DIFLUCAN INJ 50ML

DIFLUCAN INJ 50ML

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  • Manufacturer PFIZER LABORATORIES LTD
  • Generic Name

    Fluconazole 50mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Fluconazole 50mg Injection, a potent antifungal medication, exerts its action by specifically inhibiting the fungal enzyme lanosterol 14-alpha-demethylase. This enzyme plays a critical role in the biosynthesis of ergosterol, a vital component of fungal cell membranes. By blocking this enzyme, fluconazole disrupts the formation of ergosterol, leading to impaired membrane integrity and function in fungal cells. This disruption ultimately results in the inhibition of fungal growth and replication, making fluconazole highly effective against a range of fungal infections, particularly those caused by Candida species.

  • Ingredients

    Fluconazole 50mg

  • Drug Class

    Antifungal, triazole derivative.

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Fluconazole 50mg Injection:

    • Used for treating serious fungal infections that may be life-threatening, such as systemic candidiasis.
    • Used for managing fungal infections in patients with weakened immune systems.
    • Used for controlling fungal infections in specific organs or body systems.
    • Used for treating fungal peritonitis, a condition affecting the abdominal lining.
    • Used for managing fungal infections in patients undergoing cancer treatment.
    • Used for preventing and controlling fungal infections in high-risk patients.
    • Used for treating persistent or recurrent fungal infections.
    • Used for its broad-spectrum antifungal properties in various medical scenarios.
  • In case of Overdose

    In the case of an overdose of Fluconazole 50mg Injection, symptoms may include hallucinations, seizures, severe nausea, and vomiting. It is important to recognize that an overdose can lead to serious health complications. If an overdose is suspected, immediate medical intervention is necessary. The patient should be monitored closely for any adverse reactions, and supportive care should be provided to manage symptoms and ensure the patient's well-being. Prompt action can help mitigate the risks associated with Fluconazole overdose.

  • Missed Dose

    In the case of a missed dose of Fluconazole 50mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is recommended to store the medication at room temperature and away from light to maintain its effectiveness.

  • How To Use

    To administer Fluconazole 50mg Injection, follow the instructions provided by your healthcare professional; inject the entire content of the vial intramuscularly or intravenously, ensuring proper aseptic technique and under medical supervision.

  • When Not to Use

    Here are the conditions or situations when Fluconazole 50mg Injection should not be used:

    • Avoid using if you have a known allergy to Fluconazole or other azole antifungal medications.
    • Not recommended for patients with a history of liver disease or impaired liver function.
    • Contraindicated in patients with a rare hereditary condition called acute porphyria.
    • Should not be used to treat fungal infections that are not proven or suspected.
    • Avoid using if you have a history of heart conditions, such as QT prolongation or heart rhythm disorders.
    • Not suitable for patients with a history of severe skin reactions to other antifungal medications.
    • Should not be used if you are taking certain medications that may interact with Fluconazole, such as cisapride, pimozide, or certain types of antidepressants.
    • Contraindicated in patients with a history of hypersensitivity reactions to other azole antifungal agents.
    • Not recommended for individuals with severe kidney problems without adjusting the dosage.
  • Side Effects

    The side effects of Fluconazole 50mg Injection may include:

    • Nausea and vomiting
    • Diarrhea
    • Abdominal pain
    • Headache
    • Dizziness
    • Skin rashes or itching
    • Increased liver enzymes (detected in blood tests)
    • Allergic reactions (rare)
  • Precautions & Warnings

    Following are the precautions and warnings for Fluconazole 50mg Injection:

    • Do not use if you have a known allergy to Fluconazole or other azole antifungal medications. Allergic reactions can be severe and immediate medical attention should be sought if symptoms occur.
    • Regular monitoring of liver function is necessary during prolonged treatment, especially in patients with pre-existing liver conditions. Fluconazole can cause liver enzyme elevations.
    • Use with caution in patients with pre-existing heart conditions. Fluconazole may cause QT interval prolongation, which can lead to serious cardiac arrhythmias.
    • Inform your healthcare provider about all medications you are taking, as Fluconazole can interact with various drugs, including warfarin, phenytoin, and oral contraceptives.
    • Pregnant and breastfeeding women should use Fluconazole with caution and only if the potential benefits outweigh the risks. It may harm the developing fetus or infant.
    • Fluconazole can cause electrolyte abnormalities, especially in patients with pre-existing conditions. Regular monitoring of potassium and magnesium levels is recommended.
    • Discontinue use and seek medical advice if you develop a severe skin reaction, including Stevens-Johnson syndrome or toxic epidermal necrolysis.
  • Drug Interactions

    Following are the drug interactions for Fluconazole 50mg Injection:

    • Co-administration with cisapride, pimozide, or quinidine can lead to serious cardiac arrhythmias and is contraindicated.
    • Concomitant use with warfarin may potentiate the anticoagulant effect, requiring close monitoring of prothrombin time.
    • Fluconazole can increase plasma concentrations of statins, leading to an increased risk of myopathy and rhabdomyolysis.
    • The combination with HMG-CoA reductase inhibitors (e.g., simvastatin, atorvastatin) may result in elevated liver enzymes and require dose adjustments.
    • Drugs metabolized by CYP3A4, such as cyclosporine, tacrolimus, and phenytoin, may have elevated levels when used with fluconazole, necessitating dosage reduction.
    • Anticonvulsants like phenytoin and valproic acid may have decreased efficacy when used concurrently with fluconazole.
    • Fluconazole may increase the toxicity of hydrochlorothiazide and other diuretics, requiring careful monitoring of electrolyte levels.
  • Food Interactions

    Following are the food interactions for Fluconazole 50mg Injection:

    • Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the levels of Fluconazole in the blood, leading to potential toxicity.
    • Alcohol intake is not recommended during treatment with Fluconazole as it may increase the risk of liver-related side effects and may also enhance the sedative effects of the medication.
    • Avoid high-fat meals as they can slightly delay the absorption of Fluconazole, although this does not significantly affect its overall effectiveness.
    • Cranberry juice and cranberry products may decrease the effectiveness of Fluconazole, so it's best to limit their consumption during treatment.
    • Foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be avoided as Fluconazole can inhibit the breakdown of tyramine, leading to a potential increase in blood pressure.
    • Limit caffeine intake as Fluconazole may slow down its metabolism, prolonging its effects and potentially increasing the risk of caffeine-related side effects.
    • No specific food restrictions are necessary for Fluconazole, but maintaining a balanced diet is generally advised.
    • Always consult your healthcare provider for personalized advice on food and medication interactions.
  • Storage/Disposal

    Fluconazole 50mg Injection should be stored in a controlled environment, preferably in a cool and dry place with a temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from direct sunlight, moisture, and heat, as these factors can degrade its potency. Keep the medication in its original packaging, ensuring the container is tightly sealed to maintain sterility. Always check the expiration date before use and discard any expired or unused injections according to local regulations. Do not dispose of the medication by flushing it or pouring it down the drain; instead, contact your pharmacist or healthcare provider for guidance on proper disposal methods to minimize environmental impact. Keep the injection out of the reach of children and pets to prevent accidental exposure or ingestion.

  • Quick Tips, if any

    Following are the quick tips for Fluconazole 50mg Injection:

    • Ensure the injection is administered by a trained healthcare professional.
    • Confirm your allergy status before injection to avoid adverse reactions.
    • Inform your doctor of all medications you're taking to prevent drug interactions.
    • Remain hydrated and drink plenty of fluids before and after the injection.
    • Report any persistent or severe side effects to your doctor immediately.
    • Do not reuse or share needles to prevent infections.
    • Store the injection as directed on the label, away from direct sunlight.

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