Dex-D (60mg) 30 Capsules

Dexlansoprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by targeting the gastric acid pump (H+/K+ ATPase) within the parietal cells of the stomach. This medication forms a covalent bond with two cysteine residues in the proton pump's α-subunit, resulting in effective and long-lasting inhibition of gastric acid secretion. The mechanism involves the accumulation of dexlansoprazole in the acidic environment of the parietal cells' secretory canaliculus, where it is converted to its active form. This active form then binds to the proton pump, inhibiting its function and reducing gastric acid production.

Dexlansoprazole 60mg

Proton pump inhibitor.

Capsule

The following are the uses of Dexlansoprazole 60mg Capsule:

• Used for treating gastroesophageal reflux disease (GERD)
• Used to provide long-term relief from persistent heartburn and heal damaged esophageal tissue
• Used for patients with a history of GERD who require continuous therapy
• Used to reduce stomach acid production and prevent acid reflux
• Used to treat symptoms like acid regurgitation, difficulty swallowing, and persistent cough
• Used for managing nighttime acid breakthrough, improving sleep quality
• Used to treat duodenal ulcers, allowing the ulcer to heal and preventing recurrence

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Heartburn and acid reflux Take one capsule of Dexlansoprazole 30mg once daily in the morning before eating.
• Duodenal/gastric ulcer Take one capsule of Dexlansoprazole 30mg once daily for 4 weeks.

In the case of an overdose of Dexlansoprazole 60mg Capsules, it is important to recognize the potential severity of this situation. Overdosing on this medication may lead to an increase in the intensity of its side effects, including but not limited to headaches, dizziness, and gastrointestinal issues. Promptly seek medical advice or assistance if you suspect an overdose, as healthcare professionals can provide guidance on the necessary steps to mitigate potential health risks associated with excessive consumption of this medication.

In the case of a missed dose of Dexlansoprazole 60mg Capsule, it is recommended to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to resume your medication safely, especially if you are experiencing persistent or worsening symptoms.

To take Dexlansoprazole 60mg Capsule, swallow the capsule whole with a full glass of water, preferably in the morning on an empty stomach, at least one hour before a meal, as directed by your healthcare provider.

Following are the conditions when Dexlansoprazole 60mg Capsule should not be used:

• Do not take if you have a known allergy or hypersensitivity to Dexlansoprazole or other proton pump inhibitors (PPIs).
• Avoid using this medication if you have low magnesium levels in your blood (hypomagnesemia).
• Do not use Dexlansoprazole if you are currently taking a medication that contains rilpivirine, as it can reduce its effectiveness.
• It is contraindicated in patients with severe liver impairment, as the dosage adjustment cannot be achieved with the available strength.
• Should not be used if you have a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Dexlansoprazole 60mg Capsule may include:

• Diarrhea
• Abdominal pain
• Nausea
• Headache
• Dizziness
• Skin rash
• Fatigue
• Increased liver enzymes

Following are the precautions and warnings for Dexlansoprazole 60mg Capsule:

• Not recommended for individuals with known allergies to Dexlansoprazole or other proton pump inhibitors.
• Patients with liver or kidney disease should use with caution and under medical supervision as dosage adjustments might be necessary.
• Long-term use may increase the risk of bone fractures, so regular monitoring of bone mineral density is advised.
• May interact with certain medications, including diazepam, warfarin, and phenytoin, so consult a healthcare professional before combining treatments.
• Patients should inform their doctor about all medications they are taking to avoid potential drug interactions.
• This medication may mask symptoms of other conditions; if new or persistent symptoms occur, seek medical advice.
• Consult a doctor if you have any gastrointestinal issues or a history of low magnesium levels before starting this medication.

Following are the drug interactions for Dexlansoprazole 60mg Capsule:

• Dexlansoprazole may increase plasma concentrations of drugs metabolized by CYP2C19 and CYP3A4 enzymes, such as diazepam, warfarin, and phenytoin, requiring dose adjustments.
• Concomitant use with digoxin can increase digoxin levels, necessitating monitoring.
• Dexlansoprazole may reduce the absorption of ketoconazole, iron, and other drugs dependent on gastric pH for absorption.
• It can decrease the effectiveness of certain antiretroviral medications, like atazanavir and nelfinavir.
• May reduce plasma concentrations of methotrexate.
• The absorption of erlotinib may be decreased, potentially reducing its effectiveness.
• Dexlansoprazole can increase plasma concentrations of tacrolimus, requiring careful monitoring.

Following are the food interactions for Dexlansoprazole 60mg Capsule:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it can affect the metabolism of Dexlansoprazole, potentially increasing its levels in the body and the risk of side effects.
• Limit or avoid alcohol consumption as it can irritate the stomach and increase the potential for gastrointestinal side effects when combined with Dexlansoprazole.
• Avoid high-fat meals as they can delay the absorption and reduce the effectiveness of Dexlansoprazole. It is best to take the medication on an empty stomach.
• Caffeinated beverages like coffee or tea might stimulate acid production and potentially interfere with the medication's effect, so it's advisable to limit their intake.
• Spicy foods can trigger acid reflux and heartburn, which may reduce the effectiveness of Dexlansoprazole. Consider reducing spicy food intake.
• Chocolate contains a compound that can relax the lower esophageal sphincter, potentially triggering acid reflux. It's best to consume chocolate in moderation while on Dexlansoprazole.
• Some dairy products, especially high-fat ones, might worsen acid reflux symptoms. Opt for low-fat dairy alternatives when possible.
• Avoid carbonated drinks as they can contribute to gas and bloating, potentially increasing discomfort in individuals with acid-related conditions.

Dexlansoprazole 60mg Capsules should be stored in a cool and dry place, preferably at room temperature (68°F to 77°F or 20°C to 25°C). Keep the capsules in their original container, tightly sealed, to protect them from moisture and light. It is crucial to store medications away from heat and direct sunlight, so avoid placing them near stoves, heaters, or windows. Always check the expiration date on the packaging and do not use the capsules if they are past their expiry date. When disposing of unused or expired capsules, do not flush them down the toilet or pour them into the drain. Consult your pharmacist or healthcare professional for guidance on safe disposal practices to protect the environment. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Dexlansoprazole 60mg Capsule:

• Swallow the capsule whole; do not crush, chew, or break it.
• Take the capsule in the morning, preferably at least one hour before a meal.
• Avoid missing doses; take it at regular intervals for maximum effectiveness.
• Ensure you complete the prescribed course, even if you feel better earlier.
• Inform your doctor if you have liver problems or are pregnant/breastfeeding.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.

Dexlansoprazole is a medication used to treat GERD and ulcers in the stomach or intestine. While lab tests are not required for everyone who takes Dexlansoprazole, they are sometimes necessary to monitor specific side effects and overall health. People with kidney problems or a history of acute interstitial nephritis, an inflammation of the kidneys, may need to undergo regular lab tests to monitor their kidney function. These tests measure kidney function and check for any worsening of their kidney status, including serum creatinine and blood urea nitrogen (BUN) examinations. Those with a history of bone density issues, such as osteoporosis or osteopenia, may need lab tests to assess their bone health. This includes measuring serum calcium levels and bone mineral density tests to ensure the medication does not adversely affect their bones. Individuals with a history of vitamin B12 deficiency or low vitamin B12 levels should potentially undergo routine monitoring of vitamin B12 levels to prevent deficiency and complications. Those with a history of gastrointestinal infections or chronic liver disease may also need additional lab tests to monitor their condition. These tests could include complete blood counts or comprehensive metabolic panels, which give insights into the patient's overall health. It is important to note that the need for lab tests while taking Dexlansoprazole is not universal and depends on each individual's specific health history and conditions. It is recommended to consult a healthcare professional before taking Dexlansoprazole 30mg to determine which lab tests, if any, are required.