DIBENYLINE IMP CAP (PHENOXYBENAZIME)

Phenoxybenzamine, the active ingredient in PHENOXYBENAMINE capsules, is a non-selective, irreversible alpha-adrenergic antagonist. Its primary mechanism of action involves blocking both alpha-1 and alpha-2 adrenergic receptors. By binding to these receptors, phenoxybenzamine prevents the activation of the sympathetic nervous system's effects. This leads to vasodilation, reduced peripheral vascular resistance, and decreased blood pressure. Additionally, it inhibits the release of norepinephrine from sympathetic nerve endings, further contributing to its antihypertensive effects. The irreversible nature of its binding allows phenoxybenzamine to exert prolonged pharmacological actions, making it useful in managing certain medical conditions such as hypertension and pheochromocytoma.

Alpha-adrenergic antagonist

Capsule

The following are the uses of PHENOXYBENAMINE Capsule:

• Used for controlling high blood pressure in emergencies.
• Used to quickly lower blood pressure in life-threatening situations.
• Used for managing hypertensive crises to stabilize vital signs.
• Used to provide rapid relief during a sudden increase in blood pressure.
• Used to prevent potential complications from severe hypertension.
• Used as part of a comprehensive treatment plan for blood pressure management.
• Used to reduce the risk of heart attack or stroke due to hypertension.
• Used in situations where immediate blood pressure control is crucial.

In the case of an overdose of PHENOXYBENAMINE capsules, the severity of symptoms may vary depending on the amount ingested. Initial signs can include dizziness, severe dry mouth, and blurred vision. More serious effects might involve a rapid or weak pulse, fainting, and difficulty breathing. Prompt medical intervention is necessary, including contacting poison control or emergency services, as they can provide specific guidance and treatment options for managing the overdose effectively.

In the case of a missed dose of PHENOXYBENAMINE capsules, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. However, do not double the dose to make up for the missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is advisable to consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take the PHENOXYBENAMINE Capsule, swallow the capsule whole with a full glass of water, ensuring you follow the prescribed dosage and timing instructions provided by your healthcare professional.

Following are the conditions when PhenoXYbenamine Capsule should not be used:

• Must not be taken by individuals with a known allergy to PhenoXYbenamine or similar medications.
• Not suitable for patients with narrow-angle glaucoma.
• Contraindicated in individuals with severe kidney disease or kidney failure.
• Should not be used during severe coronary artery disease or recent heart attack.
• Avoid using this medication if you have urinary retention or an enlarged prostate.
• Not recommended for patients with pheochromocytoma, a tumor of the adrenal gland.
• Must be avoided by patients with a history of gastrointestinal obstruction or paralytic ileus.

The side effects of PHENOXYBENAMINE Capsule may include:

• Dizziness
• Fatigue
• Dry mouth
• Constipation
• Blurred vision
• Difficulty urinating
• Rapid heartbeat
• Confusion

Following are the precautions and warnings for PHENOXYBENAMINE Capsule:

• Not recommended for patients with narrow-angle glaucoma, as it may worsen the condition and increase intraocular pressure.
• Patients with cardiovascular diseases such as hypertension, coronary artery disease, or heart failure should use with caution and under medical supervision.
• Elderly individuals may be more susceptible to side effects, particularly dizziness and drowsiness, so dosage adjustments might be necessary.
• Not suitable for individuals with known allergies or hypersensitivity to PHENOXYBENAMINE or other similar medications.
• May cause dizziness and drowsiness, affecting mental alertness. Avoid driving or operating heavy machinery until you know how the medication affects you.
• Use with caution in patients with prostatic hypertrophy, as it may exacerbate urinary retention.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its safety during pregnancy and lactation has not been fully established.
• Always inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for PHENOXYBENAMINE Capsule:

• PHENOXYBENAMINE may interact with other alpha-blockers, leading to a potential drop in blood pressure and orthostatic hypotension.
• Concomitant use with tricyclic antidepressants can result in an increased risk of cardiovascular side effects.
• It may decrease the effectiveness of beta-blockers, which are commonly used to treat hypertension and heart conditions.
• PHENOXYBENAMINE can potentially interact with monoamine oxidase inhibitors (MAOIs), causing a severe increase in blood pressure.
• Use with vasodilators may lead to excessive hypotension and a rapid decrease in blood pressure.
• It can interact with certain antihypertensive medications, such as calcium channel blockers, potentially reducing their effectiveness.
• PHENOXYBENAMINE may also interact with drugs that affect the autonomic nervous system, including anticholinergics and sympathomimetics.

Following are the food interactions for Phenoxybenzamine Capsule:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the breakdown of the medication, leading to increased drug levels in the body.
• Alcohol consumption should be limited or avoided as it may cause excessive drowsiness and dizziness.
• High-sodium foods should be consumed with caution as Phenoxybenzamine can cause sodium retention, potentially leading to increased blood pressure.
• Foods rich in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided. Tyramine can interact with Phenoxybenzamine, leading to a sudden increase in blood pressure.
• Caffeinated beverages like coffee, tea, and energy drinks may exacerbate the medication's side effects, including dizziness and lightheadedness.
• Avoid consuming large amounts of high-fat meals as they may affect the absorption of the medication.
• It is generally recommended to maintain a balanced diet and follow any dietary advice provided by your healthcare professional while taking Phenoxybenzamine.

The proper storage and disposal of PHENOXYBENAMINE capsules are crucial. Store the capsules in a cool, dry area, away from sunlight and moisture, and maintain room temperature. Keep the medication in its original container, tightly sealed, to prevent contamination. Avoid bathrooms or areas near heat sources like stoves, as temperature fluctuations can impact the capsules' effectiveness. Dispose of any unused or expired medication responsibly; do not flush or pour it down the drain. Consult your pharmacist for guidance on safe disposal methods. Ensure the capsules are inaccessible to children to prevent accidental ingestion.

Following are the quick tips for PHENOXYBENAMINE Capsule:

• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Take the capsule as directed by your doctor, usually 3 times a day.
• Maintain a consistent dosing schedule for maximum effectiveness.
• Avoid missing doses; take it regularly for the prescribed duration.
• Inform your doctor if you have any allergies before taking this medication.
• Store in a cool, dry place, away from direct sunlight and moisture.
• Do not share this medication with others, even with similar symptoms.