Co-Diovan (160/25mg) 14 Tablets

Hydrochlorothiazide and Valsartan work together in this combination medication to lower blood pressure. Hydrochlorothiazide is a diuretic that increases urine production, helping to reduce fluid volume and blood pressure by inhibiting the reabsorption of sodium and chloride ions in the distal tubule of the kidney. This leads to increased excretion of water and electrolytes, resulting in a decrease in blood volume and, consequently, blood pressure. Valsartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II hormone from binding to its receptors, preventing the hormone's vasoconstrictive effects. This action promotes vasodilation, which reduces peripheral resistance and lowers blood pressure. By combining these two mechanisms, the tablet effectively lowers blood pressure and helps manage hypertension.

Hydrochlorothiazide 25mg, Valsartan 160mg

Angiotensin II Receptor Blocker, Thiazide Diuretic

Tablet

The following are the uses of Hydrochlorothiazide 25mg, Valsartan 160mg Tablet:

• Used for treating high blood pressure (hypertension).
• Used to lower blood pressure and reduce the risk of heart disease and stroke.
• Used to manage fluid retention (edema) in conditions like heart failure.
• Used to improve blood flow and reduce strain on the heart.
• Used for controlling blood pressure in patients with diabetes or kidney problems.
• Used to prevent kidney damage and slow the progression of kidney disease.
• Used to improve overall cardiovascular health and quality of life.
• Used in combination with other medications for comprehensive blood pressure management.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Valsartan 160mg-
• High blood pressure (hypertension)• Usual starting dose is 160mg once a day. Maximum dose is 640mg per day.
• Congestive heart failure (CHF)• Start at 80mg and may increase to 320mg depending on tolerance. Often given in combination with other drugs.
• Treatment of strokes and aortic stenosis• Same as hypertension dosage
• Hydrochlorothiazide 25mg-
• High blood pressure (hypertension)• Initial dose of 25mg once a day. May increase to 50mg per day.
• Congestive heart failure (CHF)• Used in combination with Valsartan or with other drugs.
• renal disease• Used in combination with other drugs.

In the case of an overdose of Hydrochlorothiazide 25mg and Valsartan 160mg Tablets, symptoms may include excessive urination, dizziness, and a rapid decrease in blood pressure. It is important to recognize that this combination can lead to severe dehydration and electrolyte imbalances, especially with excessive urination. If an overdose is suspected, prompt medical attention is necessary, and healthcare professionals should be contacted immediately to provide appropriate treatment and monitoring.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. For Valsartan 160mg, if a dose is missed, take it as soon as you remember, but if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Hydrochlorothiazide 25mg, Valsartan 160mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the instructions provided by your healthcare professional.

Here are the conditions and situations when Hydrochlorothiazide 25mg, Valsartan 160mg Tablet should not be taken:

• Do not take if you are allergic to hydrochlorothiazide, valsartan, or any other similar medications (such as sulfonamide-derived drugs).
• Avoid if you have a history of angioedema (swelling of the face, lips, tongue, or throat) with or without previous exposure to these types of medications.
• Should not be used in individuals with severe kidney disease or those with a history of kidney problems.
• Contraindicated in individuals with severe liver disease or biliary obstruction (blockage in the bile ducts).
• Do not use if you are pregnant or planning to become pregnant, as this medication can cause harm to the fetus.
• Not recommended for breastfeeding mothers, as it may pass into breast milk.
• Avoid if you have a history of low blood pressure (hypotension) or conditions that may cause low blood pressure.
• Should not be used in individuals with a history of high potassium levels (hyperkalemia) or conditions that may cause high potassium levels.
• Contraindicated in individuals with a rare condition called renal artery stenosis (narrowing of the arteries supplying the kidneys).
• Do not use if you have a history of or are currently experiencing severe dehydration or electrolyte imbalances.
• Avoid if you have a history of systemic lupus erythematosus (SLE) as it may worsen the condition.

The side effects of Hydrochlorothiazide 25mg, Valsartan 160mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rashes or itching
• Muscle cramps or joint pain
• Decreased blood pressure (hypotension)

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Valsartan 160mg Tablet:

• Not suitable for individuals with known allergies to hydrochlorothiazide, valsartan, or related medications.
• Patients with a history of kidney or liver problems should use with caution, as monitoring and dosage adjustments may be necessary.
• Elderly patients may be more susceptible to side effects, particularly dizziness and lightheadedness.
• May cause an increased sensitivity to the sun; limit sun exposure and use protective measures.
• Avoid potassium supplements and potassium-rich foods without medical advice, as this medication can increase potassium levels.
• Inform your doctor if you have diabetes, as this medication may affect blood sugar levels.
• Not recommended during pregnancy or breastfeeding unless advised by a healthcare professional.
• Patients with a history of angioedema should use with caution, as this medication may increase the risk of this condition.

Following are the drug interactions for Hydrochlorothiazide 25mg, Valsartan 160mg Tablet:

• Lithium levels may be increased, leading to lithium toxicity. Close monitoring of lithium levels is recommended.
• The hypotensive effects of Hydrochlorothiazide can be reduced by NSAIDs.
• May decrease the elimination of calcium channel blockers, increasing the risk of side effects.
• Potassium-sparing diuretics like spironolactone or eplerenone may lead to hyperkalemia when used with Valsartan.
• The antihypertensive effect of Valsartan may be reduced by NSAIDs.
• Valsartan's levels may be increased by CYP2C9 inhibitors, potentially leading to more side effects.
• Rifampin, a CYP2C9 inducer, may decrease the effectiveness of Valsartan.

Following are the food interactions for Hydrochlorothiazide 25mg and Valsartan 160mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may increase blood levels of Valsartan, potentially affecting blood pressure control.
• Alcohol may increase the blood pressure-lowering effect of Hydrochlorothiazide, and excessive alcohol consumption can reduce the effectiveness of Valsartan.
• Avoid excessive salt (sodium) intake, as Hydrochlorothiazide is a diuretic and can lead to increased sodium loss.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial, as Hydrochlorothiazide may cause potassium loss.
• Valsartan may increase potassium levels, so be cautious with high-potassium foods, especially if you have kidney issues.
• Avoid licorice, as it can decrease the effectiveness of Valsartan by reducing potassium levels.
• Maintain a balanced diet, as Hydrochlorothiazide may affect blood sugar levels, and Valsartan may impact kidney function.
• Always consult your healthcare provider for personalized dietary advice while taking these medications.

Hydrochlorothiazide 25mg, Valsartan 160mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to store the tablets, maintaining their integrity and preventing contamination. It is crucial to keep the medication away from heat sources like radiators or ovens, as extreme temperatures can impact its effectiveness. Prioritize checking the expiration date regularly, and if the tablets have expired or are no longer needed, proper disposal is essential. Instead of flushing or pouring them down the drain, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Always store medications securely, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 25mg and Valsartan 160mg Tablet:

• Consult your doctor or pharmacist for personalized advice before starting the medication.
• Take the tablet as directed, usually once daily, at the same time each day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent fluid intake while taking this medication.
• Inform your doctor if you have a history of kidney or liver problems.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Do not use potassium supplements or salt substitutes without medical advice.

Valsartan (160mg) and Hydrochlorothiazide (25mg) are a popular combination drug used to treat high blood pressure. These drugs work in a complementary fashion to effectively reduce blood pressure in patients. While this medication is generally safe, it is important to monitor health while taking these drugs and ensure that they are working effectively and not causing any adverse effects. Tests are required to monitor health and should be conducted periodically as follows: