Detrusitol SR (4mg) 14 Capsules

Tolterodine 4mg capsules primarily exert their therapeutic effects by selectively blocking muscarinic receptors, specifically the M3 subtype, in the bladder muscle and urothelium. This mechanism of action is crucial in managing overactive bladder symptoms. By antagonizing these receptors, tolterodine inhibits the binding of acetylcholine, a neurotransmitter responsible for triggering bladder contractions. Consequently, the bladder's detrusor muscle relaxes, leading to reduced urgency, frequency, and urge incontinence associated with overactive bladder conditions. The selective nature of tolterodine's action helps minimize unwanted side effects on other muscarinic receptors in the body, thereby enhancing its therapeutic profile.

Anticholinergic (muscarinic).

Capsule

The following are the uses of Tolterodine 4mg Capsule:

• Used for treating overactive bladder and relieving symptoms like frequent urination and sudden urges to urinate.
• Used to help control bladder contractions and reduce accidental urine leakage.
• Used to improve bladder control and reduce the need for frequent bathroom visits.
• Used to manage incontinence, especially in patients with an urgent need to urinate.
• Used to enhance quality of life by reducing the disruption caused by overactive bladder symptoms.
• Used as a long-term treatment option to manage chronic bladder issues.
• Used to provide relief from bladder spasms and associated discomfort.

In the case of an overdose of Tolterodine 4mg Capsules, individuals may experience symptoms such as blurred vision, dizziness, dry mouth, and difficulty urinating. Promptly seek medical advice or contact a healthcare professional if you suspect an overdose. Treatment options for overdose may include supportive care, observation, and symptomatic management. It is important to provide healthcare providers with detailed information regarding the quantity ingested and the time of overdose to ensure appropriate treatment.

In the case of a missed dose of Tolterodine 4mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is essential to maintain consistency in taking your medication as prescribed by your healthcare provider.

To take Tolterodine 4mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken once or twice daily as directed.

Here are the conditions or situations when Tolterodine 4mg Capsule should not be taken:

• Should not be used in individuals with a known allergy to Tolterodine or similar medications.
• Contraindicated in patients with untreated or uncontrolled narrow-angle glaucoma.
• Not suitable for individuals with urinary retention or gastric retention issues.
• Should not be used in patients with uncontrolled narrow-angle glaucoma.
• Contraindicated in patients with severe liver impairment or liver failure.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Should be avoided in patients with a history of gastrointestinal obstruction.

The side effects of Tolterodine 4mg Capsule may include:

• Dry mouth
• Constipation
• Blurred vision
• Dizziness
• Fatigue or drowsiness
• Headache
• Stomach pain
• Difficulty urinating

Following are the precautions and warnings for Tolterodine 4mg Capsule:

• Not recommended for individuals with gastrointestinal obstruction, uncontrolled narrow-angle glaucoma, urinary retention, or uncontrolled/unmanaged severe gastrointestinal disorders.
• Tolterodine should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• May cause blurred vision or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Alcohol consumption should be avoided as it may worsen side effects.
• Not recommended for children and adolescents under 18 years of age.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may affect fetal development and may pass into breast milk.
• Patients with a history of gastrointestinal obstruction, urinary retention, or glaucoma should inform their doctor before starting this medication.
• Tolterodine may interact with other medications; inform your healthcare provider of all medications you are currently taking.

Following are the drug interactions for Tolterodine 4mg Capsule:

• Antimuscarinic agents or other medications with similar effects may have additive side effects when used together.
• The use of strong CYP3A4 inhibitors like ketoconazole can increase the concentration of tolterodine, potentially requiring a dose adjustment.
• Tolterodine may interact with anticholinesterase agents, leading to decreased therapeutic effects of both drugs.
• It can increase the risk of mydriasis when taken with certain eye medications like atropine.
• The absorption of Tolterodine can be affected by antacids containing aluminum or magnesium, leading to reduced effectiveness.
• Medications that prolong QT interval, such as certain antiarrhythmics, should be used cautiously due to potential cardiac effects.
• Tolterodine may interact with some antihistamines, resulting in increased anticholinergic effects.

Following are the food interactions to be aware of with Tolterodine 4mg Capsule:

• Grapefruit and grapefruit juice consumption should be avoided as they can inhibit the metabolism of Tolterodine, leading to increased drug levels in the body and potentially causing more side effects.
• Alcohol intake is generally not recommended as it can increase the sedative effects of Tolterodine, resulting in enhanced dizziness and drowsiness.
• Avoid consuming large amounts of dairy products, as they may decrease the absorption of Tolterodine, making the medication less effective.
• Consuming high-fat meals might affect the absorption of Tolterodine, potentially delaying its onset of action.
• Caffeine-rich beverages like coffee and tea may increase the frequency and urgency of urination, working against the purpose of Tolterodine.
• Drinking plenty of fluids, especially water, is essential to maintain hydration and support the effectiveness of the medication in managing overactive bladder symptoms.
• A balanced diet with a variety of fruits, vegetables, whole grains, and lean proteins can help maintain overall health and potentially reduce the severity of overactive bladder symptoms.
• There are no specific food restrictions, but it's advisable to follow the dietary guidelines provided by your healthcare professional for optimal management of your condition.

Tolterodine 4mg Capsules should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the capsules from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to air. Do not use the capsules if there are signs of tampering or if the packaging appears damaged. When disposing of unused or expired capsules, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for advice on safe disposal methods, ensuring environmental responsibility. Keep the medication away from children and pets to prevent accidental ingestion.

Following are the quick tips for Tolterodine 4mg Capsule:

• Take the capsule as directed by your doctor, typically twice a day.
• Swallow the capsule whole with a full glass of water; do not crush or chew.
• Maintain a consistent schedule for taking the medication for maximum effectiveness.
• Avoid alcohol and caffeine while taking this medication to prevent side effects.
• Inform your doctor if you have any allergies or medical conditions before starting this medicine.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Do not share this medication with others, even if they have similar symptoms.