DESFERAL 0.5G INJ

Deferoxamine injection works by acting as a chelating agent, specifically designed to bind with excess iron in the body. It forms stable complexes with ferric (Fe3+) ions, facilitating their excretion through the kidneys. This mechanism helps remove excess iron from the body, which is particularly important in conditions such as acute iron intoxication or chronic iron overload. By chelating and removing iron, deferoxamine prevents the formation of harmful free radicals and reduces the risk of tissue damage and organ dysfunction associated with iron overload.

deferoxamine

chelating agent.

Injection

The following are the uses of deferoxamine Injection:

• Used for treating acute iron poisoning, helping to remove excess iron from the body.
• Used for managing chronic iron overload in conditions like thalassemia and other blood disorders.
• Used for reducing the risk of heart complications in patients with chronic iron overload.
• Used for controlling iron levels in patients with certain types of anemia.
• Used for improving organ function in cases of iron-induced organ damage.
• Used for preventing and treating iron-related complications in dialysis patients.
• Used for supporting chelation therapy in heavy metal poisoning.

In the case of an overdose of deferoxamine injection, immediate medical intervention is necessary. Symptoms may include severe hypotension, cardiac arrhythmias, and respiratory distress. Treatment should focus on stabilizing vital signs, closely monitoring cardiac function, and providing respiratory support. The healthcare team should promptly initiate measures to prevent further iron chelation and manage any complications arising from the overdose. Prompt recognition and management are crucial to ensuring the best possible outcome.

In the case of a missed dose of deferoxamine injection, it is important to administer the missed dose as soon as possible. If it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. However, do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule and ensure the best treatment outcome.

To administer deferoxamine injection, prepare the medication by drawing the prescribed dose into a syringe, then inject it slowly into the vein or as directed by your healthcare professional, ensuring the needle is properly inserted into the vein for intravenous administration.

Following are the conditions when deferoxamine injection should be avoided:

• Must not be used in patients with a known allergy or hypersensitivity to deferoxamine or any of its excipients.
• Not suitable for patients with acute hepatitis or chronic active hepatitis.
• Avoid using in patients with a history of anaphylactic or anaphylactoid reactions to other iron chelating agents.
• Do not administer to patients with advanced liver disease or severe hepatic impairment.
• Contraindicated in patients with severe hypotension or shock.
• Not recommended for patients with severe cardiac disease or unstable cardiovascular status.
• Avoid use in patients with severe kidney disease or those on dialysis, as dosage adjustments are necessary.
• Should not be used in patients with a history of pulmonary disease or severe respiratory conditions.

The side effects of deferoxamine Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Hearing loss or ringing in the ears (tinnitus)
• Joint pain
• Low blood pressure
• Fever
• Allergic reactions

Following are the precautions and warnings for deferoxamine injection:

• Not recommended for patients with known hypersensitivity or allergy to deferoxamine or any of its excipients.
• Requires close medical supervision due to potential serious side effects, including hypotension, allergic reactions, and hearing/vision disturbances.
• Caution is advised in patients with pre-existing kidney or liver disease, as deferoxamine is primarily eliminated via these organs.
• Regular monitoring of liver and kidney function is necessary during prolonged treatment.
• May cause foetal harm; pregnant women should only use it if the potential benefits outweigh the risks.
• Not recommended for breastfeeding mothers as deferoxamine may pass into breast milk.
• Elderly patients may be more susceptible to side effects, requiring careful dose adjustment.
• Always administer under medical supervision; self-medication is not advised.

Following are the drug interactions for deferoxamine Injection:

• Concomitant use with other iron chelating agents like deferasirox may result in additive side effects and should be avoided.
• Deferoxamine can reduce the effectiveness of certain vaccines, so live virus vaccines should not be administered concurrently.
• Probenecid, a uricosuric agent, can decrease the renal excretion of iron complexes formed by deferoxamine, potentially increasing the risk of adverse effects.
• The antibiotic ciprofloxacin may interfere with the absorption of deferoxamine, reducing its effectiveness.
• Concurrent use of deferoxamine with aluminum-containing antacids may lead to increased aluminum absorption, which can be toxic.
• Theophylline, a bronchodilator, may have its clearance reduced by deferoxamine, potentially leading to elevated theophylline levels and increased side effects.
• Deferoxamine can increase the risk of bleeding when used with anticoagulants such as heparin or warfarin. Close monitoring is necessary.

Following are the food interactions for Deferoxamine Injection:

• Deferoxamine can decrease the absorption of oral iron supplements, so it's best to separate the timing of the injection and iron intake.
• Avoid alcohol consumption during treatment as it can increase the risk of side effects and may impair the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of certain medications, potentially altering the effects of Deferoxamine.
• High-iron foods like red meat, liver, and iron-fortified cereals should be consumed in moderation to maintain a balanced iron level in the body.
• Vitamin C-rich foods can enhance iron absorption, so consider including citrus fruits, bell peppers, and broccoli in your diet.
• Calcium-rich foods like dairy products may interfere with iron absorption, so ensure a balanced diet without excessive calcium intake.
• Avoid consuming large amounts of black or green tea, as they contain tannins that can reduce iron absorption.
• Always consult your healthcare provider for personalized dietary recommendations during Deferoxamine therapy.

The proper storage and disposal of deferoxamine injection are essential to maintain its effectiveness and safety. Store the injection in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F), ensuring it remains protected from light. Do not freeze the medication as it may affect its potency. Always check the expiration date on the vial or ampoule before use and discard if expired. When disposing of unused or expired medication, do not throw it into the regular trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure it is done in an environmentally friendly manner, keeping it out of the reach of children and pets.

Following are the quick tips for deferoxamine Injection:

• Deferoxamine injection should be administered by a healthcare professional.
• Ensure the injection is prepared and stored as directed by the pharmacist.
• The injection is typically given slowly into a vein over several hours.
• Avoid rapid or bolus injections to prevent side effects.
• Monitor vital signs during and after the infusion.
• Report any signs of allergic reaction or infusion-related complications immediately.
• Regularly check liver and kidney function during long-term treatment.