Dolofen-F (400mg) 10 Capsules

Ibuprofen, a 400mg capsule, exerts its mechanism of action by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are mediators of inflammation and pain. By blocking the action of COX enzymes, ibuprofen reduces the production of prostaglandins, thereby alleviating pain, inflammation, and fever. It achieves this by binding to the active site of the COX enzymes, preventing the conversion of arachidonic acid into prostaglandin H2, a precursor to various prostaglandins. This inhibition leads to decreased levels of prostaglandins at the site of inflammation, resulting in reduced pain, swelling, and temperature regulation. Ibuprofen's selective inhibition of COX enzymes contributes to its effectiveness in managing mild to moderate pain and inflammatory conditions.

Ibuprofen 400mg

Non-steroidal anti-inflammatory drug (NSAID)

Capsule

The following are the uses of Ibuprofen 400mg Capsule:

• Used for relieving mild to moderate pain, such as headaches, toothaches, and backaches.
• Used for reducing inflammation and managing symptoms of conditions like arthritis.
• Used for lowering fever and treating symptoms of the common cold or flu.
• Used for alleviating menstrual cramps and discomfort.
• Used for reducing discomfort after minor surgeries or medical procedures.
• Used for treating pain and inflammation associated with minor injuries.
• Used for providing temporary relief from minor aches and pains.

In the case of an overdose of Ibuprofen 400mg Capsules, it is important to recognize the symptoms, which may include nausea, vomiting, abdominal pain, and in severe cases, kidney damage. Prompt action should be taken, such as contacting a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the individual's condition, which may include inducing vomiting or administering activated charcoal to minimize the absorption of the excess medication.

In the case of a missed dose of Ibuprofen 400mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication without compromising its effectiveness. It is generally advised to take the medication with food to minimize stomach irritation.

To take Ibuprofen 400mg Capsules, swallow the capsule whole with a full glass of water, preferably with or after food, following the dosage instructions provided by your healthcare professional, typically one capsule every 4 to 6 hours as needed, but not exceeding 3 capsules in 24 hours unless directed by a doctor.

Following are the conditions when Ibuprofen 400mg Capsule should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Ibuprofen, aspirin, or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
• Contraindicated in patients with active or recent gastrointestinal bleeding or perforation.
• Not suitable for individuals who have had a recent heart attack or coronary artery bypass surgery.
• Should be avoided in patients with severe heart failure or heart disease.
• Contraindicated in individuals with active peptic ulcer or a history of peptic ulcer disease.
• Not recommended for patients with severe kidney or liver impairment.
• Should not be used by pregnant women in their third trimester.
• Contraindicated in patients with bleeding disorders or those on blood-thinning medications.
• Avoid using Ibuprofen if you have uncontrolled hypertension (high blood pressure).
• Not suitable for individuals with a history of asthma or allergic reactions triggered by NSAIDs.

The side effects of Ibuprofen 400mg Capsule may include:

• Stomach pain or upset
• Nausea and vomiting
• Diarrhea
• Constipation
• Dizziness or vertigo
• Headache
• Drowsiness or fatigue
• Skin rash or itching

Following are the precautions and warnings:

• Ibuprofen 400mg Capsule should not be used in individuals with a known allergy or hypersensitivity to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs (NSAIDs).
• This medication may increase the risk of cardiovascular events like heart attack or stroke, especially with prolonged use. Patients with existing heart conditions should use it with caution.
• Prolonged use or high doses may cause gastrointestinal bleeding, ulcers, or perforation. Individuals with a history of stomach problems should exercise caution and consult a healthcare professional.
• Ibuprofen can affect kidney function, particularly in patients with pre-existing kidney disease, the elderly, or those taking diuretics. Regular monitoring of kidney function is advised.
• Caution is advised in individuals with a history of liver problems, as ibuprofen is metabolized by the liver. Liver function tests may be required for long-term use.
• Patients with asthma or other respiratory conditions may experience bronchospasm or worsening of symptoms. Discontinue use if breathing difficulties occur.
• Ibuprofen may increase blood pressure, and patients with hypertension should be monitored regularly. Adjustments in blood pressure medications may be necessary.
• It is important to stay hydrated while taking this medication, as dehydration can increase the risk of kidney problems.

Following are the drug interactions for Ibuprofen 400mg Capsule:

• Aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of stomach bleeding and ulcers when taken with ibuprofen.
• Ibuprofen can reduce the blood pressure-lowering effects of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs).
• The diuretic effect of loop diuretics like furosemide may be decreased by ibuprofen.
• Ibuprofen may increase blood levels of lithium, leading to potential toxicity.
• Anticoagulants like warfarin may have their blood-thinning effects enhanced, increasing bleeding risk.
• Ibuprofen can reduce the effectiveness of antihypertensive medications, such as beta-blockers and diuretics.
• Corticosteroids and ibuprofen together may increase the risk of gastrointestinal bleeding and ulcers.

Following are the food interactions for Ibuprofen 400mg Capsule:

• Alcohol consumption should be avoided or limited as it may increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Ibuprofen, potentially increasing its levels in the body and raising the risk of side effects.
• High-fat meals may delay the absorption of Ibuprofen, but this generally does not impact its overall effectiveness.
• Avoid caffeine-rich foods and beverages as they may increase the risk of nervousness, insomnia, and rapid heartbeat when combined with Ibuprofen.
• Ibuprofen can be taken with or without food, but taking it with food can reduce the risk of stomach upset and irritation.
• Avoid excessive salt intake, as Ibuprofen may cause sodium and water retention, leading to edema.
• Limit the intake of spicy foods as they can irritate the stomach, especially when taking Ibuprofen regularly.
• Certain herbal supplements like Ginkgo Biloba and garlic may increase the risk of bleeding when used with Ibuprofen.

Ibuprofen 400mg capsules should be stored in a cool, dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storing it in the bathroom or near heat sources. Regularly check the expiration date, and if the capsules are no longer needed or have expired, proper disposal is essential. Do not dispose of them by flushing or pouring down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Ibuprofen 400mg Capsule:

• Consult a doctor for personalized advice and dosage recommendations.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Take with or after food to minimize stomach irritation.
• Do not lie down immediately after taking the capsule, stay upright.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Inform your doctor if you have a history of gastrointestinal issues.
• Store in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even with similar symptoms.