Dipip (40/320mg) 8 Capsules

Dihydroartemisinin and Piperaquine Phosphate are the active components in the combination therapy. Dihydroartemisinin, derived from artemisinin, exerts its antimalarial effect by reacting with malarial parasite biomolecules, generating free radicals that damage the parasite's proteins, membranes, and DNA. This process specifically targets the parasite's intraerythrocytic forms. On the other hand, Piperaquine Phosphate, a bisquinoline, interferes with the parasite's nucleic acid and protein synthesis, leading to the disruption of vital cellular processes and ultimately eliminating the parasite. This dual mechanism of action effectively combats malaria by attacking different stages of the parasite's life cycle.

Antimalarial combination.

Capsule

The following are the uses of Dihydroartemisinin, Piperaquine Phosphate Capsule:

• Used for treating malaria, including chloroquine-resistant strains.
• Used to combat Plasmodium falciparum and Plasmodium vivax parasites.
• Used to prevent and manage severe malaria cases, reducing parasite load.
• Used as a combination therapy for enhanced effectiveness and delayed resistance.
• Used for its fast-acting properties, quickly reducing fever and symptoms.
• Used in regions with high malaria prevalence for improved patient outcomes.
• Used under medical supervision, with dosage based on patient weight and severity.
• Used as a key component in malaria control and elimination strategies.

In the case of an overdose of Dihydroartemisinin and Piperaquine Phosphate Capsules, symptoms may include an increase in the severity of common side effects such as nausea, vomiting, and dizziness. More severe effects could include a prolonged QT interval, which may lead to an irregular heartbeat. Prompt medical attention is necessary, including contacting a healthcare professional or poison control center for guidance on managing the overdose. Quick action can help prevent potential complications.

In the case of a missed dose of Dihydroartemisinin and Piperaquine Phosphate Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. It is important to maintain a consistent dosing routine, but if you frequently miss doses, consult your healthcare provider for guidance on how to adjust your medication schedule.

To take Dihydroartemisinin, Piperaquine Phosphate Capsule, swallow the capsule whole with water, preferably after a meal, following the dosage instructions provided by your healthcare provider, typically once a week for three consecutive weeks, as directed.

Following are the conditions/situations when Dihydroartemisinin, Piperaquine Phosphate Capsule should not be taken:

• Do not take if you have a known allergy to artemisinin-based compounds or piperaquine, or any other ingredients in the capsule.
• Contraindicated in patients with a history of prolonged QT interval or other cardiac disorders.
• Avoid using if you have severe liver or kidney impairment.
• Not suitable for individuals with a known deficiency of G6PD (glucose-6-phosphate dehydrogenase).
• Should not be used in pregnant or breastfeeding women.
• Avoid in patients with a history of seizures or epilepsy.
• Do not administer to children under a certain weight or age (as specified by a healthcare professional).
• Contraindicated in individuals with known hypersensitivity to similar antimalarial drugs.
• Not recommended for patients with severe gastrointestinal disorders or a history of gastrointestinal bleeding.

Here are the possible side effects of Dihydroartemisinin and Piperaquine Phosphate Capsule:

• Headache
• Dizziness
• Nausea or vomiting
• Abdominal pain
• Diarrhea
• Loss of appetite
• Weakness or fatigue
• Insomnia
• Palpitations or irregular heartbeat
• Allergic reactions, such as rash or itching

Following are the precautions and warnings for Dihydroartemisinin, Piperaquine Phosphate Capsule:

• This medication is intended for the treatment of malaria and should only be used as directed by a healthcare professional. Do not self-medicate.
• Patients with known allergies to artemisinin derivatives or piperaquine should not take this medication.
• Caution is advised for patients with underlying liver or kidney disease, as these conditions may affect drug metabolism.
• Regular monitoring of liver and kidney function is recommended during treatment.
• Dihydroartemisinin, Piperaquine Phosphate Capsule may cause dizziness or blurred vision. Avoid driving or operating machinery until you know how this medicine affects you.
• Patients should complete the full course of treatment as prescribed, even if symptoms improve, to ensure complete eradication of the parasite.
• Inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.
• Store the medication in a cool, dry place, away from direct sunlight and moisture, and keep out of reach of children.

Following are the drug interactions for Dihydroartemisinin, Piperaquine Phosphate Capsule:

• Concomitant use with other antimalarial drugs, such as mefloquine or chloroquine, may result in reduced effectiveness due to potential resistance.
• Piperaquine can increase plasma concentrations of digoxin, requiring close monitoring of digoxin levels.
• The capsule may decrease the effectiveness of oral contraceptives, so alternative contraceptive methods should be considered.
• Drugs that prolong the QT interval, such as certain antiarrhythmic medications, should be used cautiously due to the potential for QT prolongation.
• Rifampicin can reduce the plasma concentrations of piperaquine, possibly leading to treatment failure.
• Dihydroartemisinin may increase the risk of bleeding when taken with anticoagulants, and close monitoring is necessary.
• It can also interact with antiretroviral drugs used for HIV treatment, potentially affecting the efficacy of both medications.
• Caution is advised when combining with drugs that induce or inhibit CYP3A4 enzymes, as it may alter the metabolism of dihydroartemisinin and piperaquine.

Following are the food interactions for Dihydroartemisinin, Piperaquine Phosphate Capsule:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Piperaquine, potentially increasing its levels in the blood and altering its effectiveness.
• Fatty meals can decrease the absorption of Piperaquine, so it is best to avoid high-fat foods before and after taking the medication to ensure optimal absorption.
• Alcohol consumption should be minimized or avoided as it may increase the risk of side effects such as dizziness, drowsiness, and gastrointestinal discomfort.
• Avoid caffeine-rich beverages like coffee and energy drinks, as they may exacerbate potential side effects like insomnia and nervousness.
• There is no known interaction with dairy products, but if you have lactose intolerance or dairy sensitivity, consider taking the medication with non-dairy alternatives.
• Avoid excessive salt intake, as Piperaquine may interact with sodium levels in the body, and high salt consumption might affect its effectiveness.
• Consuming a balanced diet with adequate hydration is generally recommended to support overall health during the medication course.

Dihydroartemisinin, Piperaquine Phosphate Capsule storage and disposal guidelines are crucial for maintaining safety and effectiveness. Store the capsules in a cool, dry place, preferably at room temperature, away from sunlight and moisture. Keep the medication in its original container, tightly sealed, to prevent contamination. Avoid exposure to heat or cold, and never store it in the bathroom or kitchen due to temperature fluctuations. Dispose of any unused or expired capsules responsibly; do not flush them or pour them down the drain. Contact your pharmacist or healthcare provider for guidance on proper disposal methods. Keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Dihydroartemisinin, Piperaquine Phosphate Capsule:

• Take the capsule as directed by your doctor to ensure effectiveness.
• Consume the capsule with a full glass of water for easy swallowing.
• Maintain a consistent schedule by taking the medication at the same time daily.
• Consider taking the capsule with food to prevent nausea.
• Avoid cutting or crushing the capsule; swallow it whole.
• Do not share your medication with others, even if they have similar symptoms.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.