Disprin (300mg) 600 Tablets

Aspirin works by blocking an enzyme called cyclooxygenase (COX), which plays a key role in producing substances in the body called prostaglandins. Prostaglandins are involved in pain, inflammation, and blood clotting. Aspirin stops the production of prostaglandins, which reduces pain and swelling in the body.Aspirin also prevents platelets (cells involved in blood clotting) from clumping together by blocking prostaglandin production. This "blood-thinning" effect helps prevent blood clots, which can lead to heart attacks and strokes.

Nonsteroidal Anti-Inflammatory Drug (NSAID)

This medication is used for:

• Pain Relief
• Fever
• Inflammation
• Cardiovascular Prevention

Aspirin dosage recommendations are:

• Thrombosis - 75-150 mg once daily. Doses up to 300 mg daily may be necessary for some circumstances.
• Fever, Pain - 300-900 mg 4-6 hourly as required. Max - 4,000 mg daily.
• Myocardial infarction - Initial treatment - Loading dose - 150-300 mg.

In the event of an overdose or early poisoning with aspirin, symptoms may include burning in the mouth, lethargy, nausea, vomiting, tinnitus, sweating, thirst, tachycardia, or dizziness. A moderate overdose presents with additional symptoms such as tachypnea, hyperpyrexia, dehydration, loss of coordination, restlessness, and mental confusion. In severe cases, symptoms escalate to include hypotension, hallucinations, stupor, hypoglycemia, convulsions, cerebral edema, oliguria, renal failure, cardiovascular failure, coma, hemorrhage, metabolic acidosis, and/or respiratory failure. Emergency management involves immediate hospital transfer, where cardiovascular and respiratory support must be maintained. Treatment includes gastric lavage and the administration of activated charcoal, with close monitoring and correction of acid-base imbalances if necessary. Alkaline diuresis should be considered when plasma salicylate concentrations exceed 500 mg/L in adults or 300 mg/L in children. Hemodialysis may be required in severe cases where salicylate levels are above 800 mg/L in adults or 700 mg/L in children, or if there are significant systemic symptoms such as severe metabolic acidosis, acute renal failure, pulmonary edema, or central nervous system issues like drowsiness, agitation, coma, or convulsions. Fluid losses should be replaced with a hypotonic solution, such as half saline, supplemented with glucose. Symptomatic treatment should be provided as needed. Fatal doses of aspirin range from 10 to 30 grams, though there have been cases where up to 130 grams were ingested without a fatal outcome. For suspected overdose, contact the regional Poison Control Centre immediately.

Take the missed dose as soon as you remember. If it’s close to the next dose, skip the missed dose. Do not take two doses together.

Take tablet with a full glass of water. Follow the dosage instructions provided by your healthcare provider.

Do not use aspirin:

• If you are hypersensitive to ASA, salicylates, non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, antipyretics, or any other ingredients in the product.
• If you have an acute gastrointestinal ulcer or a history of gastrointestinal ulcers.
• If you have hemorrhagic diathesis.
• If you have active or severe hepatic failure, renal failure, or congestive heart failure.
• If you have a history of asthma induced by salicylates or substances with similar actions, notably NSAIDs.
• If you are combining with methotrexate at doses of 15 mg/week or more.
• If you are in the last trimester of pregnancy.

Unraveling the side effects lurking behind this drug product are the following:

• Abdominal pain
• Heartburn
• Indigestion
• Yellow-colored eyes or skin
• Skin rash
• Irregular heartbeat
• Acid or sour stomach
• Drowsiness
• Irritability
• Nausea and vomiting
• Stomach upset
• Unexplained tiredness
• Easy bruising and bleeding

Patients should be aware of these precautions and warnings:

• Avoid use if you have allergic disease, asthma, chronic respiratory disease, anemia, less severe cardiac failure, SLE, connective tissue disorders, thyrotoxicosis, hypertension, G6PD deficiency, or risk factors for peptic ulcer disease (e.g., alcoholism, smoking).
• Not recommended for use during menorrhagia and avoid use for 6 weeks following varicella vaccination.
• May mask signs and symptoms of infection.
• Use with caution if undergoing surgical procedures, including tooth extraction.
• Avoid concomitant use with anticoagulants (e.g., warfarin), thrombolytics, other antiplatelet agents, SSRIs, and oral corticosteroids, as well as other NSAIDs.
• Use with caution in dehydrated and debilitated patients, those with mild to moderate renal and hepatic impairment, and the elderly.
• Avoid use during pregnancy, especially in the 1st and 2nd trimesters.

Drug interactions with aspirin include:

• Anticoagulants (e.g., warfarin) (increased risk of bleeding)
• Non-steroidal anti-inflammatory drugs (NSAIDs) (additive risk of gastrointestinal bleeding)
• Antihypertensives (e.g., ACE inhibitors, diuretics) (may reduce effectiveness of antihypertensives)
• Methotrexate (increased risk of methotrexate toxicity)
• Lithium (increased risk of lithium toxicity)
• Corticosteroids (increased risk of gastrointestinal side effects)
• Alcohol (increased risk of gastrointestinal bleeding)
• Selective serotonin reuptake inhibitors (SSRIs) (increased risk of bleeding)
• Probenecid (may decrease the effectiveness of aspirin)
• Other anticoagulants (e.g., heparin) (increased risk of bleeding)

The food interactions that should be considered while using Aspirin are:

• Increased risk of gastrointestinal bleeding with alcohol.
• Decreased rate but not the extent of absorption with food.

Aspirin should be stored properly to maintain its effectiveness. Store the product at a temperature between 15°C and 30°C in a cool, dry place, away from direct heat, light, and moisture. Ensure the container is tightly closed to prevent contamination. For safety purposes, keep aspirin out of reach of children and pets to avoid accidental ingestion. It is advisable to avoid storing the product in humid or warm areas, such as bathrooms or kitchens. If you have any questions or concerns about proper storage, consult your doctor or pharmacist for further guidance to ensure the product’s quality and safety.