochloride.