DAY NURSE SYP 240ML IMP

Pseudoephedrine primarily acts as a sympathomimetic agent, stimulating alpha-adrenergic receptors in the respiratory tract, leading to vasoconstriction and decreased blood flow to the nasal mucosa, which reduces congestion. Paracetamol, also known as acetaminophen, exerts its analgesic and antipyretic effects by inhibiting the synthesis of prostaglandins and affecting the pain signaling pathways in the central nervous system. Pholcodine, an opioid cough suppressant, binds to opioid receptors in the brain, suppressing the cough reflex by increasing the cough threshold and reducing the urge to cough. When combined in a syrup or suspension, these active ingredients work together to provide relief from nasal congestion, pain, fever, and cough by targeting specific receptors and pathways in the body.

Analgesic/Antipyretic and Antihistamine

Suspension

The following are the uses of Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension:

• Used for temporarily relieving congestion caused by colds, allergies, or sinus irritation.
• Used for reducing fever and providing pain relief for mild to moderate aches and pains.
• Used for suppressing dry coughs and reducing the urge to cough, providing temporary relief from coughing symptoms.
• Used for treating upper respiratory tract congestion, helping to open blocked sinuses and nasal passages.
• Used for managing symptoms of the common cold, flu, or allergies, including nasal congestion, sinus pressure, and headaches.
• Used for providing symptomatic relief from upper respiratory tract congestion, allowing easier breathing.
• Used for reducing inflammation in the nasal passages and sinuses, helping to alleviate discomfort.
• Used for controlling symptoms of allergic rhinitis, such as runny nose, sneezing, and itchy, watery eyes.

In the case of an overdose of Pseudoephedrine, symptoms may include rapid breathing, anxiety, and increased blood pressure. For Paracetamol, liver damage and abdominal pain can occur. Pholcodine Syrup/Suspension overdose can lead to severe drowsiness, nausea, and respiratory depression. Prompt medical attention is necessary for all three medications, with treatment focused on managing symptoms and providing supportive care. It is crucial to seek medical advice for appropriate management.

In the case of a missed dose of Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to safely resume your medication. It is important to adhere to the prescribed dosing schedule for optimal effectiveness.

To administer Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or dosing cup, and take it orally, following the dosage instructions provided by your healthcare professional, typically once every 4-6 hours, with or without food, without exceeding the recommended daily limit.

Here are the conditions or situations when Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension should not be used:

• Avoid in individuals with known allergies or hypersensitivity to Pseudoephedrine, Paracetamol, or Pholcodine, or any of the excipients in the medication.
• Not suitable for patients with narrow-angle glaucoma.
• Contraindicated in individuals with severe cardiovascular disease, including uncontrolled hypertension, coronary artery disease, and cardiac arrhythmias.
• Should not be used in patients with severe liver impairment or active liver disease.
• Avoid in patients with severe kidney disease or end-stage renal disease.
• Not recommended for individuals with difficulty in urination due to prostate enlargement.
• Do not administer to patients with a history of seizures or conditions that lower the seizure threshold.
• Should be avoided in patients with a history of stomach ulcers or gastrointestinal bleeding.
• Contraindicated in infants under 2 years of age.

The side effects of Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Dry mouth
• Constipation
• Drowsiness or sedation
• Confusion (especially in elderly patients)
• Allergic reactions (such as skin rash, itching, or difficulty breathing)
• Increased heart rate or blood pressure

Following are the precautions and warnings for Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension:

• This medication should not be used in patients with known allergies or hypersensitivity to any of its components, including Pseudoephedrine, Paracetamol, or Pholcodine.
• Individuals with narrow-angle glaucoma, severe coronary artery disease, or those who have recently had a heart attack should avoid this medication.
• Caution is advised in patients with diabetes, liver or kidney disease, and thyroid problems, as this medication may affect blood sugar levels and organ function.
• The syrup/suspension should be used with caution in the elderly and children, as they may be more sensitive to its effects.
• Avoid driving or operating heavy machinery until you know how this medication affects you, as it may cause drowsiness or dizziness.
• Do not exceed the recommended dosage, as excessive use of Paracetamol can lead to liver damage.
• If symptoms persist or worsen, discontinue use and consult a healthcare professional immediately.

Following are the drug interactions for Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension:

• Monoamine oxidase inhibitors (MAOIs) should not be used concurrently, as they can increase blood pressure and cause cardiovascular side effects.
• Tricyclic antidepressants and SSRIs may increase the risk of cardiovascular adverse events when combined with pseudoephedrine.
• Antihypertensives, Pseudoephedrine can reduce the effectiveness of these medications, leading to increased blood pressure.
• Paracetamol may prolong the effects of warfarin and increase the risk of bleeding.
• Chronic alcohol use with paracetamol can increase the risk of liver damage.
• Pholcodine may interact with other central nervous system depressants, such as benzodiazepines, increasing sedation.
• Antihistamines may enhance the sedative effects of pholcodine.

Following are the food interactions for Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they may interfere with the metabolism of the medication, particularly Pholcodine, potentially leading to increased side effects.
• Alcohol should be used cautiously with this medication. It can enhance the sedative effects of Pholcodine and may increase the risk of liver damage when combined with Paracetamol, especially with chronic alcohol use.
• Caffeine-containing products should be limited as Pseudoephedrine can increase blood pressure and heart rate, and caffeine may exacerbate these effects, causing jitters or anxiety.
• High-fat meals can slightly delay the absorption of Paracetamol, but it generally does not significantly impact the effectiveness of the medication.
• Avoid consuming large amounts of sugary foods or drinks while taking this syrup, as it may contribute to dental issues.
• Spicy foods should be approached with caution as they might irritate the throat, especially when combined with Pholcodine, which can cause dryness and discomfort.
• It is generally advisable to maintain a balanced diet and stay well-hydrated to support overall health and aid in the recovery process.
• Always consult your healthcare provider for specific dietary recommendations based on your medical history and condition.

Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension should be stored in a cool, dry area, preferably in a medicine cabinet or a similar storage space, away from direct sunlight and moisture. Keep the bottle tightly sealed to maintain its integrity and effectiveness. It is crucial not to store the medication in the bathroom or near heat sources, as temperature fluctuations can impact its quality. Always adhere to the expiration date on the packaging, and dispose of any unused or expired syrup responsibly. Avoid disposing of it through the sink or toilet; instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension:

• Always read the patient information leaflet provided with the medication.
• Consult your pharmacist or healthcare provider if you have any questions or concerns.
• Take the prescribed dose as directed by your healthcare provider.
• Do not exceed the recommended dosage, as it may lead to serious side effects.
• Avoid alcohol consumption while taking this medication.
• Store the medication in a cool, dry place, away from direct sunlight.
• Keep a record of your doses to ensure you don't miss any.
• Inform your doctor if you experience any unusual symptoms or reactions.