DEPROGESIC TAB

Paracetamol, also known as acetaminophen, works primarily by inhibiting the synthesis of prostaglandins, which are involved in pain and inflammation signaling. It acts on the central nervous system to increase the pain threshold, thereby reducing the perception of pain. Dextropropoxyphene, on the other hand, is an opioid analgesic that binds to opioid receptors in the brain and spinal cord, altering the body's perception of pain. It enhances the effects of paracetamol by further blocking pain signals and providing additional analgesia. The combination of these two drugs offers a synergistic effect, providing more effective pain relief than either drug alone.

Analgesic, Opioid

Tablet

The following are the uses of Paracetamol, Dextropropoxyphene Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, backaches, and period pain.
• Used for reducing fever and managing symptoms of cold and flu.
• Used for easing discomfort in conditions like arthritis and muscle strains.
• Used for providing pain relief after minor surgeries or medical procedures.
• Used for treating pain and fever associated with various infections.
• Used for managing pain in chronic conditions under medical supervision.
• Used for symptomatic relief in combination with other medications.

In the case of an overdose of Paracetamol and Dextropropoxyphene Tablets, individuals may experience severe symptoms such as liver damage, gastrointestinal issues, and central nervous system effects. The severity of the overdose can range from mild to life-threatening, depending on the amount ingested. Prompt medical intervention is necessary to manage the overdose, which may include administering specific antidotes and providing supportive care to minimize the potential harm caused by the excessive medication intake.

In the case of a missed dose of Paracetamol, it is generally recommended to take the dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Dextropropoxyphene, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing intervals.

To take the Paracetamol, Dextropropoxyphene Tablet, place the tablet on your tongue and swallow it with a glass of water, ensuring you follow the prescribed dosage as instructed by your healthcare provider.

Here are the conditions or situations when Paracetamol, Dextropropoxyphene Tablet should not be taken:

• Avoid if you have a known allergy or hypersensitivity to paracetamol, dextropropoxyphene, or any of the tablet's components.
• Do not use if you have severe respiratory depression or asthma.
• Contraindicated in individuals with acute alcohol intoxication.
• Should not be used in patients with severe liver or kidney impairment.
• Not suitable for individuals with a history of head injury, increased intracranial pressure, or seizure disorders.
• Avoid using this medication if you have gastrointestinal obstruction or chronic constipation.
• Do not administer to patients with a known or suspected paralytic ileus.
• Contraindicated during pregnancy, especially in the third trimester, due to potential risks to the fetus.
• Should not be used by breastfeeding mothers as it can pass into breast milk.
• Not recommended for children below a certain age (age limit varies by country and medical guidelines).
• Avoid if you have a history of drug abuse or dependence.

The side effects of Paracetamol and Dextropropoxyphene Tablet may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Drowsiness or fatigue
• Constipation
• Dry mouth
• Skin rash or itching
• Difficulty in urination
• Respiratory depression (slowed breathing)

Following are the precautions and warnings for Paracetamol, Dextropropoxyphene Tablet:

• Do not exceed the recommended dosage, as excessive use can lead to liver damage.
• This medication should be used with caution in patients with liver or kidney disease. Regular monitoring of liver and kidney function is advised.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of liver damage.
• Do not use this medication if you have a known allergy to Paracetamol or Dextropropoxyphene.
• Patients with respiratory problems, such as asthma or chronic obstructive pulmonary disease (COPD), should use this medication with caution, as Dextropropoxyphene may cause breathing difficulties.
• Elderly patients may be more sensitive to the side effects of this medication, especially dizziness and drowsiness.
• This medication may impair your ability to drive or operate machinery, so avoid such activities until you know how the medication affects you.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Paracetamol and Dextropropoxyphene may have potential risks for the fetus or infant.

Following are the drug interactions for Paracetamol and Dextropropoxyphene Tablet:

• Alcohol and other central nervous system depressants (e.g., benzodiazepines, opioids) can increase the risk of respiratory depression and sedation when used with this combination.
• Anticoagulants like warfarin may have their effects altered, potentially requiring dose adjustments.
• Dextropropoxyphene can inhibit the metabolism of certain antidepressants (e.g., SSRIs, tricyclic antidepressants), leading to increased levels and side effects.
• Paracetamol may enhance the risk of bleeding when taken with anticoagulants or antiplatelet drugs.
• The effectiveness of some anticonvulsant medications may be reduced by dextropropoxyphene.
• Drugs that induce or inhibit liver enzymes (e.g., rifampicin, ketoconazole) can affect the metabolism of dextropropoxyphene and paracetamol.
• Concomitant use with other opioids or CNS depressants may result in additive respiratory depression and sedation.

Following are the food interactions for Paracetamol, Dextropropoxyphene Tablet:

• Alcohol should be avoided as it can increase the risk of liver damage, especially with prolonged use of Paracetamol.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Dextropropoxyphene, potentially increasing its levels in the body.
• Caffeine-containing products like coffee, tea, and energy drinks may interact with Paracetamol, altering its pain-relieving effects.
• Fatty foods can slightly delay the absorption of Paracetamol, but this effect is generally not clinically significant.
• Avoid consuming large amounts of foods containing tyramine (aged cheeses, cured meats, fermented foods) while taking Dextropropoxyphene, as it may lead to a spike in blood pressure.
• Avoid eating heavy meals before or after taking the tablet to ensure consistent absorption and effectiveness.
• There are no specific food restrictions for Paracetamol, but maintaining a balanced diet is generally recommended.
• Always consult your healthcare provider for personalized advice regarding food interactions with your medication.

Paracetamol and Dextropropoxyphene tablets should be stored in a secure, dry location, preferably at room temperature, away from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or near heat-emitting appliances to protect against temperature fluctuations. Always adhere to local regulations and guidelines when disposing of unused or expired tablets; do not flush them down the toilet or pour them into drains. Consult your pharmacist or local waste management authorities for appropriate disposal methods, and ensure that the medication is kept out of the reach of children to prevent accidental consumption. Proper storage and disposal are crucial for maintaining the efficacy of the medication and ensuring safety.

Following are the quick tips for Paracetamol, Dextropropoxyphene Tablet:

• Consult a doctor for the correct dosage and duration of medication.
• Swallow the tablet whole, do not crush or chew.
• Take with a full glass of water for better absorption.
• Avoid alcohol consumption while on this medication.
• Inform your doctor if you have liver or kidney issues before taking this medicine.
• Do not drive or operate machinery if you feel drowsy after taking the tablet.
• Store in a cool, dry place, away from direct sunlight.