DELTARHINOL NASAL SPRAY

Ephedrine primarily acts as a stimulant on the alpha and beta-adrenergic receptors. It stimulates these receptors, leading to bronchodilation by relaxing the smooth muscles surrounding the airways. Naphazoline, a sympathomimetic amine, exerts its action by selectively binding to and activating alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activation causes vasoconstriction, thereby reducing nasal congestion and associated symptoms. Fluprednisolone, a synthetic corticosteroid, works by inhibiting the production of various inflammatory mediators. When administered as a spray, it reduces inflammation in the nasal passages by suppressing the release of histamine, leukotrienes, and other inflammatory substances, providing relief from nasal symptoms.

Ephedrine, Naphazoline, Fluprednisolone

Sympathomimetic and Imidazole andCorticosteroid

Spray

The following are the uses of Ephedrine, Naphazoline, Fluprednisolone Spary:

• Used for temporary relief of congestion due to colds, allergies, or sinus irritation.
• Used to reduce nasal swelling and provide relief from sinus pressure and headaches.
• Used for the short-term treatment of allergic and inflammatory conditions in the eyes, such as allergic conjunctivitis.
• Used to provide short-term relief from inflammation and pain in the mouth and throat.
• Used for the short-term treatment of inflammation and pain in the nose, such as after nasal surgery or injuries.
• Used for the temporary relief of minor skin irritations, insect bites, and rashes.
• Used to temporarily relieve symptoms of asthma and chronic bronchitis when used as an inhaler.

In the case of an overdose of Ephedrine, Naphazoline, and Fluprednisolone Spray, individuals may experience severe symptoms such as rapid heartbeat, high blood pressure, tremors, and even seizures. An overdose of Ephedrine can lead to a dangerous increase in heart rate and blood pressure, while Naphazoline, when ingested in excess, may cause central nervous system depression. Fluprednisolone Spray, if used excessively, can result in systemic corticosteroid effects. Prompt medical intervention is vital in managing these overdoses to prevent potential complications.

In the case of a missed dose of Ephedrine, take it as soon as you remember, but if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. For Naphazoline, if you miss a dose, apply it as soon as you remember, but avoid applying a double dose to make up for the missed one. With Fluprednisolone Spray, if you forget to use it, administer the missed dose as soon as possible, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

To use the Ephedrine, Naphazoline, and Fluprednisolone spray, gently shake the bottle, and administer the prescribed number of sprays into each nostril, typically once or twice daily, following the instructions provided by your healthcare professional or the package insert, ensuring proper dosage and application for optimal effectiveness.

Following are the conditions/situations when Ephedrine, Naphazoline, Fluprednisolone Spray should be avoided:

• Not recommended for individuals with a known allergy to any of the active ingredients, including Ephedrine, Naphazoline, or Fluprednisolone.
• Should not be used in patients with narrow-angle glaucoma or untreated open-angle glaucoma.
• Contraindicated in individuals with severe high blood pressure, heart disease, or recent heart attack.
• Avoid using in patients with an overactive thyroid, diabetes, or kidney disease.
• Not suitable for individuals with severe nasal congestion due to nasal injury, surgery, or deformity.
• Should not be used during pregnancy or while breastfeeding.
• Avoid using in children under 6 years of age.
• Do not use if you have a nasal infection or untreated bacterial/viral/fungal infection.
• Contraindicated in patients with a history of nasal surgery or recent nasal procedures.

The side effects of Ephedrine, Naphazoline, and Fluprednisolone Spray may include:

• Increased heart rate
• Palpitations
• Restlessness or insomnia
• Anxiety or nervousness
• Elevated blood pressure
• Nasal irritation or dryness
• Throat irritation or dryness
• Sneezing
• Headache
• Nausea or upset stomach
• Nasal congestion or stuffiness
• Allergic reactions (rare)
• Eye discomfort or temporary blurred vision

Following are the precautions and warnings for Ephedrine, Naphazoline, Fluprednisolone Spray:

• Do not use this medication if you have untreated high blood pressure, heart disease, narrow-angle glaucoma, or overactive thyroid.
• Avoid using the spray if you have recently had nasal surgery or an injury/surgery to your nose.
• This medication may cause serious side effects, including increased blood pressure, rapid heartbeat, and nervousness. Seek medical attention if these occur.
• Ephedrine may be habit-forming; use it only as prescribed and do not share it with others.
• Naphazoline can cause a rebound effect, leading to increased nasal congestion; do not use it for longer than the recommended period.
• Fluprednisolone can suppress your immune system, making it harder for your body to fight infections. Avoid contact with people who are sick.
• Inform your doctor if you have any allergies, diabetes, or liver disease before using this spray.
• The long-term use of this medication is not recommended; follow the prescribed duration of treatment.

Following are the drug interactions for Ephedrine, Naphazoline, and Fluprednisolone Spray:

• Ephedrine may interact with other stimulants or medications for blood pressure, increasing the risk of hypertension and heart-related issues.
• Naphazoline, when used with other nasal decongestants or certain antidepressants, can elevate blood pressure and cause cardiovascular side effects.
• Fluprednisolone can reduce the effectiveness of live vaccines and increase the risk of infection when combined with immunosuppressants.
• Antifungal medications and certain antibiotics may interact with fluprednisolone, affecting its metabolism.
• The spray may increase the risk of bleeding when used with anticoagulants or antiplatelet drugs.
• Caution is advised with diabetes medications, as fluprednisolone can elevate blood glucose levels.
• Combining with diuretics may increase the risk of electrolyte imbalances and dehydration.
• Avoid using other corticosteroids simultaneously without medical advice.

Following are the food interactions for Ephedrine, Naphazoline, and Fluprednisolone Spray:

• Consuming foods and beverages containing caffeine (coffee, tea, colas, chocolate) while using Ephedrine can increase nervousness, rapid heartbeat, and insomnia.
• Grapefruit juice should be avoided with Ephedrine as it may decrease the breakdown of the medication in the liver, leading to increased side effects.
• Naphazoline may cause dryness of the mouth, so it is advisable to avoid dry, spicy, or acidic foods that can irritate the throat.
• Alcohol should be limited or avoided as it can increase the risk of gastrointestinal bleeding when taken with Fluprednisolone.
• Consuming high-sodium foods should be minimized, as Fluprednisolone can cause sodium retention, leading to swelling and increased blood pressure.
• Foods rich in vitamin C, such as citrus fruits and broccoli, may enhance the absorption of Fluprednisolone.
• Dairy products like milk and yogurt can help reduce stomach irritation if Fluprednisolone is causing stomach upset.
• A balanced diet with adequate protein and calcium is essential to minimize bone density loss, which can be a long-term side effect of Fluprednisolone use.

Storage and disposal of Ephedrine, Naphazoline, and Fluprednisolone Spray require careful attention to ensure safety and environmental responsibility. Store these medications in a cool, dry place, away from sunlight and moisture, maintaining room temperature. Keep them in their original containers, tightly sealed to prevent contamination. Avoid bathroom storage or placing them near heat sources like stoves or radiators, as temperature fluctuations can impact their effectiveness. Regularly check the expiration dates, and if the medication is expired or no longer needed, do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Additionally, keep all medications securely stored, out of children's reach, to prevent accidental ingestion.

Following are the quick tips for Ephedrine, Naphazoline, Fluprednisolone:

• Consult a healthcare professional before use, especially if you have pre-existing medical conditions.
• Follow the recommended dosage instructions provided by your doctor or pharmacist.
• Avoid prolonged use without medical supervision.
• Do not share medications with others, even if they have similar symptoms.
• Store the medications in a cool, dry place, away from direct sunlight.
• Dispose of expired or unused medication properly.
• Inform your doctor about any other medications you are taking to avoid potential interactions.
• In case of any adverse reactions, seek medical attention immediately.