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Debritone (20mg/5ml) 120ml Elixer
- Manufacturer XENON PHARMACEUTICALS
- Generic Name Phenobarbitone
Healthwire Pharmacy Ratings & Reviews (1500+)
Product Information
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Description
Phenobarbitone is a barbiturate that enhances the activity of gamma-aminobutyric acid (GABA) at GABA-A receptors in the central nervous system. This increases the influx of chloride ions into neurons, leading to hyperpolarization and reduced neuronal excitability, which has anticonvulsant and sedative effects.
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Ingredients
Phenobarbitone -
Drug Class
Barbiturate
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Dosage Form
Elixir -
Uses
It is indicated in All forms of epilepsy except typical absence seizures and status epilepticus -
Dosage
Debritone dosage for the indication of insomnia and seizure control, duration as prescribed:
- Adults - 5-10 ml at bedtime.
- Children - 1-5 ml as directed.
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In case of Overdose
Overdose can lead to severe sedation or respiratory depression. Seek immediate emergency medical care.
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Missed Dose
If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.
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How To Use
Taken orally as prescribed, usually once or twice daily. Follow the dosage instructions and schedule.
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When Not to Use
Phenobarbitone should not be used if:
- Hypersensitivity
- Severe liver impairment
- History of drug abuse
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Side Effects
Agranulocytosis . anticonvulsant hypersensitivity syndrome . behaviour abnormal . bone disorders . bone fracture . cognitive impairment. confusion . depression . drowsiness .folate deficiency . hepatic disorders -
Precautions & Warnings
Avoid in Acute porphyrias p. 1120 . children . debilitated . elderly . history of alcohol abuse . history of drug abuse .respiratory depression (avoid if severe) -
Drug Interactions
The drug interactions with phenobarbitone include:
- CYP450 Inducers (e.g., rifampin) – Can decrease phenobarbitone levels.
- CNS Depressants (e.g., alcohol) – Can enhance CNS depressant effects.
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Food Interactions
Phenobarbitone has no documented food interactions that affect its efficacy or safety.
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Storage/Disposal
Phenobarbitone should be stored at room temperature, away from light and moisture. Keep it in its original container and out of reach of children. Dispose of expired or unused Phenobarbitone according to local disposal guidelines or through a drug take-back program.
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