Dexamethasone (0.5mg) 100 Tablets

Dexamethasone, a potent synthetic glucocorticoid, exerts its effects primarily by modulating gene expression. Once inside the cell, it binds to specific glucocorticoid receptors (GRs) in the cytoplasm. This binding induces a conformational change in the GR, causing it to dissociate from its chaperone proteins. The activated GR complex then migrates into the cell nucleus, where it can bind to glucocorticoid response elements (GREs) in the DNA. This binding to GREs results in the regulation of gene transcription. Dexamethasone primarily acts as a transrepression agent, meaning it suppresses the expression of various inflammatory genes by inhibiting the action of transcription factors such as AP-1 and NF-κB. This transrepression activity is responsible for the potent anti-inflammatory and immunosuppressive effects of dexamethasone, making it effective in treating conditions where inflammation is a significant factor.

Dexamethasone

Corticosteroid.

Tablet

The following are the uses of Dexamethasone Tablet:

• Used for reducing inflammation and suppressing the immune system in various conditions, such as severe allergies, asthma, and autoimmune disorders.
• Used for treating skin disorders like eczema, psoriasis, and severe dermatitis.
• Used for managing brain swelling and reducing inflammation in brain injuries or after brain surgery.
• Used for alleviating joint pain and swelling in rheumatoid arthritis and other inflammatory joint conditions.
• Used for treating certain types of cancer, particularly in managing side effects of chemotherapy.
• Used for eye conditions like severe eye allergies, inflammation, and macular edema.
• Used for short-term treatment of sudden hearing loss.
• Used for relieving nausea and vomiting in certain medical conditions.

To be taken as per doctor's prescription

In the case of an overdose of Dexamethasone Tablets, individuals may experience a range of symptoms depending on the severity. Common signs include increased heart rate, elevated blood pressure, and potential mood changes such as restlessness or irritability. In more serious cases, individuals may suffer from severe headaches, blurred vision, or even seizures. It is important to seek medical advice promptly, as the healthcare provider will determine the appropriate treatment based on the individual's specific symptoms and overall health condition.

In the case of a missed dose of Dexamethasone Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions to help you get back on track with your medication regimen. It is always best to take your medication as prescribed to ensure its effectiveness.

To take the Dexamethasone Tablet, swallow the tablet whole with a glass of water, following the prescribed dosage as directed by your healthcare professional, typically once or twice a day, with or without food, depending on the medical condition being treated.

Following are the conditions when Dexamethasone Tablet should not be used:

• Must not be used in patients with systemic fungal infections unless treated with specific antifungal agents.
• Contraindicated in patients with widespread bacterial infections unless treated with appropriate antibiotics.
• Should not be used in patients with known hypersensitivity or severe allergic reactions to dexamethasone or other glucocorticoids.
• Not recommended for patients with active tuberculosis.
• Avoid using in patients with idiopathic thrombocytopenic purpura (ITP) who are at risk of systemic hemorrhage.
• Do not administer to patients with active or latent peptic ulcer disease, as it can increase the risk of gastrointestinal bleeding.
• Should be used with caution in patients with a history of recent myocardial infarction, as it can delay wound healing.
• Not suitable for patients with severe psychiatric disturbances, as it may exacerbate symptoms.
• Avoid using in patients with glaucoma or a history of cataract development.
• Not recommended for patients with severe osteoporosis, as it can lead to bone loss.

The side effects of Dexamethasone Tablet may include:

• Increased appetite and weight gain
• Nausea, indigestion, or stomach pain
• Mood changes, including feeling anxious or restless
• Difficulty sleeping (insomnia)
• Skin thinning or bruising
• Delayed wound healing
• Muscle weakness
• Headache

Here are the precautions and warnings for Dexamethasone Tablet:

• Dexamethasone should be used with caution in patients with a history of allergies, especially to corticosteroids, as it may trigger allergic reactions.
• Patients with diabetes should monitor their blood sugar levels closely as this medication can increase blood glucose.
• Prolonged use or high doses may lead to suppression of the adrenal glands, so regular monitoring is necessary.
• It may cause fluid retention, so caution is advised in patients with heart, kidney, or liver conditions.
• Dexamethasone can weaken the immune system, making patients more susceptible to infections.
• Avoid sudden discontinuation as it may lead to withdrawal symptoms; gradually reduce the dosage under medical supervision.
• This medication may affect growth in children and adolescents, so growth should be monitored regularly.

Following are the drug interactions for Dexamethasone Tablet:

• Co-administration with live vaccines is not recommended as Dexamethasone may decrease the body's immune response.
• Blood pressure-lowering effects of antihypertensive medications may be reduced by Dexamethasone.
• Combining with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of gastrointestinal bleeding.
• Dexamethasone may decrease the levels of antidiabetic medications, requiring adjustments in dosage.
• The effectiveness of anticoagulants like warfarin can be altered, requiring close monitoring of coagulation parameters.
• It may interact with CYP3A4 inhibitors or inducers, potentially leading to increased or decreased Dexamethasone levels.
• Concomitant use with antiepileptic drugs can lower seizure threshold, requiring dosage adjustments.

Following are the food interactions for Dexamethasone Tablet:

• Avoid excessive salt intake as Dexamethasone can cause sodium retention, leading to increased blood pressure.
• Grapefruit and grapefruit juice should be consumed cautiously as they may alter the drug's metabolism, affecting blood levels.
• Alcohol may increase the risk of gastrointestinal issues, so limit or avoid alcohol consumption.
• High-potassium foods like bananas, oranges, and spinach should be monitored as Dexamethasone can cause potassium loss.
• Calcium-rich foods like dairy products might require adjustment as Dexamethasone can affect calcium absorption.
• Dexamethasone can impact blood sugar levels, so monitor carbohydrate intake and choose complex carbs for better control.
• Ensure a balanced diet to maintain overall health, especially during long-term Dexamethasone use.

Dexamethasone Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, including heat sources like radiators or stoves, as this can impact its effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for guidance on proper disposal methods, and always keep medicines out of the reach of children to prevent accidental ingestion. This ensures the safe and effective management of Dexamethasone Tablets throughout their shelf life.

Yes

Following are the quick tips for Dexamethasone Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Ensure you understand the prescribed dosage and duration of treatment.
• Dexamethasone can be taken with or without food, but taking it with food may reduce stomach irritation.
• Swallow the tablet whole with a full glass of water for easier swallowing.
• Avoid crushing, chewing, or breaking the tablet unless advised by your doctor.
• Do not abruptly stop taking this medication; follow your doctor's instructions for tapering the dose.
• Inform your healthcare provider about all your medications to prevent potential drug interactions.