Dermistat (2%) 10g Cream

Miconazole cream, a topical antifungal medication, exerts its antifungal effect primarily by disrupting the synthesis of ergosterol, a crucial component of fungal cell membranes. It selectively binds to fungal cytochrome P450 enzymes, specifically targeting the enzyme lanosterol 14-alpha-demethylase, which is essential for converting lanosterol to ergosterol. By inhibiting this enzyme, miconazole blocks the production of ergosterol, leading to the accumulation of toxic 14-alpha-methyl sterols. This disruption in the fungal cell membrane integrity compromises its structure and function, ultimately resulting in fungal cell death.

Antifungal

Cream

The following are the uses of Miconazole Cream:

• Used for treating fungal skin infections such as athlete's foot, jock itch, and ringworm.
• Used for relieving itching, redness, and discomfort associated with fungal infections.
• Used for inhibiting the growth and spread of fungi on the skin.
• Used for preventing fungal infections, especially in areas prone to moisture and warmth.
• Used for maintaining skin health and integrity during fungal infection treatment.
• Used for soothing and healing skin inflammation caused by fungal overgrowth.
• Used for addressing fungal infections that may occur in skin folds and creases.
• Used for supporting the recovery of skin's natural barrier function.

In the case of an overdose of Miconazole Cream, it is important to recognize that this topical medication is generally safe when used as directed. However, if a large amount is accidentally ingested or applied excessively, it may lead to increased skin irritation or adverse effects. In such instances, promptly contact a healthcare professional or a poison control center for guidance. They will provide specific instructions and support to manage any potential risks associated with the overdose.

In the case of a missed dose of Miconazole Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. It is generally safe to miss a dose occasionally, but if you frequently miss doses, the treatment may not be as effective. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To use Miconazole Cream, clean and dry the affected area, then apply a thin layer of the cream to the skin, gently rubbing it in, usually twice a day or as directed by your healthcare provider.

Following are the conditions/situations to avoid when using Miconazole Cream:

• Do not use if you have a known allergy or sensitivity to Miconazole or any of the cream's ingredients.
• Avoid using Miconazole Cream if you are taking other medications without consulting your doctor, as it may interact with certain drugs.
• Not suitable for individuals with a history of liver problems or impaired liver function.
• Should not be used on children without medical advice.
• Avoid using on open wounds, burns, or severely broken skin.
• Do not use in the eyes or inside the ears, nose, or mouth.
• Do not continue use if you experience severe irritation, redness, or swelling at the application site.

The side effects of Miconazole Cream may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Swelling or inflammation
• Dryness of the skin
• Blistering or peeling
• Allergic reactions (such as hives, difficulty breathing)

Following are the precautions and warnings for Miconazole Cream:

• Avoid using this cream if you have a known allergy to miconazole or any other antifungal medications.
• It is important to complete the full course of treatment, even if symptoms improve before completion.
• Do not apply the cream to broken or severely damaged skin, and avoid contact with eyes and mucous membranes.
• Wash your hands thoroughly before and after applying the cream to avoid spreading the infection.
• Avoid covering the treated area with bandages or tight clothing, as this may increase the risk of side effects.
• If symptoms persist or worsen, or if you experience any signs of an allergic reaction, discontinue use and consult a healthcare professional.
• Keep the cream out of reach of children and pets. Store it at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Miconazole Cream:

• Other topical antifungals, such as clotrimazole, may lead to reduced effectiveness of either medication when used together.
• Avoid using with other topical medications without consulting a healthcare professional, as it may alter the skin's absorption.
• Miconazole may increase the effects of oral anticoagulants like warfarin, requiring close monitoring of blood clotting times.
• Topical steroids, when used with miconazole, may increase the risk of skin atrophy and other side effects.
• Applying miconazole cream under occlusive dressings can enhance its absorption and potentially increase systemic effects.
• Anticonvulsant medications (e.g., phenytoin) may have their blood levels affected by miconazole, requiring monitoring and possible dosage adjustments.
• Some oral hypoglycemic agents used in diabetes may interact with miconazole, necessitating close monitoring of blood glucose levels.

Following are the food interactions for Miconazole Cream:

• Avoid applying Miconazole cream on areas with food residue, especially in the case of oral Miconazole, as it can be accidentally ingested.
• There is no specific food interaction with Miconazole cream, as it is a topical application and has minimal systemic absorption.
• Unlike oral medications, the risk of drug-food interactions is significantly lower with topical treatments like Miconazole cream.
• Miconazole cream can be used safely without worrying about dietary restrictions.
• However, always ensure the treated area is clean and dry before application.
• Maintain good hygiene to maximize the effectiveness of the treatment.
• Focus on a balanced diet to support overall skin health.
• Consult a healthcare provider if you have concerns about specific food interactions or dietary advice during treatment.

Miconazole Cream should be stored in a cool and dry area, preferably at room temperature, ensuring it is kept away from direct sunlight, moisture, and heat sources like ovens or radiators. Maintain the cream's integrity by storing it in its original container with the lid tightly secured. Regularly check the expiration date, and when disposing of the cream, avoid flushing it down the toilet or pouring it into drains. Consult your pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Miconazole Cream:

• Wash and dry the affected area before applying the cream.
• Apply a thin layer of cream to the affected skin and surrounding areas.
• Gently rub the cream into the skin until it is completely absorbed.
• Wash your hands after application, unless you are treating the hands.
• Avoid covering the treated area with tight clothing or bandages to allow the skin to breathe.
• Continue using the cream for the full prescribed duration, even if symptoms improve.
• Store the cream at room temperature, away from direct sunlight and moisture.