DARDUM INJ 150MG

Cefoperazone, the active component in Cefoperazone 150MG Injection, is a third-generation cephalosporin antibiotic. It exerts its bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. Cefoperazone binds to and inactivates specific penicillin-binding proteins (PBPs) located inside the bacterial cell, which are essential for cross-linking peptidoglycan strands during cell wall formation. This disruption leads to a weakened cell wall and ultimately results in cell lysis and death. Cefoperazone has a broad spectrum of activity, covering a wide range of gram-positive and gram-negative bacteria, including many strains resistant to other beta-lactam antibiotics.

Cefoperazone 150MG

Third-generation cephalosporin.

Injection

The following are the uses of Cefoperazone 150MG Injection:

• Used for treating severe bacterial infections like pneumonia, skin and soft tissue infections, and abdominal infections.
• Used for controlling infections caused by susceptible bacteria before surgery.
• Used to treat bone and joint infections, particularly those associated with surgery or trauma.
• Used in the management of gynecological infections, such as pelvic inflammatory disease.
• Used for treating bacterial meningitis and preventing its complications.
• Used for managing infections in patients with weakened immune systems, such as those undergoing chemotherapy.
• Used for treating infections in various body systems, including the respiratory, urinary, and gastrointestinal tracts.
• Used as an alternative therapy for patients allergic to penicillin-based antibiotics.

In the case of an overdose of Cefoperazone 150MG Injection, it is important to recognize the signs and act promptly. Symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or respiratory distress. If an overdose is suspected, seek medical assistance immediately. Treatment for overdose may involve managing symptoms, providing supportive care, and ensuring the patient's vital signs are stable. Quick action can help prevent potential complications.

In the case of a missed dose of Cefoperazone 150MG Injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without compromising its effectiveness. Always consult your doctor or pharmacist if you have any concerns or questions about missed doses.

To administer Cefoperazone 150MG Injection, prepare the medication by drawing the prescribed dose into a syringe, then inject it into a muscle or intravenous line as directed by your healthcare provider, ensuring slow and controlled administration.

Following are the conditions/situations when Cefoperazone 150MG Injection should not be used:

• Should not be used in individuals with a confirmed or suspected allergy to Cefoperazone, other cephalosporin antibiotics, or any of its components.
• Contraindicated in patients with a history of severe allergic reactions to penicillins, as there may be cross-reactivity.
• Not recommended for patients with severe renal impairment or kidney failure, as dosage adjustments are necessary.
• Should be avoided in patients with a history of severe gastrointestinal diseases, especially colitis.
• Not suitable for patients with a history of seizures or conditions that increase the risk of seizures.
• Contraindicated in newborns, especially premature babies, due to the risk of bilirubin encephalopathy.
• Should be used with caution and avoided in patients with a history of prolonged QT interval or conditions that may affect heart rhythm.

The side effects of Cefoperazone 150MG Injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rashes or itching
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Confusion or disorientation
• Increased heart rate
• Injection site reactions (pain, swelling, redness)
• Changes in blood cell counts

Following are the precautions and warnings for Cefoperazone 150MG Injection:

• This medication should not be used in patients with a known allergy to Cefoperazone or other cephalosporin antibiotics.
• Cefoperazone should be used with caution in patients with a history of kidney or liver disease, as it may require dosage adjustments.
• It is important to complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
• Patients with a history of gastrointestinal diseases, especially colitis, should be closely monitored while on this medication.
• Cefoperazone may cause false-positive results for certain medical tests, inform your doctor about the medication before any tests.
• This medication may cause allergic reactions, seek immediate medical attention if you experience severe symptoms like difficulty breathing or hives.
• Cefoperazone should be used with caution in elderly patients as they may be more susceptible to its side effects.

Following are the drug interactions for Cefoperazone 150MG Injection:

• Probenecid can decrease the renal excretion of Cefoperazone, potentially increasing its serum levels.
• May reduce the effectiveness of oral contraceptives, requiring alternative birth control methods.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, diuretics) may increase the risk of renal toxicity.
• Cefoperazone may enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
• Can affect the metabolism of drugs metabolized by the liver, such as phenytoin, leading to increased drug levels.
• Concurrent use with other antibiotics like aminoglycosides may increase the risk of ototoxicity and nephrotoxicity.
• May decrease the effectiveness of live vaccines, so vaccination schedules should be adjusted accordingly.

Following are the food interactions for Cefoperazone 150MG Injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of gastrointestinal side effects and affect the effectiveness of Cefoperazone.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the absorption of Cefoperazone, leading to reduced effectiveness.
• Avoid high-fat meals as they can delay the absorption of Cefoperazone, potentially affecting its optimal concentration in the blood.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of Cefoperazone; consider taking the medication at least 2 hours before or after consuming dairy.
• Caffeine-rich beverages like coffee and tea may increase the metabolism of Cefoperazone, potentially reducing its effectiveness. Consider limiting caffeine intake.
• Avoid iron-rich foods or supplements close to the time of medication as they can decrease the absorption of Cefoperazone.
• Vitamin C supplements or citrus fruits high in vitamin C may alter the pH of urine, potentially affecting the excretion of Cefoperazone metabolites. Consume them in moderation.
• Maintain a balanced diet to support overall health and ensure the medication's effectiveness.

Cefoperazone 150MG Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The injection vials should be kept intact and tightly sealed to maintain their sterility and prevent contamination. It is crucial to store the medication at room temperature, avoiding exposure to extreme heat or cold. Always check the expiration date before administering the injection, and never use it if it has expired. Dispose of used or empty vials safely by following local guidelines for medical waste disposal, ensuring they are not accessible to children or pets. Proper disposal helps protect the environment and prevents accidental exposure to the medication.

Following are the quick tips for Cefoperazone 150MG Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medicine's label for dosage and expiration before use.
• Cefoperazone is typically given intravenously, follow the prescribed infusion rate.
• Complete the full course of treatment as prescribed by your doctor.
• Inform your doctor if you have allergies or kidney/liver issues before administration.
• Store the injection as directed; protect it from light and moisture.
• Do not reuse needles or syringes; dispose of them safely.