Dermaan (30/500mg) 100 Tablets

Paracetamol, also known as acetaminophen, works by inhibiting the synthesis of prostaglandins, which are involved in pain and inflammation pathways. It primarily acts on the central nervous system to reduce pain signals and increase the pain threshold. On the other hand, codeine, an opioid analgesic, binds to opioid receptors in the brain and spinal cord, which modifies the perception of pain and enhances the effects of paracetamol. Codeine also suppresses the cough reflex by acting on the cough center in the medulla oblongata. When combined in a tablet, these two drugs provide synergistic pain relief, with paracetamol addressing peripheral pain mechanisms and codeine targeting central pain pathways.

Analgesic, Opioid

Tablet

The following are the uses of Paracetamol, Codeine Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, and post-vaccination fever.
• Used to reduce fever and manage discomfort associated with colds and flu.
• Effective in easing pain and inflammation related to conditions like osteoarthritis.
• Helps manage acute pain after injuries or surgical procedures.
• Provides relief from menstrual cramps and associated pain.
• Can be used to alleviate pain in patients with chronic conditions under medical supervision.
• Offers a balanced approach to pain management by combining paracetamol and codeine's effects.

In the case of an overdose of Paracetamol and Codeine Tablets, individuals may experience a range of symptoms. These can include gastrointestinal issues such as nausea, vomiting, and abdominal pain. Additionally, there could be central nervous system effects like drowsiness, confusion, and even loss of consciousness. It is important to note that the severity of symptoms may vary depending on the amount ingested and individual factors. Prompt medical intervention is necessary to manage potential complications.

In the case of a missed dose of Paracetamol and Codeine tablets, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is important to maintain a consistent dosing routine for the best therapeutic effect.

To take the Paracetamol, Codeine Tablet, place the tablet on your tongue and swallow it with a glass of water, ensuring you follow the prescribed dosage instructions provided by your healthcare professional, typically taken every 4 to 6 hours, or as directed by your doctor.

Here are the conditions and situations when Paracetamol, Codeine Tablet should not be used:

• Avoid using if you have a known allergy or hypersensitivity to paracetamol, codeine, or any other ingredients in the tablet formulation.
• Do not take if you have severe breathing problems or asthma, as codeine can worsen respiratory conditions.
• Contraindicated in individuals with a history of respiratory depression or severe breathing disorders.
• Should not be used in patients with acute abdominal conditions or severe gastrointestinal issues.
• Not suitable for patients with a history of seizures or conditions that lower the seizure threshold.
• Avoid using if you have a head injury or increased intracranial pressure.
• Do not use in patients with severe liver impairment or acute liver disease.
• Contraindicated during breastfeeding, as codeine can pass into breast milk and affect the infant.
• Should not be used in children below a certain age (age limit varies by country and medical guidelines).
• Avoid using if you have a history of drug abuse or are currently taking monoamine oxidase inhibitor (MAOI) medications.
• Not recommended for individuals with certain metabolic disorders, such as porphyria.
• Do not use in patients who have recently undergone surgery involving the biliary tract.

The side effects of Paracetamol, Codeine Tablet may include:

• Drowsiness
• Constipation
• Nausea and vomiting
• Dry mouth
• Dizziness
• Itching
• Difficulty urinating
• Respiratory depression (slowed or difficult breathing)

Following are the precautions and warnings:

• Do not exceed the recommended dosage of Paracetamol, Codeine Tablet as it may lead to liver damage, especially in patients with existing liver conditions.
• This medication contains codeine, an opioid, which can be habit-forming. It should be used with caution and only as directed by a healthcare professional.
• Patients with respiratory conditions such as asthma or COPD should exercise caution as codeine can cause respiratory depression.
• Not recommended for use in children below a certain age (consult a pediatrician for age-specific guidelines).
• Avoid alcohol consumption while taking this medication as it may enhance the sedative effects of codeine.
• Patients with a history of gastrointestinal issues like stomach ulcers or blockages should use it with caution as codeine can affect gastrointestinal motility.
• Paracetamol may interact with other medications, so inform your doctor about all the medicines you are taking to prevent potential drug interactions.
• Seek immediate medical attention if you experience symptoms of an allergic reaction, such as rash, itching, swelling, or difficulty breathing.

Following are the drug interactions for Paracetamol, Codeine Tablet:

• Alcohol consumption with this medication may increase the risk of liver damage and enhance the sedative effects of codeine.
• Other central nervous system depressants, such as benzodiazepines or other opioids, can lead to respiratory depression and profound sedation when used together.
• Paracetamol may interact with anticoagulants like warfarin, requiring close monitoring of INR (International Normalized Ratio).
• Codeine can interact with certain medications like SSRIs, SNRIs, and triptans, potentially leading to serotonin syndrome.
• Drugs that inhibit CYP450 enzymes may increase codeine levels, enhancing its effects and side effects.
• The effectiveness of codeine may be reduced by medications that induce CYP450 enzymes, leading to decreased pain relief.
• Paracetamol can potentially increase the risk of liver damage when used with other hepatotoxic drugs.

Following are the food interactions for Paracetamol, Codeine Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the metabolism of Codeine, reducing its effectiveness.
• Alcohol consumption should be limited or avoided as it can enhance the sedative effects of Codeine, increasing the risk of dizziness and drowsiness.
• Avoid eating large meals just before or after taking the tablet, as it may affect the absorption of the medication.
• Caffeine-containing beverages should be limited as they can interfere with the pain-relieving effects of Codeine.
• Foods high in fat may delay the absorption of the medication, affecting its onset of action.
• Avoid eating spicy foods as they can irritate the stomach and potentially affect the absorption of the tablet.
• Consuming a light meal or snack after taking the tablet can help reduce the risk of stomach irritation.

Paracetamol, Codeine Tablets should be stored in a secure and dry location, preferably in their original container, away from direct sunlight, heat, and moisture. It is crucial to keep the medication out of reach of children and pets to prevent accidental consumption. Always check the expiration date before taking the tablets, and do not use if the medication is past its expiry. Disposal of unused or expired tablets should be done responsibly; do not flush them down the toilet or discard them into the trash. Contact your pharmacist or local waste management authorities for guidance on proper disposal methods to ensure environmental safety. It is essential to handle and store this medication with care to maintain its effectiveness and prevent any potential harm.

Following are the quick tips for Paracetamol, Codeine Tablet:

• Consult a doctor or pharmacist for personalized advice on dosage and duration.
• Swallow the tablet whole, do not crush or chew.
• Ensure you are not allergic to any ingredients before taking the tablet.
• Avoid alcohol consumption while using this medication.
• Inform your doctor if you have liver or kidney problems.
• Do not drive or operate machinery if the tablet causes drowsiness.
• Store in a cool, dry place away from direct sunlight.