Distalgesic (37.5/325mg) 10 Tablets

Distalgesic (37.5/325mg) 10 Tablets

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  • Manufacturer ATCO Laboratories (Pvt.) Ltd.
  • Generic Name Paracetamol, Tramadol

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Storage/Disposal
  • Description

    Tramadol HCl 37.5mg and Paracetamol 325mg is a powerful combo analgesic, used to relieve severe pain. Tramadol HCl works by binding to and activating mu-opioid receptors in the central nervous system (CNS). It also acts as an agonist for serotonin and norepinephrine receptors, which contributes to its pain-relieving effects. Paracetamol works by inhibiting the production of prostaglandins, which are hormone-like substances that contribute to pain and inflammation. By reducing prostaglandin levels, paracetamol aids in pain relief. The combination of these two analgesics targets different pathways involved in pain perception and inflammation, making this medication effective in relieving moderate to severe pain. The exact mechanism of action is not fully understood, but it is thought that tramadol's interaction with multiple receptors in the CNS helps to regulate pain perception and alleviate discomfort. Paracetamol's activation of serotonin release in the brain also contributes to its analgesic effects. The HCl component of Tramadol serves as a solubilizing agent, helping to dissolve tramadol in solution for oral administration. Together, the mechanisms of both drugs work in tandem to relieve severe pain.

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  • Ingredients

    Paracetamol, Tramadol
  • Drug Class

    Analgesic, Opioid Analgesic

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  • Dosage Form

    Tablet

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  • Uses

    Unveiling its multifaceted uses and transformative applications as follows:

    • Used to relieve moderate to severe pain
    • Tramadol HCl is an opioid pain reliever that works by blocking the transmission of pain signals from the brain to the body, Paracetamol, on the other hand, is an analgesic (pain reliever) and an antipyretic (fever reducer) that works by blocking the production of a specific chemical in the brain that causes pain and fever
    • Help reset the body's internal clock to help relieve symptoms of insomnia
    • Helps improve activity level and mood

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  • Dosage

    Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

    • For Adults, the usual dose of Tramadol HCl 37.5mg is one tablet every four hours as needed for pain, with a maximum of eight tablets per day.
    • The recommended dose of Paracetamol 325mg is one to two tablets every four hours, with a maximum of eight tablets per day.
    • The combination of Tramadol and Paracetamol in this dosage is proven to be safe and provides effective relief from pain.

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  • In case of Overdose

    In case of a Tramadol overdose, seek immediate medical help. If the person is not breathing, perform CPR, and if they are breathing, place them in the recovery position. Consider placing a Naloxone tablet under their tongue to mitigate overdose effects. Once emergency services arrive, provide information on drugs taken, and follow their instructions. Tramadol overdoses can be fatal, so prompt intervention is crucial for the best chance of recovery.

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  • Missed Dose

    It is important to take Tramadol HCl 37.5mg, Paracetamol 325mg as soon as possible if you miss a dose. If it is almost time for your next dose, skip the missed dose and continue on your regular schedule. However, you should not double up on doses to make up for the missed one. To ensure the safe and effective use of this medication, it is important to follow the dosage instructions and precautions provided by your doctor or pharmacist. If you have any questions or concerns about missing a dose, please consult your doctor or pharmacist for professional advice.

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  • How To Use

    Before taking Tramadol HCl 37.5mg, Paracetamol 325mg, it's essential to carefully read the warning label and understand the risks associated with its use, especially if you are pregnant. The medication is available in capsule form, and you should take it whole with a full glass of water, with or without food. Do not crush or chew the tablet, as it can lead to unintended side effects. If you have difficulty swallowing the capsule, you may open it and sprinkle the pellets onto a tablespoon of applesauce, then swallow immediately without chewing. It's important not to exceed the recommended dose or take the medication more frequently than every six hours, as this can lead to overdose and death. If you miss a dose, take it as soon as possible, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. While taking this medication, you should avoid driving or operating heavy machinery until you know how it affects you, as it may cause dizziness, dizziness, or drowsiness. You should also avoid alcohol and other medications that cause drowsiness unless prescribed by your doctor. In terms of storage, keep the medication at room temperature, away from heat, cold, or moisture. If you have any further questions or concerns about using this medication, consult with your doctor or pharmacist.

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  • When Not to Use

    Discerning instances where this medication may not be appropriate:

    • You are allergic to tramadol or paracetamol (acetaminophen) or any of the other ingredients in this medicine.
    • You have acute alcoholism.
    • You have kidney or liver disease including acute and chronic liver disease, cirrhosis, or acute worsening of chronic liver disease.
    • You have asthma or other respiratory conditions affecting the breathing.
    • You have uncontrolled seizures or head trauma, or after recent brain operations.
    • You have pressure in the brain (increased intracranial pressure) - for example, due to meningitis or skull fracture.
    • You have uncorrected adrenal insufficiency, pronounced constipation.
    • You have myasthenia gravis.
    • You are pregnant or planning to become pregnant or breastfeeding.
    • You are taking any other medicines which affect the central nervous system, cause drowsiness, or stimulate physical activity, including herbal medicines and stimulants (this includes caffeine).

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  • Side Effects

    Unraveling the side effects lurking behind this medications are as follows:

    • Constipation
    • Diarrhea
    • Dry mouth
    • Fatigue
    • Nausea
    • Vomiting
    • Irritability
    • Confusion
    • Dizziness
    • Sweating
    • Urge to urinate
    • Loss of appetite

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  • Precautions & Warnings

    Here are some important precautions and warnings for patients to consider:

    • Patients with hypovolemia or cardiovascular disease (including acute myocardial infarction) should be monitored closely.
    • Individuals with a history of seizures or risk factors for seizures (e.g. CNS infection, metabolic disorders, malignancy, alcohol/drug withdrawal), delirium tremens, head injury, intracranial lesions, or elevated intracranial pressure should exercise caution.
    • Those with toxic psychosis, emotional disturbances including depression, a history of drug abuse or acute alcoholism, or acute abdominal conditions require special care.
    • Patients with adrenal insufficiency (e.g. Addison’s disease), biliary tract dysfunction, or acute pancreatitis should consult their healthcare provider.
    • Caution is advised for individuals with prostatic hyperplasia, urinary stricture, significant COPD or cor pulmonale, substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression.
    • Those with G6PD deficiency or thyroid dysfunction should take special precautions.
    • The medication is not recommended for patients with severe respiratory insufficiency.
    • Avoid use in patients with circulatory shock, impaired consciousness or coma, moderate to severe sleep-disordered breathing, and suicidal patients.
    • Cachectic, debilitated, or morbidly obese patients should be carefully evaluated.
    • Avoid abrupt withdrawal of the medication to prevent adverse effects.
    • Special care is needed for patients with renal and mild to moderate hepatic impairment, elderly individuals, and during pregnancy and lactation.

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  • Drug Interactions

    Drug interactions with paracetamol and tramadol include:

    • Central nervous system depressants (e.g., alcohol, benzodiazepines) (may enhance CNS depression)
    • Antidepressants (e.g., SSRIs, SNRIs) (may increase the risk of serotonin syndrome)
    • Anticoagulants (e.g., warfarin) (paracetamol may enhance the effect of anticoagulants)
    • Other opioids (e.g., codeine) (may increase the risk of respiratory depression and sedation)
    • Hepatotoxic drugs (e.g., isoniazid) (paracetamol may increase the risk of liver damage)
    • Tramadol may interact with drugs that affect cytochrome P450 enzymes (e.g., CYP2D6 inhibitors)

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  • Storage/Disposal

    Store the paracetamol and tramadol combination at room temperature, away from moisture, heat, and direct light. Keep it in its original container, tightly sealed, and out of reach of children and pets. Avoid storing it in the bathroom. For disposal, do not flush it down the toilet or pour it into drains unless instructed. Follow local disposal guidelines or use a drug take-back program to safely discard unused or expired medication, preventing misuse or accidental exposure.

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