DAYCOR SYP

Paracetamol, the active ingredient in the syrup/suspension, acts primarily by inhibiting the synthesis of prostaglandins, which are involved in pain and fever pathways. It selectively blocks cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system, reducing the production of prostaglandin E2, which is responsible for pain and inflammation. Pholcodine, on the other hand, is an opioid-based cough suppressant that acts centrally by binding to opioid receptors in the brainstem, which reduces the sensitivity of the cough reflex, thereby suppressing the urge to cough.

Antitussive-analgesic

Suspension

The following are the uses of Paracetamol, pholcodine Syrup/Suspension:

• Used for relieving mild to moderate pain such as headaches, toothaches, and post-vaccination fever.
• Used to reduce high temperatures and ease discomfort associated with fevers.
• Used to alleviate symptoms of upper respiratory tract infections, including sore throat and cough.
• Used to suppress dry or unproductive coughs, providing temporary relief.
• Used to manage post-operative pain and discomfort.
• Used to treat pain and inflammation related to conditions like arthritis.
• Used for easing discomfort during teething in infants and young children.
• Used as an adjunct to other medications for comprehensive pain management.

In the case of an overdose of Paracetamol and pholcodine Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and, in severe cases, liver damage or respiratory depression. Prompt medical intervention is necessary, and treatment may involve administering activated charcoal to prevent further absorption and supportive care to manage symptoms. Quick action can help mitigate the potentially harmful effects of an overdose.

In the case of a missed dose of Paracetamol and pholcodine Syrup/Suspension, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For children, it is important to consult a healthcare professional to determine the appropriate course of action for any missed doses.

To administer Paracetamol, pholcodine Syrup/Suspension, shake the bottle well, measure the prescribed dose with the provided measuring cup, and take it orally as directed by your healthcare professional, typically every 4 to 6 hours as needed, but not exceeding the maximum daily dosage as advised.

Following are the conditions/situations when Paracetamol, pholcodine Syrup/Suspension should not be used:

• Avoid use in patients with a known allergy or hypersensitivity to paracetamol or pholcodine or any of the excipients in the medication.
• Not suitable for patients with severe liver impairment or active liver disease.
• Should not be used in patients with severe respiratory conditions such as severe chronic bronchitis or severe asthma.
• Contraindicated in patients with a history of respiratory depression or severe breathing problems.
• Avoid use in patients with a known or suspected gastrointestinal obstruction, as the medication may worsen the condition.
• Not recommended for individuals with a history of alcohol or drug abuse, as it may contain alcohol.
• Should not be used in patients with a rare hereditary problem of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency.
• Do not administer to infants under 6 years old due to the risk of respiratory depression.
• Avoid use during pregnancy or breastfeeding, unless clearly needed and under medical supervision.

The side effects of Paracetamol, pholcodine Syrup/Suspension may include:

• Nausea and vomiting
• Drowsiness or dizziness
• Dry mouth
• Constipation
• Skin rash or itching
• Difficulty in urination
• Respiratory depression (slowed breathing)
• Allergic reactions (rarely)

Following are the precautions and warnings for Paracetamol, pholcodine Syrup/Suspension:

• Do not exceed the recommended dosage, as Paracetamol overdose can cause severe liver damage.
• This medication should not be used for prolonged periods without medical supervision.
• Individuals with liver or kidney disease should exercise caution and consult a healthcare professional before use.
• Alcohol consumption should be avoided as it may increase the risk of liver damage when combined with Paracetamol.
• Pholcodine may cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for children under 6 years old, and for older children, it should be used under medical supervision.
• If symptoms persist or worsen, discontinue use and seek medical advice immediately.
• Inform your doctor about any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Paracetamol, pholcodine Syrup/Suspension:

• Alcohol may increase the risk of liver damage when used with paracetamol, especially with excessive alcohol consumption.
• Paracetamol can prolong the effects of warfarin and other anticoagulants, requiring close monitoring of blood clotting times.
• It may reduce the effectiveness of antiepileptic drugs, such as phenytoin and carbamazepine, requiring dosage adjustments.
• Pholcodine can interact with monoamine oxidase inhibitors (MAOIs), leading to increased risk of side effects.
• When combined with other central nervous system depressants, such as benzodiazepines or opioids, it can enhance their effects and increase the risk of respiratory depression.
• The syrup may decrease the absorption of oral contraceptives, potentially reducing their effectiveness.
• Caution is advised with drugs that are highly protein-bound, as paracetamol may displace them, altering their distribution and effects.

Following are the food interactions for Paracetamol, pholcodine Syrup/Suspension:

• Alcohol consumption should be avoided as it may increase the risk of liver damage, especially with prolonged or excessive use of Paracetamol.
• Grapefruit juice should be used cautiously as it may interfere with the metabolism of pholcodine, potentially leading to increased side effects.
• Caffeinated beverages should be limited as they may reduce the effectiveness of Paracetamol in relieving pain.
• High-fat meals may delay the absorption of Paracetamol, but it is generally well-tolerated with or without food.
• Avoid consuming large amounts of foods rich in tyramine (aged cheeses, cured meats) as they may interact with pholcodine and increase blood pressure.
• Spicy foods might irritate the throat and exacerbate coughing, so it's best to avoid them when taking pholcodine.
• Ensure adequate fluid intake to maintain hydration, especially when taking this medication.
• Certain herbal teas with expectorant properties may enhance the cough-suppressing effect of pholcodine.

Paracetamol, pholcodine Syrup/Suspension should be stored in a secure location, preferably in a locked medicine cabinet, away from direct sunlight, heat, and moisture. Room temperature is generally suitable for storage. Keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to dispose of any unused or expired medication responsibly; do not flush it or pour it down the drain. Contact your local pharmacist or healthcare provider for guidance on proper disposal methods in your area. Always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for Paracetamol, Pholcodine Syrup/Suspension:

• Administer the medication as directed by your healthcare professional for effective relief.
• Before each use, shake the bottle vigorously to maintain a uniform mixture.
• Consume the syrup with water, avoiding tea, coffee, or dairy for better absorption.
• Adhere to a consistent dosing schedule to maintain therapeutic levels.
• If stomach irritation occurs, consider taking it with food or post-meals.
• Store the syrup away from children to prevent accidental consumption.
• Always consult your doctor or pharmacist if you have any concerns or questions.