DEPRISIN JOHN'S WORT TAB

St. John's Wort Extract, derived from the plant Hypericum perforatum, primarily exerts its effects through multiple biochemical pathways. The main constituents, hypericin and hyperforin, are believed to contribute to its mechanism of action. Hypericin has been found to act as a reuptake inhibitor for certain neurotransmitters in the brain, primarily serotonin, norepinephrine, and dopamine, increasing their availability in the synaptic cleft and enhancing neurotransmission. This action may contribute to its antidepressant effects. Additionally, St. John's Wort Extract may interact with various receptors, including adenosine, GABA, and glutamate receptors, which can influence mood and emotional responses. Hyperforin, another active component, is thought to modulate the activity of ion channels and may possess anti-inflammatory properties. This extract also exhibits antioxidant properties, potentially protecting cells from oxidative stress. By interacting with these diverse biological pathways, St. John's Wort Extract may contribute to its therapeutic effects, particularly in the treatment of mild to moderate depression and mood disorders.

Antidepressant

Tablet

The following are the uses of ST. JOHN'S WORT EXTRACT Tablet:

• Used for treating mild to moderate depression and improving mood.
• Used for reducing symptoms of anxiety and promoting emotional well-being.
• Used for relieving premenstrual symptoms, including mood swings and irritability.
• Used for its potential to alleviate sleep disturbances and improve sleep quality.
• Used for managing symptoms of menopause, such as mood changes and hot flashes.
• Used for supporting wound healing and soothing skin irritations.
• Used for its antioxidant properties, which may contribute to overall health.
• Used as a natural remedy to enhance emotional and mental well-being.

In the case of an overdose of St. John's Wort Extract Tablets, it is important to remain calm and take immediate action. Contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the amount ingested and individual health factors. Common symptoms of overdose may include gastrointestinal issues, increased sensitivity to sunlight, and fatigue. Prompt medical advice is crucial to ensure appropriate treatment and prevent potential complications.

In the case of a missed dose of St. John's Wort Extract Tablet, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting an alarm or using a pill organizer to help you stay on track with your medication regimen.

To take ST. JOHN'S WORT EXTRACT Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when ST. JOHN'S WORT EXTRACT Tablet should not be used:

• Should not be used in individuals with a known sensitivity or allergy to St. John's Wort or any of the tablet's ingredients.
• Contraindicated in patients who are taking certain medications, such as antidepressants, blood thinners, and medications for HIV/AIDS, as it can interfere with their effectiveness.
• Not recommended for individuals with bipolar disorder, as it may trigger manic episodes.
• Should not be used in patients with liver disease or impaired liver function.
• Not suitable for individuals who are scheduled for surgery, as it may increase bleeding risk.
• Contraindicated in women who are pregnant or breastfeeding, as its safety is not fully established.
• Avoid using St. John's Wort extract in children and adolescents, as its effects on this age group are not well studied.
• Do not use if you have a history of photosensitivity or if you are currently taking medications that make you sensitive to sunlight.

The side effects of ST. JOHN'S WORT EXTRACT Tablet may include:

• Increased sensitivity to sunlight, leading to sunburns.
• Dizziness and confusion.
• Dry mouth and excessive thirst.
• Fatigue and drowsiness.
• Headaches and migraines.
• Upset stomach, including nausea and diarrhea.
• Allergic reactions, such as skin rash and itching.
• In rare cases, it may cause mania or hypomania in individuals with bipolar disorder.

Following are the precautions and warnings for ST. JOHN'S WORT EXTRACT Tablet:

• Avoid if you have a known allergy or sensitivity to St. John's Wort or any of its constituents.
• Consult a healthcare professional if you have a history of psychiatric disorders, as St. John's Wort may exacerbate these conditions.
• Exercise caution when combining with prescription medications, especially antidepressants, as it may interact and alter their effectiveness.
• Be cautious if you are taking medications for other conditions, as St. John's Wort can affect the metabolism of various drugs.
• Avoid excessive exposure to sunlight or UV rays while taking St. John's Wort, as it may increase photosensitivity.
• Discontinue use and seek medical attention if you experience any adverse reactions, such as severe skin rash, anxiety, or gastrointestinal issues.
• Keep out of reach of children and pets. Store in a cool, dry place away from direct sunlight.

Following are the drug interactions for ST. JOHN'S WORT EXTRACT Tablet:

• Inhibits the activity of cytochrome P450 enzymes, leading to decreased levels of medications metabolized by these enzymes, such as warfarin, birth control pills, and certain antidepressants.
• May reduce the effectiveness of immunosuppressants like cyclosporine and tacrolimus.
• Interaction with antidepressants (e.g., SSRIs, SNRIs) can increase the risk of serotonin syndrome, a potentially serious condition with symptoms like agitation, tremors, and increased heart rate.
• Can reduce the plasma levels of certain antiretroviral medications used to treat HIV/AIDS, potentially decreasing their effectiveness.
• May decrease the concentration of digoxin, a heart medication, requiring close monitoring.
• May interact with other medications metabolized by CYP3A4 enzymes, including statins, calcium channel blockers, and some anti-seizure medications.
• Concomitant use with other herbal supplements or medications that affect serotonin levels should be closely monitored.

Following are the food interactions for ST. JOHN'S WORT EXTRACT Tablet:

• Avoid excessive consumption of tyramine-rich foods such as aged cheeses, cured meats, and certain types of beer. Tyramine can interact with St. John's Wort and lead to elevated blood pressure.
• Limit or avoid alcohol intake as it can increase the sedative effects and potentially cause excessive drowsiness.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the metabolism of St. John's Wort, leading to increased levels in the body.
• Be cautious with high-fat meals as they might affect the absorption of St. John's Wort, possibly requiring a higher dose for effectiveness.
• Chocolate, particularly dark chocolate, contains compounds that can interact with St. John's Wort, potentially affecting its efficacy and increasing side effects.
• Caffeine-rich beverages like coffee and energy drinks may amplify the stimulating effects of St. John's Wort, leading to restlessness and insomnia.
• Certain herbal teas, especially those containing valerian or kava, should be used cautiously as they can enhance the sedative properties of St. John's Wort.
• Always consult a healthcare professional or pharmacist for personalized advice, as they can provide specific dietary recommendations based on your health status.

St. John's Wort Extract Tablets should be stored in a cool, dry location, preferably at room temperature, away from direct sunlight and moisture. The tablets should be kept in their original packaging, ensuring the container is tightly sealed to maintain their integrity and prevent contamination. It's crucial not to expose the tablets to extreme temperatures, so avoid storing them in hot or humid environments, including bathrooms or kitchens. Proper disposal is essential; do not flush or pour the tablets down the drain. Consult your pharmacist for guidance on appropriate disposal methods. Keep the tablets out of children's reach to prevent accidental consumption. Always be mindful of the expiration date, and dispose of any outdated medication responsibly.

Following are the quick tips for St. John's Wort Extract Tablet:

• Consult a healthcare professional before use, especially if you have a medical condition or are taking other medications.
• Take the tablet as directed on the label or as prescribed by your healthcare provider.
• Swallow the tablet whole with a full glass of water, preferably with a meal.
• Avoid taking with other herbal supplements without medical advice.
• Do not exceed the recommended dosage, as it may lead to increased side effects.
• Store in a cool, dry place, away from direct sunlight and moisture.
• Keep out of reach of children and pets to prevent accidental consumption.