Dapwiz (5mg) 10 Tablets

Dapagliflozin, the active ingredient in the 5mg tablet, acts as a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. Its primary mechanism of action involves blocking the reabsorption of glucose in the kidneys. Normally, SGLT2 proteins in the proximal tubule of the kidney facilitate the reabsorption of filtered glucose back into the bloodstream. However, dapagliflozin binds to these SGLT2 proteins, inhibiting their function. This inhibition leads to increased glucose excretion in the urine, effectively lowering blood glucose levels. By promoting the elimination of glucose through the urine, dapagliflozin helps reduce hyperglycemia and contributes to improved glycemic control in individuals with type 2 diabetes mellitus.

Dapagliflozin 5mg

SGLT2 inhibitor.

Tablet

The following are the uses of Dapagliflozin 5mg Tablet:

• Used for managing type 2 diabetes, helping control blood sugar levels.
• Used to lower the risk of heart-related issues in diabetic patients.
• Used to treat chronic kidney disease, improving kidney function.
• Used to reduce hospital admissions for heart failure.
• Used for weight loss, aiding in managing obesity.
• Used to lower blood pressure in some patients.
• Used to improve overall metabolic health and reduce insulin resistance.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Diabetes mellitus type 2- Adults- 5 mg once daily in the morning with or without food. Adolescents aged 17–18 years- 5 mg once daily in the morning with or without food
• Diabetes mellitus type 1- Adults and adolescents aged 17–18 years- Not recommended
• Heart failure- Adults- 5 mg once daily in the morning with or without food

In the case of an overdose of Dapagliflozin 5mg Tablets, it is important to seek medical advice promptly. Symptoms of an overdose may include dehydration, excessive urination, and dizziness. Prompt action is advised, such as contacting a healthcare professional or a poison control center for guidance on managing the overdose. The treatment may involve supportive care and monitoring, ensuring the patient's well-being and addressing any potential complications associated with the excess medication intake.

In the case of a missed dose of Dapagliflozin 5mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you miss several doses, consult your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions based on your specific condition and treatment plan.

To take Dapagliflozin 5mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning as directed by your healthcare provider, without crushing or chewing, and follow any dietary or lifestyle instructions given by your doctor for optimal effectiveness.

Following are the conditions or situations when Dapagliflozin 5mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Dapagliflozin or other SGLT2 inhibitors.
• Contraindicated in patients with severe kidney disease or those on dialysis.
• Not recommended for individuals with type 1 diabetes mellitus.
• Should not be used in patients with diabetic ketoacidosis (DKA), or at risk of DKA.
• Not suitable for individuals with a history of a serious hypersensitivity reaction to Dapagliflozin.
• Should not be taken by individuals with a recent history of stroke, heart attack, or bypass surgery.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with bladder cancer or those at high risk of bladder cancer.

The side effects of Dapagliflozin 5mg Tablet may include:

• Increased urination
• Genital yeast infections
• Urinary tract infections
• Thirstiness
• Low blood sugar (hypoglycemia)
• Nausea and vomiting
• Fatigue and dizziness
• Skin rashes or allergic reactions

Following are the precautions and warnings for Dapagliflozin 5mg Tablet:

• Not recommended for individuals with severe kidney problems, as it may worsen kidney function.
• Should be used with caution in patients with mild to moderate kidney impairment, and regular monitoring of kidney function is advised.
• May cause dehydration and low blood pressure, especially in elderly patients or those on a low-salt diet. Stay hydrated and seek medical advice if symptoms occur.
• Can increase the risk of genital and urinary tract infections, particularly in women. Promptly report any symptoms to your healthcare provider.
• Diabetic patients should monitor their blood sugar levels regularly, as Dapagliflozin may cause low blood sugar.
• Not recommended for patients with type 1 diabetes or diabetic ketoacidosis.
• May cause rare but serious allergic reactions. Seek immediate medical attention if you experience symptoms like rash, itching, or difficulty breathing.
• Inform your doctor about any other medications you are taking, as Dapagliflozin may interact with certain drugs.

Following are the drug interactions for Dapagliflozin 5mg Tablet:

• Concomitant use with diuretics or other medications that can lower blood pressure may increase the risk of hypotension.
• Dapagliflozin can enhance the effects of certain antihypertensive agents, leading to excessive blood pressure reduction.
• It may interact with loop diuretics, thiazide diuretics, and other SGLT2 inhibitors, increasing the risk of dehydration and electrolyte imbalances.
• Insulin or sulfonylureas may have their effects enhanced by Dapagliflozin, potentially causing hypoglycemia.
• Dapagliflozin can increase the risk of kidney injury when used with other nephrotoxic drugs, such as certain antibiotics and contrast agents.
• Monitoring is required when combining Dapagliflozin with ACE inhibitors or ARBs, as it may further affect kidney function.
• The effectiveness of Dapagliflozin may be reduced when used with corticosteroids or beta-adrenergic agonists.

Following are the food interactions for Dapagliflozin 5mg Tablet:

• Avoid consuming large amounts of alcohol as it can interact with Dapagliflozin and may increase the risk of side effects, including low blood sugar and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Dapagliflozin, potentially leading to increased drug levels in the body.
• This medication may cause dehydration, so ensure you stay well-hydrated and maintain a balanced fluid intake.
• Dapagliflozin can increase the risk of genital and urinary tract infections; ensure a healthy diet rich in vitamin C and probiotics to support urinary health.
• Avoid high-potassium foods like bananas, oranges, and tomatoes if you have kidney problems, as Dapagliflozin can increase potassium levels.
• Monitor your blood sugar levels regularly, especially when starting the medication, as Dapagliflozin can cause low blood sugar, affecting dietary choices.
• No significant interactions have been reported with specific foods, but a balanced diet is recommended for overall health.
• Always follow your healthcare provider's instructions for taking Dapagliflozin and managing your diet.

Dapagliflozin 5mg Tablets should be stored in a cool, dry area, ideally at room temperature, which should be between 68°F and 77°F (20°C and 25°C). Ensure the tablets are kept in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture or direct sunlight. It's crucial to keep this medication away from children and pets by storing it in a secure location. Pay attention to the expiration date on the packaging, and if the tablets are past their prime, do not flush them down the toilet or pour them into a drain. Instead, consult your pharmacist or local waste disposal company for guidance on how to safely dispose of expired or unused medication, as improper disposal can pose environmental risks.

Following are the quick tips for Dapagliflozin 5mg Tablet:

• Consult your doctor before starting this medication and provide your complete medical history.
• Take the tablet as directed by your doctor, typically once daily with or without food.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent schedule for taking the medication to ensure its effectiveness.
• Regularly monitor your blood sugar levels as advised by your doctor.
• Inform your doctor if you have any kidney or liver problems, or if you are pregnant or breastfeeding.
• Store the medication at room temperature, away from moisture and light.

Dapagliflozin is a medication that helps lower blood sugar levels in patients with type 2 diabetes. Your doctor may prescribe this medication, but it is important to be aware of the necessary accompanying lab tests. These tests are implemented to manage the medication effectively and correspondingly monitor your overall health. Firstly, due to the nature of Dapagliflozin and its impact on blood sugar levels, it is necessary for your doctor to monitor these levels on a regular basis. This is to ensure that the medication is working effectively and that your blood sugar remains in a safe and healthy range. This monitoring can be done through HbA1c testing, which measures your blood sugar levels over a period of 2 to 3 months, or self-monitoring of blood glucose, which tracks your blood sugar levels daily. The medication Dapagliflozin is excreted through the kidneys, so it is important to monitor kidney function through blood tests to ensure they are functioning properly. Changes in weight and body mass index (BMI) can also impact blood sugar control, so these may be monitored as well. Cholesterol levels may be assessed through a lipid panel, as Dapagliflozin has been shown to positively impact cholesterol levels. Furthermore, it is important to monitor cardiovascular risk factors, as diabetes can lead to heart problems and other complications. Potassium levels may also be monitored through blood tests to ensure they remain within a safe range, as Dapagliflozin can rarely cause levels of potassium in the blood to rise. These lab tests provide your doctor with the information they need to effectively monitor the effectiveness of the medication and its impact on your overall health.