Debritone (20mg/5ml) 120ml Elixer

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Manufacturer XENON PHARMACEUTICALS
Generic Name Phenobarbitone

Product Information

Description

Phenobarbitone is a barbiturate that enhances the activity of gamma-aminobutyric acid (GABA) at GABA-A receptors in the central nervous system. This increases the influx of chloride ions into neurons, leading to hyperpolarization and reduced neuronal excitability, which has anticonvulsant and sedative effects.
Ingredients

Phenobarbitone
Drug Class

Barbiturate
Dosage Form

Elixir
Uses

It is indicated in All forms of epilepsy except typical absence seizures and status epilepticus
Dosage
Debritone dosage for the indication of insomnia and seizure control, duration as prescribed:
- Adults - 5-10 ml at bedtime.
- Children - 1-5 ml as directed.
In case of Overdose

Overdose can lead to severe sedation or respiratory depression. Seek immediate emergency medical care.
Missed Dose

If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.
How To Use

Taken orally as prescribed, usually once or twice daily. Follow the dosage instructions and schedule.
When Not to Use
Phenobarbitone should not be used if:
- Hypersensitivity
- Severe liver impairment
- History of drug abuse
Side Effects

Agranulocytosis . anticonvulsant hypersensitivity syndrome . behaviour abnormal . bone disorders . bone fracture . cognitive impairment. confusion . depression . drowsiness .folate deficiency . hepatic disorders
Precautions & Warnings

Avoid in Acute porphyrias p. 1120 . children . debilitated . elderly . history of alcohol abuse . history of drug abuse .respiratory depression (avoid if severe)
Drug Interactions
The drug interactions with phenobarbitone include:
- CYP450 Inducers (e.g., rifampin) – Can decrease phenobarbitone levels.
- CNS Depressants (e.g., alcohol) – Can enhance CNS depressant effects.
Food Interaction

Phenobarbitone has no documented food interactions that affect its efficacy or safety.
Storage/Disposal

Phenobarbitone should be stored at room temperature, away from light and moisture. Keep it in its original container and out of reach of children. Dispose of expired or unused Phenobarbitone according to local disposal guidelines or through a drug take-back program.