DITHRODERM 0.25% CREAM

Dithranol, the active ingredient in Dithranol Cream, exerts its therapeutic effects primarily through its antiproliferative and anti-inflammatory properties. The exact mechanism of action is not fully understood, but it is believed to involve multiple cellular processes. Dithranol interferes with the proliferation of epidermal cells by inhibiting DNA synthesis and disrupting cell division, leading to a reduction in the excessive skin cell growth associated with certain skin conditions. It also possesses anti-inflammatory effects, likely by inhibiting the production of pro-inflammatory mediators and reducing the activity of inflammatory cells. This dual action helps alleviate symptoms and improve the overall condition of the skin. Additionally, Dithranol may influence various signaling pathways and cellular processes, further contributing to its therapeutic benefits in the treatment of specific skin disorders.

Anthralin-based topical treatment.

Cream

The following are the uses of Dithranol Cream:

• Used for the treatment of psoriasis, a skin condition characterized by red, scaly patches.
• Used to reduce inflammation and slow down the rapid growth of skin cells in affected areas.
• Used to provide relief from itching and discomfort associated with psoriasis.
• Used in combination with other therapies, such as phototherapy, for more severe cases.
• Used as a short-term treatment option, as prolonged use may lead to skin thinning.
• Used for targeted application on specific areas affected by psoriasis plaques.
• Used to help manage symptoms and improve the overall appearance of the skin.

In the case of an overdose of Dithranol Cream, it is important to recognize the signs and act swiftly. Overapplication or ingestion may result in symptoms such as skin irritation, redness, or gastrointestinal discomfort. If these symptoms occur, remove the cream and thoroughly wash the affected area with mild soap and water. Seek medical advice for further treatment and monitoring to ensure a swift recovery.

In the case of a missed dose of Dithranol Cream, it is generally recommended to apply the medication as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of skin irritation. If you frequently miss doses, it is advisable to set reminders or use a dosing schedule to help you stay on track with your treatment plan.

To apply Dithranol Cream, clean and dry the affected skin area, then gently rub a thin layer of the cream onto the skin, ensuring coverage of the entire affected area, and follow the recommended application frequency as advised by your healthcare professional.

Following are the conditions/situations when Dithranol Cream should not be used:

• Do not use on broken or infected skin, or on skin with open wounds.
• Avoid contact with eyes, mouth, and other mucous membranes.
• Contraindicated in individuals with a known allergy to Dithranol or any of the excipients in the cream.
• Not suitable for children without medical supervision.
• Do not use on skin conditions that have not been diagnosed by a doctor.
• Avoid using on large areas of the body without medical advice.
• Do not use if the cream changes color or develops an unusual odor.
• Discontinue use and seek medical attention if you experience severe burning, irritation, or skin reactions.

The side effects of Dithranol Cream may include:

• Skin irritation at the application site
• Redness or inflammation of the skin
• Itching or burning sensation
• Dryness or peeling of the skin
• Temporary staining of the skin and nails
• Skin rash or hives
• Allergic reactions (such as difficulty breathing, swelling of the face/lips/tongue)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Dithranol Cream:

• Avoid contact with eyes, nose, mouth, and other mucous membranes. In case of accidental contact, rinse thoroughly with water.
• Do not apply to broken or inflamed skin, and do not use on open wounds.
• This cream is for external use only and should not be ingested.
• Wash your hands thoroughly after applying the cream to avoid accidental transfer to sensitive areas.
• Discontinue use if you experience severe irritation, burning, or any allergic reaction, and consult a healthcare professional.
• Keep out of reach of children and pets to prevent accidental ingestion.
• Do not use this medication for conditions other than those prescribed by your doctor.

Following are the drug interactions for Dithranol Cream:

• Topical corticosteroids, when used with Dithranol Cream, can cause skin atrophy and mask the early signs of skin irritation.
• Anticoagulants like warfarin may experience increased bleeding risk due to the potential irritating effects of Dithranol on the skin.
• Combining Dithranol with other topical treatments like salicylic acid or coal tar may increase skin irritation and sensitivity.
• Dithranol may enhance the photosensitivity caused by other medications, increasing the risk of sunburn.
• Certain antibiotics, such as tetracyclines, can make the skin more sensitive to sunlight, and using Dithranol Cream simultaneously may exacerbate this effect.
• The absorption of other topical medications may be altered due to the occlusive nature of Dithranol Cream.
• Skin irritation and inflammation may be intensified when Dithranol Cream is used with other irritant or sensitizing agents.

Following are the food interactions to consider with Dithranol Cream:

• Dithranol may cause staining, so it is advisable to avoid direct contact with food to prevent accidental ingestion and staining of food items.
• Wash your hands thoroughly after applying the cream to prevent transferring the medication to food or your mouth.
• Avoid consuming dark-colored beverages like grape juice or red wine, as they may temporarily stain the treated skin.
• Do not apply the cream to areas where food contact is likely, such as hands or near the mouth, unless directed by your doctor.
• If you are using Dithranol on your scalp, ensure that you wear a shower cap or head covering when preparing or eating meals to avoid contamination.
• In case of oral Dithranol treatment, follow a diet low in fats and oils to minimize gastrointestinal side effects.
• Consult your doctor if you have concerns about potential interactions with specific foods or if you experience any unusual symptoms after eating.

Dithranol Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or moisture. Keep the cream tightly sealed in its original container to maintain its integrity and prevent contamination. Avoid storage in hot or humid environments, such as bathrooms or kitchens, as temperature and humidity fluctuations can impact the cream's effectiveness. Always check the expiration date before use, and properly dispose of any expired or unused cream. Do not dispose of it in sinks, toilets, or drains; instead, consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Dithranol Cream:

• Apply a thin layer to the affected skin area as directed by your healthcare professional.
• Wash your hands thoroughly before and after application to prevent spreading the medication.
• Use the cream as a short-term treatment; prolonged use may cause skin irritation.
• Avoid applying to broken or infected skin, and do not cover the treated area with a bandage.
• Do not apply to sensitive areas like the face, groin, or underarms unless instructed by your doctor.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Consult your doctor if you experience severe skin reactions or if symptoms persist or worsen.