Dolonap SR (750mg) 10 Tablets

Naproxen 750mg tablets primarily exert their therapeutic effect through their action as a nonsteroidal anti-inflammatory drug (NSAID). This medication is a propionic acid derivative that inhibits the enzyme cyclooxygenase (COX), which exists in two isoforms, COX-1 and COX-2. By blocking these enzymes, naproxen decreases the formation of prostaglandins, which are key mediators of inflammation, pain, and fever. Specifically, naproxen has a higher selectivity for COX-1 than COX-2, but it inhibits both isoforms, leading to reduced production of prostaglandin precursors and subsequent pain relief, decreased inflammation, and antipyretic effects. The inhibition of COX enzymes and subsequent reduction in prostaglandin synthesis underlie the primary mechanism of action of naproxen in managing various conditions associated with pain, inflammation, and fever.

NSAID (Nonsteroidal Anti-Inflammatory Drug)

Tablet

The following are the uses of Naproxen 750mg Tablet:

• Used for relieving acute pain, such as headaches, muscle aches, and menstrual cramps.
• Used for reducing inflammation caused by conditions like arthritis, tendonitis, and gout.
• Used to manage chronic pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis.
• Used for fever reduction, especially in cases where other medications may not be suitable.
• Used post-surgery to control pain and inflammation during recovery.
• Used for the short-term relief of minor aches and pains associated with the common cold or flu.

In the case of an overdose of Naproxen 750mg Tablets, the severity of symptoms can vary depending on the amount ingested. Common symptoms may include stomach pain, nausea, vomiting, drowsiness, and dizziness. In more severe cases, individuals may experience difficulty breathing, rapid heartbeat, and even seizures. It is important to seek medical assistance promptly, as treatment options may include inducing vomiting, administering activated charcoal, or providing supportive care in a healthcare setting.

In the case of a missed dose of Naproxen 750mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice on how to proceed, as they may recommend adjusting your dosage accordingly. It is crucial to adhere to the prescribed dosage regimen for optimal therapeutic benefits.

To take Naproxen 750mg Tablet, swallow the tablet whole with a full glass of water, preferably with food or after a meal, as directed by your healthcare professional, usually once or twice a day, and do not lie down for at least 10 minutes after taking the medication.

Naproxen 750mg Tablet should not be used in the following conditions or situations:

• Avoid using if you have a known allergy or hypersensitivity to Naproxen, other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), or any of its inactive ingredients.
• Do not take this medication if you have a history of gastrointestinal bleeding or perforation after taking NSAIDs.
• Contraindicated in individuals with severe heart failure or heart disease.
• Should not be used by patients with active stomach or intestinal ulcers or bleeding.
• Avoid using if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Not recommended for individuals with severe kidney or liver impairment.
• Do not take this medication if you have a history of allergic reactions or asthma triggered by aspirin or other NSAIDs.
• Contraindicated in patients with a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Naproxen 750mg Tablet may include:

• Stomach pain or upset
• Nausea and vomiting
• Diarrhea
• Heartburn or indigestion
• Dizziness or lightheadedness
• Headache
• Drowsiness or fatigue
• Skin rash or itching

Following are the precautions and warnings for Naproxen 750mg Tablet:

• Avoid if allergic to Naproxen or other similar medications; seek medical attention if an allergic reaction occurs.
• Patients with a history of gastrointestinal bleeding, ulcers, or other stomach disorders should use with caution and under medical supervision.
• Kidney function should be monitored regularly, especially in elderly patients or those with pre-existing kidney issues.
• Not recommended for use during pregnancy, especially in the third trimester, without medical advice.
• Consult a doctor before breastfeeding while using Naproxen.
• Avoid alcohol consumption as it may increase the risk of gastrointestinal bleeding.
• This medication may increase blood pressure; monitor blood pressure regularly.
• Naproxen may cause dizziness or drowsiness; do not drive or operate heavy machinery until you know how this medication affects you.

Following are the drug interactions for Naproxen 750mg Tablet:

• Aspirin or other NSAIDs (e.g., ibuprofen, celecoxib) may increase the risk of gastrointestinal bleeding and ulcers when taken with Naproxen.
• Lithium levels can be increased by Naproxen, leading to potential lithium toxicity.
• Naproxen may reduce the effectiveness of antihypertensive medications, including beta-blockers and ACE inhibitors.
• When combined with diuretics, Naproxen may decrease their diuretic and antihypertensive effects.
• Anticoagulants like warfarin may have their effects enhanced by Naproxen, increasing the risk of bleeding.
• Naproxen can increase serum levels of methotrexate, potentially increasing its toxicity.
• The risk of kidney damage may be elevated when Naproxen is used with other nephrotoxic drugs, such as cyclosporine or tacrolimus.

Following are the food interactions to consider with Naproxen 750mg Tablet:

• Avoid excessive alcohol consumption while taking Naproxen, as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Naproxen may decrease the effectiveness of diuretics and beta-blockers, so inform your doctor if you regularly consume foods rich in potassium and magnesium.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Naproxen, leading to increased blood levels and potential side effects.
• Limit your salt intake, as Naproxen may reduce the effectiveness of salt and fluid restrictions in managing edema.
• Avoid high-fat meals, as they can slow down the absorption of Naproxen, delaying its pain-relieving effects.
• Caffeine-rich foods and beverages may increase the risk of nervousness and insomnia when taken with Naproxen.
• Consume a balanced diet to maintain a healthy stomach lining, as Naproxen can increase the risk of gastrointestinal issues.
• Avoid herbal supplements like Ginkgo Biloba and St. John's Wort, as they may interact with Naproxen and affect its effectiveness.

Naproxen 750mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures by not storing them in the bathroom or near heat sources. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not dispose of Naproxen tablets by flushing or pouring them down the drain; instead, consult your pharmacist for safe disposal methods to protect the environment. Always keep medications secure and out of the reach of children to prevent accidental consumption.

Following are the quick tips for Naproxen 750mg Tablet:

• Consult your doctor or pharmacist before use, especially if you have allergies or medical conditions.
• Take the tablet with a full glass of water, preferably with food, to reduce stomach irritation.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Inform your doctor if you have a history of heart disease, high blood pressure, or stroke.
• Regularly monitor your blood pressure and kidney function while taking this medication.
• Do not take this medication for longer than prescribed, and inform your doctor if symptoms persist.
• Store the tablets at room temperature, away from moisture and direct sunlight.