DIABETRON CR 90 MG TAB

Gliclazide, a second-generation sulfonylurea, primarily acts by stimulating insulin release from pancreatic beta cells. It achieves this by selectively binding to sulfonylurea receptors on the beta-cell membrane, leading to the inhibition of ATP-sensitive potassium channels. This inhibition results in membrane depolarization, causing calcium influx and subsequent insulin secretion. This mechanism enhances the body's ability to manage blood glucose levels, making gliclazide effective in treating type 2 diabetes.

Gliclazide 90mg

Sulfonylurea (antidiabetic drug).

Tablet

The following are the uses of Gliclazide 90mg Tablet:

• Used for treating type 2 diabetes
• Used to lower blood sugar levels
• Used to improve insulin sensitivity
• Used to manage diabetes when diet and exercise alone are not sufficient
• Used to help prevent diabetic complications
• Used to control glucose levels after meals
• Used as a long-term treatment option for stable blood sugar control
• Used in combination with other diabetes medications if needed

In the case of an overdose of Gliclazide 90mg Tablets, individuals may experience symptoms such as severe hypoglycemia, characterized by tremors, sweating, and confusion. The severity of the reaction depends on the amount ingested. Prompt medical intervention is necessary, as it may require hospitalization for monitoring and treatment. It is crucial to contact emergency services immediately if an overdose is suspected to ensure appropriate care and management of symptoms.

In the case of a missed dose of Gliclazide 90mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. However, if you frequently miss doses, inform your healthcare provider, as they may provide specific instructions for managing missed doses to ensure the medication's effectiveness. It is advisable to maintain a consistent dosing routine to maximize the benefits of the treatment.

To take Gliclazide 90mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, once or twice daily as directed by your doctor, and do not crush, chew, or break the tablet.

Following are the conditions/situations when Gliclazide 90mg Tablet should not be taken:

• Avoid if you have a known allergy to Gliclazide or any related sulfonylurea drugs.
• Not suitable for individuals with type 1 diabetes mellitus or diabetic ketoacidosis.
• Should not be used if you have severe liver or kidney disease.
• Contraindicated in individuals with porphyria, a rare genetic disorder.
• Not recommended for those with a history of severe blood disorders or anemia.
• Avoid if you have a severe infection, trauma, or are recovering from surgery.
• Do not take if you are breastfeeding, as it may pass into breast milk.
• Gliclazide is not intended for use in children and adolescents under 18 years of age.

The side effects of Gliclazide 90mg Tablet may include:

• Hypoglycemia (low blood sugar)
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or constipation
• Skin rash or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Weight gain
• Blurred vision

Following are the precautions and warnings for Gliclazide 90mg Tablet:

• Gliclazide should not be used in patients with a known allergy or hypersensitivity to sulfonylureas or any of the tablet's components.
• This medication is not recommended for patients with diabetic ketoacidosis or type 1 diabetes mellitus.
• Caution is advised for patients with liver or kidney disease, as Gliclazide may need to be adjusted or monitored closely.
• Alcohol consumption should be avoided or limited while taking this medication, as it can increase the risk of hypoglycemia.
• Patients should be aware of the symptoms of hypoglycemia and hyperglycemia and know how to manage them.
• Gliclazide may cause blurred vision or dizziness; activities requiring alertness should be avoided until the individual's response to the medication is known.
• Elderly patients may be more sensitive to the effects of Gliclazide, and dosage adjustments might be necessary.
• Inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Gliclazide 90mg Tablet:

• Alcohol consumption may affect blood glucose levels and should be avoided or limited while taking this medication.
• Drugs that affect liver enzymes, such as rifampicin, can alter Gliclazide metabolism, potentially reducing its effectiveness.
• It may interact with other antidiabetic medications, including insulin, leading to hypoglycemia. Close monitoring of blood sugar is necessary.
• Gliclazide can increase the effects of sulfonamides, potentially increasing the risk of side effects.
• Certain antibiotics, like clarithromycin or erythromycin, can inhibit the breakdown of Gliclazide, leading to increased drug levels.
• Beta-blockers may mask the symptoms of hypoglycemia, making it harder to detect low blood sugar.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the hypoglycemic effect of Gliclazide, requiring careful monitoring.

Following are the food interactions for Gliclazide 90mg Tablet:

• Grapefruit juice should be used with caution as it may increase the blood levels of Gliclazide, potentially leading to hypoglycemia.
• Alcohol consumption can cause a decrease in blood sugar levels, so monitor blood sugar closely and adjust the dose if needed.
• High-sugar foods and beverages can lead to unpredictable increases in blood glucose levels, so it is advisable to consume them in moderation.
• Avoid excessive caffeine intake as it may interfere with blood sugar control.
• Fatty meals can delay the absorption of Gliclazide, affecting its effectiveness.
• Avoid or limit the use of cranberry juice as it can increase the effects of Gliclazide, leading to a higher risk of hypoglycemia.
• Garlic may enhance the blood-sugar-lowering effect, so monitor blood glucose levels closely when consuming garlic in large amounts.
• Fenugreek seeds may have a synergistic effect with Gliclazide, so be cautious and monitor blood sugar when using them together.

Gliclazide 90mg Tablets should be stored in a cool and dry place, preferably in their original container, away from direct sunlight, heat, and moisture. It is crucial to maintain a stable room temperature to preserve the medication's effectiveness. Always keep the tablets out of reach of children and pets to prevent accidental consumption. When disposing of unused or expired tablets, do not flush them down the toilet or discard them in household waste. Instead, follow local guidelines or consult your pharmacist for safe disposal methods to protect the environment and prevent misuse. Ensure that the medication is stored securely and responsibly to maintain its integrity and avoid any potential risks.

Following are the quick tips for Gliclazide 90mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet whole with a glass of water, do not crush or chew.
• Maintain a consistent dosing schedule to ensure stable blood sugar levels.
• Avoid skipping or doubling doses; follow your doctor's instructions.
• Inform your doctor if you have liver or kidney problems before taking this medication.
• Do not take this tablet if you are allergic to any of its ingredients.
• Store in a cool, dry place, away from direct sunlight and moisture.