Dobalta (60mg) 14 Capsules

Dobalta (60mg) 14 Capsules

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  • Manufacturer GENETICS PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Duloxetine 60mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Laboratory Screening
  • Description

    Duloxetine 60mg capsules primarily act as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Its mechanism of action involves increasing the levels of serotonin and norepinephrine in the brain. Duloxetine blocks the reabsorption of these neurotransmitters by inhibiting their transporters, leading to enhanced neurotransmission. Specifically, duloxetine binds to the serotonin transporter (SERT) and the norepinephrine transporter (NET), preventing the reuptake of serotonin and norepinephrine into the presynaptic neuron. This results in increased concentrations of these neurotransmitters in the synaptic cleft, which can improve mood, emotional regulation, and pain signaling, making it effective in the treatment of depression, anxiety disorders, and certain types of chronic pain conditions.

  • Ingredients

    Duloxetine 60mg

  • Drug Class

    Serotonin-norepinephrine reuptake inhibitor (SNRI).

  • Dosage Form

    Capsule

  • Uses

    The following are the uses of Duloxetine 60mg Capsule:

    • Used for managing depression, helping to alleviate symptoms and improve mood.
    • Used for treating generalized anxiety disorder, reducing excessive worry and promoting relaxation.
    • Used for alleviating chronic pain associated with conditions like fibromyalgia, offering pain relief and improved daily functioning.
    • Used for managing nerve pain, particularly diabetic peripheral neuropathy, providing relief from burning or tingling sensations.
    • Used for treating chronic musculoskeletal pain, such as back pain or osteoarthritis pain, aiding in pain management and mobility.
    • Used for certain types of urinary incontinence, helping to control bladder function and reduce leakage.
    • Used for supporting individuals with major depressive disorder, assisting in emotional regulation and overall well-being.
  • Dosage

    Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

    • Depression - 60 mg per day in divided doses (morning and evening)
    • Diabetic Neuropathic Pain - 60 mg once daily
    • Generalized Anxiety Disorder - 60 mg once daily
    • Osteoarthritis - 20-60 mg per day in a single dose
    • Chronic Musculoskeletal Pain - 20-60 mg per day in a single dose
    • Fibromyalgia - 20-60 mg per day in a single dose
    • Irritable Bowel Syndrome - Capsules - 20 mg once daily; Tablets - one tab acting twice daily
    • Neurological Pain - 60 mg once daily
    • Stress Incontinence - 60 mg once daily
    • Epilepsy - Consult a medical professional for the proper dosage
  • In case of Overdose

    In the case of an overdose of Duloxetine 60mg Capsules, it is important to act promptly. Symptoms may include drowsiness, vomiting, seizures, rapid heartbeat, and even loss of consciousness. If you suspect an overdose, contact emergency services or seek medical help immediately. Quick action can be vital, as prompt treatment may prevent serious health complications and ensure a better chance of recovery. Always keep medications out of reach of children to prevent accidental ingestion.

  • Missed Dose

    In the case of a missed dose of Duloxetine 60mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare professional for advice on how to safely resume your medication. It is generally recommended to take the missed dose within 12 hours of the intended time to maintain the drug's effectiveness.

  • How To Use

    To take Duloxetine 60mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, as directed by your healthcare provider, without crushing, chewing, or opening the capsule.

  • When Not to Use

    Following are the conditions/situations when Duloxetine 60mg Capsule should not be taken:

    • Do not take if you have a known allergy to Duloxetine or similar medications like SNRIs or SSRIs.
    • Avoid if you have narrow-angle glaucoma that is not controlled.
    • Do not use if you have recently taken a Monoamine Oxidase Inhibitor (MAOI) or are planning to take one.
    • Contraindicated in individuals with uncontrolled high blood pressure.
    • Should not be taken by patients with liver or kidney disease or severe kidney impairment.
    • Not recommended for patients with bleeding disorders or those on blood-thinning medications.
    • Do not use if you have a personal or family history of retinal bleeding or other eye problems.
    • Avoid if you have a history of seizures or conditions that increase the risk of seizures.
  • Side Effects

    The side effects of Duloxetine 60mg Capsule may include:

    • Nausea and vomiting
    • Dry mouth
    • Fatigue and drowsiness
    • Constipation or diarrhea
    • Dizziness or lightheadedness
    • Headaches
    • Increased sweating
    • Changes in appetite and weight
  • Precautions & Warnings

    Following are the precautions and warnings for Duloxetine 60mg Capsule:

    • Not recommended for individuals with a known hypersensitivity or allergy to Duloxetine or any other ingredients in the capsule.
    • Patients with a history of liver or kidney disease should exercise caution, as these conditions may affect the metabolism and elimination of the drug.
    • Avoid alcohol consumption while taking Duloxetine as it may increase the risk of side effects and impair mental alertness.
    • Patients with a history of seizures or conditions that increase seizure risk should be closely monitored, as Duloxetine may lower the seizure threshold.
    • Not suitable for individuals with uncontrolled narrow-angle glaucoma, as it may worsen the condition.
    • May cause an increase in blood pressure, so regular monitoring is necessary, especially in patients with hypertension.
    • Should be used with caution in patients with diabetes, as it may affect blood sugar levels.
    • Discontinuation of Duloxetine should be gradual to minimize the risk of withdrawal symptoms.
  • Drug Interactions

    Following are the drug interactions for Duloxetine 60mg Capsule:

    • Concomitant use with other antidepressants like SSRIs, MAOIs, or tricyclic antidepressants can lead to increased side effects and potential serotonin syndrome.
    • Duloxetine may enhance the effects of anticoagulants, such as warfarin, requiring close monitoring of coagulation.
    • Taking Duloxetine with other CNS-active drugs (e.g., benzodiazepines, opioids) can increase sedation and respiratory depression.
    • Therapeutic effects of Duloxetine may be reduced when used with rifampicin, a strong CYP1A2 inducer.
    • Grapefruit juice should be avoided as it can increase Duloxetine concentrations, leading to more side effects.
    • The use of Duloxetine with antihypertensive medications may result in increased hypotensive effects.
    • Duloxetine can increase plasma concentrations of certain anticonvulsants, such as phenytoin, requiring dose adjustments.
  • Food Interactions

    Following are the food interactions to be aware of with Duloxetine 60mg Capsule:

    • Avoid consuming alcohol while taking this medication, as it can increase the risk of side effects such as drowsiness and dizziness.
    • Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Duloxetine, leading to increased drug levels in the body.
    • Avoid eating high-fat meals as they may decrease the absorption of Duloxetine, potentially reducing its effectiveness.
    • Caffeine intake should be limited as it can increase anxiety and restlessness, especially when combined with Duloxetine.
    • Avoid tyramine-rich foods like aged cheeses, cured meats, and fermented foods, as they may interact with Duloxetine and increase blood pressure.
    • Consuming foods high in salt and sugar should be minimized, as Duloxetine can affect blood pressure and blood sugar levels.
    • There is no specific food restriction, but maintaining a balanced diet is advisable for overall well-being during the medication period.
    • Always follow the advice of your healthcare professional regarding dietary considerations while taking Duloxetine.
  • Storage/Disposal

    Duloxetine 60mg capsules should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the medication in its original container, tightly sealed, to maintain its integrity and protect it from moisture. Avoid exposure to direct sunlight or excessive heat, as this can degrade the medication. It is crucial to check the expiration date regularly and not to use the capsules beyond their expiry. When disposing of unused or expired capsules, do not throw them in the trash or flush them down the toilet. Instead, consult your pharmacist or local waste management authority for safe disposal options to minimize environmental impact. Keep the medication out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Duloxetine 60mg Capsule:

    • Start with a lower dose and gradually increase as directed by your doctor to minimize side effects.
    • Swallow the capsule whole with a full glass of water; do not crush, chew, or open it.
    • Take the capsule at the same time each day to maintain consistent blood levels.
    • It may take a few weeks to notice the full benefits, so continue taking it as prescribed.
    • Avoid alcohol consumption while taking this medication to prevent adverse interactions.
    • Store the capsules in a cool, dry place, away from direct sunlight and moisture.
    • Do not share your medication with others, even if they have similar symptoms.
  • Laboratory Screening

    When taking Duloxetine Hydrochloride 60mg, it is vital to follow the advice of your healthcare provider and undergo the necessary laboratory tests to ensure your safety and well-being. These tests can identify changes and abnormalities that may occur during treatment with Duloxetine Hydrochloride, which is why it is important to remain aware of your symptoms and alert your doctor if you experience any concerning symptoms. Here are a few of the essential lab tests to consider:

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