DEMENTIO SYP

Galantamine HBr Syrup/Suspension works by inhibiting the action of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine in the brain. By blocking this enzyme, galantamine increases the levels of acetylcholine, a neurotransmitter involved in memory, cognition, and learning. This mechanism is crucial for treating conditions where acetylcholine levels are reduced, such as Alzheimer's disease. Galantamine selectively binds to acetylcholine receptors, enhancing cholinergic function and improving cognitive performance, particularly in individuals with cognitive impairments.

Galantamine HBr

Acetylcholinesterase inhibitor.

Suspension

The following are the uses of Galantamine HBr Syrup/Suspension:

• Used for enhancing cognitive function in mild to moderate Alzheimer's disease.
• Used for improving memory, attention, and overall cognitive performance.
• Used to treat symptoms of vascular dementia and age-related cognitive decline.
• Used to enhance learning abilities and neural plasticity.
• Used for its cholinergic effects, boosting the brain's acetylcholine levels.
• Used as an adjunct to other dementia treatments for improved outcomes.
• Used to delay the progression of cognitive impairment.

In the case of an overdose of Galantamine HBr Syrup/Suspension, symptoms may include severe nausea, vomiting, diarrhea, abdominal pain, slow heart rate, low blood pressure, and seizures. Prompt medical attention is necessary, and the individual should be closely monitored for any signs of respiratory depression or cardiac abnormalities. Treatment involves supportive care and managing the symptoms to prevent further complications. It is crucial to seek medical assistance immediately if an overdose is suspected.

In the case of a missed dose of Galantamine HBr Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication.

To take Galantamine HBr Syrup/Suspension, shake the bottle well, measure the prescribed dose with the provided measuring device, and administer it orally, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Galantamine HBr Syrup/Suspension should not be taken:

• Avoid using if you have a known allergy or hypersensitivity to galantamine, other acetylcholinesterase inhibitors, or any of the inactive ingredients in the medication.
• Not suitable for individuals with certain gastrointestinal conditions, such as ulcerative colitis, as it can worsen symptoms.
• Contraindicated in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Should not be used in individuals with severe liver or kidney disease, as it can lead to increased side effects.
• Avoid using if you have a history of cardiovascular issues, such as recent heart attack or unstable cardiac arrhythmias.
• Not recommended for individuals with active asthma, as it may exacerbate respiratory symptoms.
• Do not use in patients with urinary obstruction or conditions that may cause urinary retention.
• Contraindicated in patients undergoing surgery with general anesthesia, as it may enhance the effects of muscle relaxants.
• Avoid using Galantamine HBr Syrup/Suspension if you have a known allergy to any anticholinergic medications.

The side effects of Galantamine HBr Syrup/Suspension may include:

• Nausea and vomiting
• Weight loss
• Diarrhea
• Dizziness
• Slow heart rate
• Muscle weakness
• Increased gastric acid secretion
• Abdominal pain

Following are the precautions and warnings for Galantamine HBr Syrup/Suspension:

• Do not start or stop taking this medication without consulting your doctor, as it is important to maintain a consistent level of the drug in your body.
• This medication may cause dizziness or drowsiness, so caution should be exercised when performing tasks requiring alertness, such as driving or operating machinery.
• Patients with a history of gastrointestinal disorders, such as ulcers or reflux disease, should use this medication with caution as it may exacerbate these conditions.
• Galantamine HBr can affect heart rhythm; patients with a history of heart disease or arrhythmias should be closely monitored while taking this medication.
• Regular monitoring of kidney and liver function is recommended, especially in patients with pre-existing kidney or liver problems.
• Elderly patients may be more sensitive to the effects of this medication, so dosage adjustments might be necessary.
• Inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Galantamine HBr Syrup/Suspension:

• Concomitant use with other cholinesterase inhibitors like donepezil or rivastigmine may result in increased cholinergic effects and potential toxicity.
• Galantamine can potentiate the effects of neuromuscular blocking agents, leading to prolonged muscle relaxation during anesthesia.
• It may enhance the effects of anticholinergic drugs, causing increased heart rate and reduced gastrointestinal motility.
• The syrup's alcohol content may interact with metronidazole or disulfiram, causing unpleasant reactions.
• Caution with medications metabolized by CYP2D6 and CYP3A4 enzymes, as galantamine may alter their metabolism.
• Can increase gastrointestinal side effects when taken with nonsteroidal anti-inflammatory drugs (NSAIDs).
• May reduce the effectiveness of medications used for urinary bladder control.

Following are the food interactions for Galantamine HBr Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the drug's bioavailability, leading to potential side effects.
• Alcohol intake should be minimized as it can enhance the sedative effects of the medication, causing increased drowsiness and dizziness.
• Consuming high-fat meals before taking Galantamine HBr may slightly delay the absorption of the medicine.
• Avoid consuming large amounts of acidic foods or beverages, as they can potentially irritate the stomach and affect the medication's absorption.
• Some herbal supplements, like St. John's Wort, may interact with Galantamine, so consult a healthcare professional before taking any herbal remedies.
• Ensure adequate fluid intake to maintain hydration, especially if the medication causes dry mouth as a side effect.
• Avoid consuming excessive amounts of sugar-rich foods, as Galantamine HBr syrup already contains sugar, and excess sugar intake should be monitored.
• There are no specific food restrictions, but maintaining a balanced diet is advisable to support overall health.

Galantamine HBr Syrup/Suspension should be stored in a controlled environment, maintaining a cool and dry atmosphere at room temperature, typically between 20-25°C (68-77°F). Protect the medication from direct exposure to sunlight and moisture, and ensure it is tightly sealed within its original packaging to prevent contamination. Avoid storing it in areas prone to temperature fluctuations, such as bathrooms, kitchens, or near heat sources, as this can compromise the medicine's integrity. Adhere to proper disposal practices by consulting a pharmacist or healthcare professional to ensure safe and environmentally friendly disposal, avoiding flushing or pouring the medication down the drain. Always keep medications securely stored and out of the reach of children to prevent accidental consumption.

Following are the quick tips for Galantamine HBr Syrup/Suspension:

• Store the syrup in a cool, dry place, away from direct sunlight and moisture.
• Check the expiration date before use and discard if expired.
• Administer the prescribed dose accurately using the measuring device provided.
• Rinse your mouth after taking the syrup to ensure complete consumption.
• Avoid mixing the syrup with other medications without medical advice.
• Inform your doctor about any allergies or medical conditions before starting this medication.
• Contact your healthcare provider if you experience any unusual symptoms or have concerns.