DIPIP 15/120 SACHETS

Dihydroartemisinin (DHA) and Piperaquine Phosphate are the active components in the combination treatment. DHA, derived from artemisinin, exerts its antimalarial effect by reacting with malarial parasite's endoperoxide, which results in the generation of free radicals. These free radicals then damage the parasite's proteins and lipids, ultimately leading to parasite death. Piperaquine, on the other hand, belongs to the bisquinoline class of drugs and acts by interfering with the parasite's DNA replication and transcription processes, thereby inhibiting the growth and replication of the malaria parasites, particularly effective against the blood stages of the parasite. This dual mechanism of action makes the combination a powerful tool in treating malaria, especially in regions where resistance to other antimalarial drugs is prevalent.

Antimalarial

Oral

The following are the uses of Dihydroartemisinin, Piperaquine Phosphate Sachet:

• Used for treating uncomplicated Plasmodium falciparum malaria.
• Used to target the malaria parasite's ability to multiply.
• Used to clear the parasite from the patient's blood.
• Used as a combination therapy for better efficacy against drug-resistant malaria strains.
• Used to reduce fever and improve symptoms related to malaria.
• Used as a preventive measure for travelers visiting malaria-endemic regions.
• Used in accordance with local malaria treatment guidelines and recommendations.

In the case of an overdose of Dihydroartemisinin and Piperaquine Phosphate, prompt medical attention is necessary. Symptoms may include severe nausea, vomiting, and dizziness. Medical professionals should be informed about the specific drug combination and dosage to provide appropriate treatment. Quick action can help mitigate potential adverse effects and ensure the patient's safety. It is crucial to seek medical assistance immediately and provide relevant information to healthcare providers.

In the case of a missed dose of Dihydroartemisinin and Piperaquine Phosphate Sachet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the treatment or adjust the dosing schedule accordingly.

To take Dihydroartemisinin, Piperaquine Phosphate Sachet, empty the contents of the sachet into a glass of water, stir well until the powder is fully dissolved, and drink the entire mixture immediately, following the prescribed dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Dihydroartemisinin, Piperaquine Phosphate Sachet should not be used:

• Not recommended for individuals with a known allergy to Dihydroartemisinin, Piperaquine Phosphate, or any other related compounds.
• Contraindicated in patients with a history of prolonged QT interval or other heart rhythm disorders.
• Should not be used in patients with severe liver or kidney disease.
• Not suitable for individuals who are also taking certain medications, such as CYP3A4 inhibitors or inducers, as this may affect drug metabolism.
• Avoid in patients with known prolonged QT interval syndromes or family history of such conditions.
• Do not use in patients with a history of severe allergic reactions to other antimalarial drugs.
• Contraindicated in patients with known glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Dihydroartemisinin and Piperaquine Phosphate Sachet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain or discomfort
• Dizziness
• Headache
• Loss of appetite
• Skin rashes or itching
• Muscle or joint pain

Following are the precautions and warnings for Dihydroartemisinin, Piperaquine Phosphate Sachet:

• This medication is intended for the treatment of malaria and should not be used for any other conditions without medical supervision.
• Do not take this medication if you have a known allergy to Dihydroartemisinin or Piperaquine Phosphate, or any other related compounds.
• Patients with underlying liver or kidney disease should use this medication with caution and under medical supervision as it may require dosage adjustments.
• Avoid driving or operating heavy machinery if you experience dizziness, blurred vision, or any other side effects that affect your ability to concentrate.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the use of this medication in these situations requires careful monitoring.
• Children should only be given this medication under strict medical supervision, and the dosage should be adjusted according to their weight.
• Complete the full course of treatment as prescribed, even if symptoms improve, to ensure the parasite is completely eliminated from the body.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for Dihydroartemisinin, Piperaquine Phosphate Sachet:

• Co-administration with other antimalarial drugs like chloroquine or mefloquine may reduce the effectiveness of Piperaquine due to potential drug-drug interactions.
• Piperaquine can increase plasma concentrations of simvastatin and other statins, potentially increasing the risk of myopathy and rhabdomyolysis.
• Concomitant use with rifampicin, a strong CYP3A4 inducer, may decrease the effectiveness of Piperaquine.
• The effectiveness of Piperaquine may be reduced when taken with antacids containing aluminum or magnesium, as they can decrease its absorption.
• Dihydroartemisinin may increase the risk of bleeding when used with anticoagulants or antiplatelet drugs.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, should be used cautiously with Piperaquine due to potential cardiac effects.
• Piperaquine may interact with hormonal contraceptives, potentially reducing their effectiveness, and alternative birth control methods are recommended.

Following are the food interactions for Dihydroartemisinin, Piperaquine Phosphate Sachet:

• This medication should be taken with food, preferably a meal containing some fat, to enhance the absorption of Piperaquine.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Piperaquine, potentially leading to increased drug levels and a higher risk of side effects.
• Alcohol may not directly interact with the medication, but it's generally recommended to avoid excessive alcohol consumption during treatment to ensure optimal recovery and prevent potential liver issues.
• Fatty foods can be beneficial as they aid in the absorption of Piperaquine, ensuring better effectiveness of the treatment.
• Dairy products, especially milk, might reduce the absorption of the medication, so it's best to separate them by a few hours.
• Vitamin C-rich foods, like citrus fruits, may enhance iron absorption, which can be beneficial as Dihydroartemisinin may lead to a temporary decrease in iron levels.
• Caffeine intake should be monitored as it may enhance the effects of the medication on the heart, potentially causing irregular heartbeats.
• A balanced diet is essential during treatment to support overall health and recovery.

Dihydroartemisinin, Piperaquine Phosphate Sachet should be stored in a secure and dry location, preferably in its original packaging, to maintain its integrity and effectiveness. Keep it away from direct sunlight, moisture, and extreme temperatures, as heat and humidity can degrade the medication. Always check the expiration date, and if the sachet is past its expiry, do not use it and dispose of it properly. For disposal, do not throw it into the trash or flush it down the toilet; instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment. Keep this medication out of children's reach to prevent accidental consumption, and ensure that it is stored in a safe and locked cabinet.

Following are the quick tips for Dihydroartemisinin, Piperaquine Phosphate Sachet:

• Always take the medication as directed by your doctor or healthcare provider.
• Ensure you understand the dosage instructions, especially if taking multiple sachets.
• Take the medication with a full glass of water to aid in swallowing and absorption.
• Do not crush or chew the contents of the sachet; swallow them whole.
• Maintain a consistent schedule for taking the medication for best results.
• Store the sachets in a cool, dry place, away from direct sunlight and moisture.
• If you experience any adverse effects, contact your healthcare provider immediately.
• Do not share your medication with others, even if they have similar symptoms.