Desofam (0.15/0.03mg) 28 Tablets

Ethinylestradiol, a synthetic estrogen, primarily works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen. It inhibits the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which suppresses the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This suppression prevents ovulation by inhibiting the maturation and release of the egg from the ovary. Desogestrel, a progestin, exerts its effects by binding to progesterone receptors, particularly in the uterus and cervix. It causes changes in the cervical mucus, making it thicker and less penetrable by sperm, thereby inhibiting sperm penetration. Additionally, desogestrel inhibits the growth of the endometrium, making it less receptive to implantation, and alters the endometrial lining, reducing the likelihood of a fertilized egg implanting in the uterus. Together, these mechanisms contribute to the contraceptive effect of the combined oral contraceptive pill.

Ethinyloestradiol, Desogestrel

Oral contraceptive.

Tablet

The following are the uses of Ethinyloestradiol, Desogestrel Tablet:

• Used for preventing pregnancy and providing effective birth control.
• Used for regulating irregular menstrual cycles and reducing menstrual pain.
• Used for treating acne and improving skin conditions related to hormonal imbalances.
• Used for managing heavy menstrual bleeding and reducing the risk of anemia.
• Used for alleviating symptoms of premenstrual syndrome (PMS) and enhancing overall well-being.
• Used for endometriosis management, reducing associated pain and discomfort.
• Used for certain hormone-related conditions, offering relief from symptoms.
• Used for supporting hormonal balance and overall reproductive health.

In the case of an overdose of Ethinyloestradiol and Desogestrel Tablets, individuals may experience nausea, vomiting, breast tenderness, dizziness, and abdominal pain. The severity of symptoms can vary depending on the amount ingested. Promptly seeking medical advice is essential to manage potential complications. Medical professionals should be informed about the overdose to ensure appropriate treatment and monitoring, especially for severe cases.

In the case of a missed dose of Ethinyloestradiol and Desogestrel tablets, it is recommended to take the missed pill as soon as you remember, even if it means taking two pills in one day. However, if you remember too late and it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Ethinyloestradiol, Desogestrel Tablet, swallow one tablet daily, preferably at the same time each day, as directed by your healthcare provider, and it can be taken with or without food.

Here are the situations when Ethinyloestradiol, Desogestrel Tablet should not be used:

• Do not use if you have a known allergy or hypersensitivity to Ethinyloestradiol, Desogestrel, or any of the tablet's components.
• Contraindicated in individuals with a history of blood clots or thromboembolic disorders, such as deep vein thrombosis (DVT) or pulmonary embolism.
• Should not be used in women who are pregnant or suspect they might be pregnant.
• Contraindicated in individuals with a history of stroke or heart attack.
• Not suitable for individuals with severe high blood pressure (hypertension) or uncontrolled hypertension.
• Should not be used if you have a history of liver disease or if you currently have liver problems, including jaundice.
• Contraindicated in individuals with a history of breast cancer or any estrogen-dependent cancer.
• Do not use if you have a history of severe migraine headaches, especially if they are accompanied by aura.
• Not recommended for individuals with diabetes, especially if it is poorly controlled.
• Should not be used in individuals with a history of pancreatic disease or gallbladder disease.
• Contraindicated in women with severe circulatory disorders, such as sickle cell disease.
• Do not use if you have a history of certain types of skin disorders, such as severe itching or jaundice during a previous pregnancy.

The side effects of Ethinyloestradiol, Desogestrel Tablet may include:

• Nausea and vomiting
• Headaches or migraines
• Breast tenderness or enlargement
• Mood changes, including depression or irritability
• Abdominal pain or bloating
• Weight fluctuations
• Skin changes, such as acne or darkening of skin patches
• Increased blood pressure

Following are the precautions and warnings for Ethinyloestradiol, Desogestrel Tablet:

• This medication should not be used if you are pregnant or planning to become pregnant. It can cause serious harm to the unborn baby.
• Smoking while taking this medication significantly increases the risk of blood clots, especially in women over 35.
• Women with a history of blood clots, stroke, heart attack, or circulation problems should not use this medication as it increases the risk of further cardiovascular events.
• Individuals with high blood pressure should use this medication with caution and under medical supervision, as it may increase blood pressure.
• Those with diabetes may need to monitor their blood sugar levels more frequently, as this medication can affect glucose control.
• If you have a history of liver disease, your liver function should be monitored regularly while taking this medication.
• Certain medications, such as rifampicin, phenytoin, and St. John's Wort, can reduce the effectiveness of this tablet, so consult your doctor about potential drug interactions.

Following are the drug interactions for Ethinyloestradiol, Desogestrel Tablet:

• May reduce the effectiveness of lamotrigine, leading to decreased seizure control. Monitoring and dose adjustments may be necessary.
• Can decrease the efficacy of antibiotics like rifampicin and rifabutin, potentially reducing contraceptive reliability. Consider using backup contraception during and shortly after antibiotic treatment.
• The effectiveness of Ethinyloestradiol, Desogestrel may be reduced by certain anticonvulsants like phenytoin, carbamazepine, and topiramate, increasing the risk of unintended pregnancy.
• St. John's Wort (Hypericum perforatum) can decrease the plasma concentrations of Ethinyloestradiol, Desogestrel, reducing its contraceptive effect.
• May influence the metabolism of medications metabolized by CYP3A4, such as cyclosporine, leading to potentially increased side effects.
• Ethinyloestradiol may increase blood levels of the anticoagulant warfarin, possibly requiring dosage adjustments.
• Certain antiretroviral agents (e.g., ritonavir, efavirenz) can decrease the effectiveness of Ethinyloestradiol, Desogestrel, requiring alternative contraceptive methods.

Following are the food interactions for Ethinyloestradiol, Desogestrel Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the levels of the hormones in the blood, potentially leading to increased side effects.
• Alcohol may not directly interact with the medication, but it's generally recommended to limit alcohol consumption to reduce the risk of liver-related issues and potential hormonal imbalances.
• Fatty or greasy foods may not directly affect the medication's absorption, but maintaining a healthy diet is essential while taking hormonal contraceptives.
• Avoid vitamin C supplements or excessive intake of foods rich in vitamin C, as they may interfere with the medication's effectiveness.
• Limit caffeine intake, as it can increase the metabolism of the hormones, potentially reducing their effectiveness.
• Avoid herbal supplements like St. John's Wort, as it can decrease the medication's efficacy.
• Consult your healthcare provider about specific dietary restrictions or recommendations, especially if you have pre-existing medical conditions.
• No significant food interactions have been reported with this medication, but it's best to maintain a balanced diet and follow healthcare advice.

Ethinyloestradiol, Desogestrel Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It is crucial to store the medication at room temperature, away from direct sunlight, heat, and moisture, as these factors can degrade the tablets. Do not refrigerate or freeze the tablets. Always check the expiration date, and dispose of any expired or unused tablets promptly. Proper disposal methods include returning them to a pharmacy or a healthcare facility for safe disposal, ensuring they do not contaminate the environment or pose a risk to others. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Ethinyloestradiol, Desogestrel Tablet:

• Consult your doctor for the correct dosage and prescription.
• Take the tablet at the same time each day as instructed.
• Swallow the tablet whole with a full glass of water.
• Avoid crushing, chewing, or breaking the tablet.
• If you experience nausea, taking the tablet with food may help.
• Inform your doctor if you have any medical conditions or allergies.
• Store the medication in a cool, dry place, away from direct sunlight.
• Do not share this medication with others, even if their symptoms are similar.