DEANXIT TAB

Flupenthixol and Melitracen is a combination medication primarily used for the treatment of depression. Flupenthixol, a thioxanthene derivative, acts as a potent dopamine antagonist, particularly at D2 receptors, thereby inhibiting dopamine transmission in various brain regions. This dopamine-blocking action is thought to contribute to its antidepressant effects, although the exact mechanism is complex and not fully understood. Melitracen, a tricyclic antidepressant, enhances the action of neurotransmitters like serotonin and norepinephrine by inhibiting their reuptake, leading to increased concentrations in the synaptic cleft, which helps improve mood and alleviate depressive symptoms. The combination of these two components is believed to provide a synergistic effect in treating depression, with flupenthixol addressing the psychotic and anxiety-related symptoms and melitracen targeting the core depressive symptoms.

Flupenthixol, Melitracen

Antipsychotic, Antidepressant

Tablet

The following are the uses of Flupenthixol, Melitracen Tablet:

• Used for treating depression, especially when accompanied by anxiety and restlessness.
• Used for managing symptoms of schizophrenia, including hallucinations and delusions.
• Used to alleviate severe behavioral problems and aggression.
• Used for controlling symptoms of mania in bipolar disorder.
• Used for relieving severe anxiety and tension.
• Used to reduce nausea and vomiting, particularly in palliative care.
• Used for managing severe itching and skin disorders.

In the case of an overdose of Flupenthixol and Melitracen Tablets, individuals may experience severe symptoms such as drowsiness, confusion, and an irregular heartbeat. It is important to seek medical assistance promptly if an overdose is suspected. Other potential signs include muscle stiffness, difficulty breathing, and a significant drop in blood pressure. Quick action can help prevent serious complications, and medical professionals should be informed about the specific medications involved.

In the case of a missed dose of Flupenthixol and Melitracen Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for advice on how to safely resume your medication and adjust your dosing schedule.

To take Flupenthixol, Melitracen Tablet, swallow the tablet whole with a glass of water, preferably in the morning or as directed by your healthcare professional, following the prescribed dosage and treatment duration for your specific condition.

Here are the conditions or situations when Flupenthixol and Melitracen Tablet should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Flupenthixol, Melitracen, or any other tricyclic antidepressants.
• Contraindicated in individuals with severe central nervous system (CNS) disorders or those who have recently had a heart attack.
• Not suitable for patients with severe liver or kidney impairment.
• Should be avoided in individuals with a history of seizures or epilepsy.
• Contraindicated during pregnancy, especially in the first trimester, due to potential risks to the fetus.
• Not recommended for breastfeeding mothers as it may pass into breast milk and harm the nursing infant.
• Should not be used in children and adolescents under 18 years of age.
• Avoid in patients with narrow-angle glaucoma.
• Do not use in individuals with a history of bone marrow depression or blood disorders.
• Should be discontinued if the patient develops symptoms of neuroleptic malignant syndrome (NMS).

The side effects of Flupenthixol, Melitracen Tablet may include:

• Dry mouth
• Blurred vision
• Constipation
• Dizziness or lightheadedness
• Sleep disturbances (insomnia or excessive sleepiness)
• Skin rashes or itching
• Restlessness or akathisia (feeling of inner restlessness)
• Muscle stiffness or tremors

Following are the precautions and warnings for Flupenthixol, Melitracen Tablet:

• This medication is not suitable for individuals with a known allergy or sensitivity to Flupenthixol or Melitracen or any of the excipients in the tablet.
• Patients with a history of seizures or epilepsy should exercise caution, as this medication may lower the seizure threshold.
• It may cause orthostatic hypotension, so caution is advised in patients with cardiovascular disease or those who may be at risk of falls.
• Flupenthixol and Melitracen can cause anticholinergic effects; therefore, caution is warranted in patients with glaucoma, urinary retention, or gastrointestinal obstruction.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be necessary.
• Patients should avoid sudden discontinuation of the medication to prevent withdrawal symptoms. Taper the dose gradually under medical supervision.
• This medication may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them.

Following are the drug interactions for Flupenthixol, Melitracen Tablet:

• Alcohol and other central nervous system depressants, such as opioids or benzodiazepines, can increase the risk of respiratory depression and sedation when used with this medication.
• Flupenthixol may interact with antihypertensive drugs, leading to increased hypotensive effects. Close monitoring is required.
• This medication may enhance the sedative effects of antihistamines, causing increased drowsiness and impaired coordination.
• The effects of anticoagulants may be altered, potentially increasing the risk of bleeding. Regular monitoring of coagulation parameters is advised.
• Concomitant use with other antipsychotics or antidepressants can lead to additive pharmacological effects and increased side effects.
• Drugs that inhibit CYP2D6 enzyme, such as quinidine or bupropion, may increase the levels of flupenthixol, requiring dosage adjustments.
• Flupenthixol may interfere with the metabolism of certain medications metabolized by CYP450 enzymes, affecting their plasma concentrations.

Following are the food interactions for Flupenthixol, Melitracen Tablet:

• Avoid consuming alcohol as it can increase the sedative effects and lead to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of the medication, potentially increasing the drug concentration in the body.
• Caffeine-containing products should be limited as they can exacerbate anxiety and restlessness, which are potential side effects of the medication.
• Avoid high-fat meals as they may delay the absorption of the drug, affecting its onset of action.
• Foods rich in tyramine (aged cheeses, cured meats, fermented foods) should be consumed with caution as they may interact with the medication and increase blood pressure.
• Do not consume salt substitutes or potassium-rich foods without medical advice, as the medication can affect potassium levels.
• Always take the medication with a full glass of water to aid in swallowing and ensure proper absorption.
• Consult your healthcare provider for personalized advice regarding dietary restrictions and potential food interactions.

Flupenthixol, Melitracen Tablets should be stored in a secure and dry location, preferably in their original packaging, at room temperature, away from heat and direct sunlight. It is crucial to keep the tablets out of reach of children and pets to prevent accidental ingestion. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult a pharmacist who can provide guidance on safe disposal methods, ensuring that the medication is disposed of responsibly without causing harm to the environment. Proper storage and disposal practices are essential to maintain the integrity of the medication and protect the well-being of individuals and the ecosystem.

Following are the quick tips for Flupenthixol, Melitracen Tablet:

• Consult a doctor for prescription and dosage instructions.
• Swallow the tablet whole with water; do not crush or chew.
• Take the tablet at the same time each day for consistency.
• Avoid alcohol consumption while on this medication.
• Inform your doctor about any other medications you are taking.
• Do not stop taking the medication without medical advice.
• Store the tablets in a cool, dry place, away from sunlight.
• Take the tablet as directed by your doctor, typically once or twice daily.
• Ensure you understand the dosage instructions and duration of treatment.
• Do not exceed the prescribed dose, and do not take it for longer than recommended.
• Avoid activities requiring mental alertness until you know how the medication affects you.
• Inform your doctor if you experience any severe side effects or allergic reactions.
• Store Melitracen tablets at room temperature, away from moisture and heat.
• Keep this medication out of reach of children and pets.