Difam Plus (75/20mg) 2ml, 5 Ampoule Injections

Diclofenac Sodium and Lignocaine injection work synergistically to provide pain relief. Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), inhibits the production of prostaglandins by blocking cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing inflammation and pain. Lignocaine, a local anesthetic, stabilizes neuronal membranes by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses, leading to local anesthesia and further contributing to pain relief.

Diclofenac Sodium 75mg, Lignocaine

NSAID and Local Anesthetic

injection

The following are the uses of Diclofenac Sodium 75mg, Lignocaine injection:

• Used for relieving acute pain and inflammation caused by various conditions such as postoperative pain, dental pain, or acute musculoskeletal injuries.
• Used for providing local anesthesia, especially during minor surgical procedures, by numbing the area and preventing pain signals from reaching the brain.
• Used for reducing fever and managing symptoms associated with mild to moderate pain and inflammation.
• Used for treating pain and inflammation in conditions like arthritis, providing relief and improving joint mobility.
• Used for controlling pain and inflammation in cases of severe toothache or following dental procedures.
• Used for managing pain and inflammation related to sports injuries, sprains, strains, or other soft tissue injuries.
• Used for providing targeted pain relief during certain medical procedures or diagnostic tests, ensuring patient comfort.

In the case of an overdose of Diclofenac Sodium 75mg and Lignocaine injection, individuals may experience severe side effects. Symptoms can include gastrointestinal issues, such as nausea, vomiting, and stomach pain, as well as potential kidney and liver damage. Additionally, neurological symptoms like dizziness, headaches, and seizures may occur. Immediate medical intervention is necessary, including contacting a healthcare professional or poison control center for guidance on treatment and management.

In the case of a missed dose of Diclofenac Sodium 75mg, it is generally advised to take the missed dose as soon as you remember, provided it is not too close to the next scheduled dose. If it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. For Lignocaine injection, if a dose is missed, it is best to consult your healthcare professional for guidance on whether to administer the missed dose or simply wait for the next scheduled injection.

To administer Diclofenac Sodium 75mg and Lignocaine injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the medication is delivered intramuscularly or intravenously as directed by your healthcare provider, following the recommended dosage and frequency provided.

Following are the conditions or situations when Diclofenac Sodium 75mg and Lignocaine injection should not be used:

• Avoid if allergic to Diclofenac Sodium, Lignocaine, or related non-steroidal anti-inflammatory drugs (NSAIDs).
• Do not use if there is a history of asthma or severe allergic reactions triggered by Aspirin or other NSAIDs.
• Contraindicated in individuals with active or recent gastrointestinal bleeding or perforation.
• Should not be used in patients with severe heart failure or cardiovascular disease.
• Avoid in patients with severe kidney or liver impairment.
• Not recommended during the third trimester of pregnancy or breastfeeding.
• Do not administer if there is a known bleeding disorder or if the patient is taking anticoagulant medication.
• Lignocaine should not be used in patients with a known methemoglobinemia or glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Diclofenac Sodium 75mg and Lignocaine injection may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Skin reactions such as rash, itching, or hives
• Headache or migraine
• Increased blood pressure
• Injection site reactions like pain, swelling, or redness

Following are the precautions and warnings for Diclofenac Sodium 75mg and Lignocaine injection:

• Not recommended for individuals with a known hypersensitivity or allergy to Diclofenac, Lignocaine, or related non-steroidal anti-inflammatory drugs (NSAIDs).
• Patients with a history of gastrointestinal bleeding, ulcers, or other gastrointestinal disorders should use with caution, as this medication may increase the risk of gastrointestinal complications.
• May cause liver and kidney damage; regular monitoring of liver and kidney function is advised, especially during long-term use.
• Should be used with caution in individuals with cardiovascular disease, hypertension, or a history of stroke, as it may increase the risk of cardiovascular events.
• Not recommended for pregnant women, especially during the third trimester, as it may cause complications. Breastfeeding women should also consult a healthcare professional before use.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• May cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Lignocaine may cause severe allergic reactions, including anaphylaxis; emergency medical attention should be sought if any symptoms occur.

Following are the drug interactions for Diclofenac Sodium 75mg and Lignocaine Injection:

• Diclofenac may increase the risk of bleeding when taken with anticoagulants (e.g., warfarin, heparin) and antiplatelet drugs (e.g., aspirin, clopidogrel).
• It can reduce the effectiveness of antihypertensive medications, including beta-blockers, ACE inhibitors, and diuretics.
• The risk of kidney damage may increase when combined with other nephrotoxic drugs, such as cyclosporine or aminoglycosides.
• Lignocaine may interact with other local anesthetics, resulting in increased toxicity.
• It can also interact with drugs that affect the liver, such as antiepileptic medications, potentially altering lignocaine metabolism.
• The use of Lignocaine with other vasopressor agents may lead to excessive hypertension.
• Diclofenac can increase plasma concentrations of lithium and methotrexate, requiring close monitoring.

Following are the food interactions for Diclofenac Sodium 75mg and Lignocaine injection:

• Avoid excessive alcohol consumption while using Diclofenac as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Diclofenac, potentially leading to increased blood levels and side effects.
• Maintain a balanced diet, as Diclofenac can sometimes cause sodium and fluid retention.
• Lignocaine may cause temporary numbness or altered taste sensation, so it is advisable to avoid hot or spicy foods immediately after the injection.
• Caffeine-rich beverages like coffee and tea may interact with Lignocaine, potentially affecting its metabolism and increasing side effects.
• Avoid eating or drinking immediately after Lignocaine injection to prevent choking or aspiration.
• Ensure adequate hydration before and after the injection to minimize discomfort and improve the effectiveness of Lignocaine.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition and medication regimen.

Diclofenac Sodium 75mg and Lignocaine injection should be stored in a controlled environment, away from direct sunlight and moisture. It is recommended to keep the medication in its original packaging, tightly sealed, to maintain its integrity. The ideal storage temperature is between 68°F and 77°F (20°C and 25°C), ensuring the medication remains stable. Avoid freezing or exposing the medication to excessive heat. Always check the expiration date before use, and properly dispose of any unused or expired medication. Do not dispose of it in household garbage or pour it down the drain; consult your pharmacist or healthcare provider for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Diclofenac Sodium 75mg and Lignocaine Injection:

• Consult a doctor for proper prescription and dosage instructions.
• Ensure the injection is administered by a trained medical professional.
• Inform your doctor about any allergies or ongoing medications.
• Do not reuse needles or syringes; dispose of them safely.
• Store the injection at room temperature, away from direct sunlight.
• Report any unusual side effects or severe reactions immediately.
• Do not self-inject; seek medical supervision for safe administration.
• Keep a record of injection sites to alternate and prevent tissue damage.