Detrusitol (2mg) 28 Tablets

Detrusitol (2mg) 28 Tablets

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  • Manufacturer PFIZER LABORATORIES LTD
  • Generic Name Tolterodine

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Tolterodine 2mg Tablet works by selectively blocking the M3 subtype of muscarinic receptors in the bladder, which are responsible for bladder contractions. By inhibiting these receptors, tolterodine relaxes the detrusor muscle, leading to increased bladder capacity and reduced urgency and frequency of urination. This mechanism helps to alleviate symptoms associated with overactive bladder, such as urinary incontinence, urgency, and frequent urination, without affecting bladder contraction during urination.

  • Ingredients

    Tolterodine
  • Drug Class

    Antimuscarinic.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Tolterodine 2mg Tablet:

    • Used for overactive bladder, reducing frequent and uncontrolled urine release.
    • Used to relieve sudden strong urges to urinate.
    • Used to treat incontinence, helping patients gain better control over their bladder.
    • Used to decrease the frequency of urination, especially at night.
    • Used to manage symptoms of an enlarged prostate, improving urine flow.
    • Used to alleviate bladder spasms and associated discomfort.
    • Used to improve quality of life by providing better bladder control.
  • In case of Overdose

    In the case of an overdose of Tolterodine 2mg Tablets, several symptoms may occur, including dry mouth, blurred vision, dizziness, and difficulty urinating. It is important to recognize these signs and respond promptly. If you suspect an overdose, seek medical advice immediately. Treatment options may include supportive care, such as providing fluids and ensuring the patient's airway is clear, while also monitoring vital signs and administering medications to manage any adverse effects.

  • Missed Dose

    In the case of a missed dose of Tolterodine 2mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

  • How To Use

    To take Tolterodine 2mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once or twice a day.

  • When Not to Use

    Following are the conditions when Tolterodine 2mg Tablet should not be used:

    • Should not be used in individuals with a known allergy to Tolterodine or any of its ingredients.
    • Not suitable for patients with untreated or uncontrolled narrow-angle glaucoma.
    • Contraindicated in patients with urinary retention or gastric retention issues.
    • Should not be used in individuals with severe liver impairment.
    • Not recommended for patients with severe kidney disease requiring dialysis.
    • Contraindicated in patients with gastro-intestinal obstruction or severe constipation.
    • Avoid using it if you have uncontrolled narrow-angle glaucoma or a condition called 'myasthenia gravis'.
  • Side Effects

    The side effects of Tolterodine 2mg Tablet may include:

    • Dry mouth
    • Constipation
    • Blurred vision
    • Dizziness
    • Fatigue or drowsiness
    • Headache
    • Stomach pain
    • Difficulty urinating
  • Precautions & Warnings

    Following are the precautions and warnings for Tolterodine 2mg Tablet:

    • This medication should be used with caution in patients with kidney or liver disease, as it may require dosage adjustments.
    • Patients with narrow-angle glaucoma should exercise caution and inform their doctor before taking this medicine.
    • Tolterodine may cause blurred vision or drowsiness; patients should avoid driving or operating heavy machinery until they know how this medication affects them.
    • It may lead to increased body temperature, especially in hot weather conditions, so stay hydrated and avoid excessive heat.
    • Elderly patients may be more sensitive to the side effects, especially confusion and hallucinations.
    • Tolterodine should be used with caution in patients with a history of gastrointestinal obstruction or urinary retention.
    • This medication may interact with other drugs; inform your doctor about all medications you are currently taking.
  • Drug Interactions

    Following are the drug interactions for Tolterodine 2mg Tablet:

    • Antimuscarinic drugs like antipsychotics, tricyclic antidepressants, or antihistamines can enhance the anticholinergic effects, leading to increased side effects such as dry mouth, blurred vision, and constipation.
    • Tolterodine may interact with certain medications metabolized by the CYP3A4 enzyme, including ketoconazole, erythromycin, and protease inhibitors, potentially affecting the metabolism of these drugs.
    • Use with potassium-sparing diuretics may increase the risk of hyperkalemia, requiring close monitoring of potassium levels.
    • Caution is advised when combining Tolterodine with other medications that can cause urinary retention, such as certain alpha-blockers or anticholinergic agents.
    • Drugs that can lower gastric acidity, like proton pump inhibitors or H2 blockers, may affect the absorption of Tolterodine.
    • It may interact with certain antiarrhythmic medications, like amiodarone, potentially affecting heart rate and rhythm.
    • Tolterodine can increase the risk of mydriasis when used with other anticholinergic agents, such as atropine.
  • Food Interactions

    Following are the food interactions for Tolterodine 2mg Tablet:

    • Consuming alcohol with Tolterodine may cause excessive drowsiness and dizziness, as alcohol can enhance the sedative effects of the medication.
    • Grapefruit and its juice should be avoided as they can interfere with the metabolism of Tolterodine, potentially leading to increased drug levels in the body and a higher risk of side effects.
    • High-fat meals may slightly delay the absorption of Tolterodine, but this effect is generally not clinically significant and does not require a change in dosing.
    • Avoid excessive consumption of citrus fruits, especially Seville oranges, as they can inhibit the CYP3A4 enzyme, leading to increased Tolterodine levels.
    • Limit the intake of apple, orange, and grapefruit juices, as they can alter the pH of the stomach and potentially affect the dissolution and absorption of Tolterodine.
    • Dairy products like milk and yogurt may slightly reduce the absorption of Tolterodine. Consider separating the medication from these products by a few hours.
    • Some herbal teas, particularly those containing St. John's Wort, may interact with Tolterodine, potentially reducing its effectiveness. Consult your healthcare provider before using herbal products.
    • Always ensure you are well-hydrated when taking Tolterodine to aid in the medication's dissolution and absorption process.
  • Storage/Disposal

    Tolterodine 2mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. The original packaging should be tightly sealed to maintain its integrity and protect it from environmental factors. It is crucial not to store the medication in the bathroom or kitchen, as these areas may expose it to humidity and temperature fluctuations. Regularly check the expiration date, and if the tablets are expired or no longer needed, proper disposal is essential. Do not dispose of them in household waste or flush them down the toilet; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Tolterodine 2mg Tablet:

    • Take the tablet as directed by your doctor; do not crush or chew it.
    • Consume the tablet with a full glass of water for easy swallowing.
    • Maintain a consistent schedule by taking the medication at the same time each day.
    • If you experience dryness in the mouth, try chewing sugar-free gum or sucking on ice chips.
    • Avoid alcohol and hot beverages as they can aggravate urinary symptoms.
    • Inform your doctor if you have any gastrointestinal issues or eye problems.
    • Store the medication in a cool, dry place, away from direct sunlight.

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