Doricum (0.025/0.5%) 10ml Eye Drops

The combination of Neomycin and Fluocinolone in drop form has a synergistic mechanism of action. Neomycin, an aminoglycoside antibiotic, binds to the bacterial ribosome, disrupting protein synthesis and effectively killing bacteria on the ocular surface. It primarily targets gram-negative bacteria, including Pseudomonas aeruginosa, which is commonly associated with eye infections. Fluocinolone, a synthetic corticosteroid, exerts its effect by inhibiting the production of pro-inflammatory mediators and suppressing the immune response. It reduces inflammation, redness, and itching by blocking the release of cytokines and other inflammatory substances. Together, Neomycin and Fluocinolone provide both antimicrobial and anti-inflammatory actions, making them effective in treating various eye conditions where bacterial infection and inflammation coexist.

Corticosteroid/Antibiotic

Drop

The following are the uses of Neomycin, Fluocinolone Drop:

• Used for treating bacterial infections in the eye, particularly those causing inflammation and redness.
• Used for providing relief from itching and irritation associated with eye infections.
• Used for reducing inflammation and swelling of the eye caused by certain conditions.
• Used for preventing the spread of bacterial eye infections to other parts of the eye or surrounding areas.
• Used for managing post-operative eye infections and preventing complications.
• Used for treating eye conditions like conjunctivitis, blepharitis, and corneal ulcers.
• Used for promoting faster healing and preventing further damage to the eye tissues.

In the case of an overdose of Neomycin and Fluocinolone Drops, it is important to remain calm and take appropriate actions. Rinse your eyes with warm water and contact a healthcare professional immediately. They will provide guidance and necessary treatment to address any potential adverse effects. Promptly seek medical advice to ensure the best possible outcome and to receive personalized care. Avoid delaying medical consultation to prevent any potential complications.

In the case of a missed dose of Neomycin and Fluocinolone Acetate Ophthalmic Suspension, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for further guidance on how to adjust your medication regimen.

To use Neomycin and Fluocinolone eye drops, wash your hands thoroughly, tilt your head back, gently pull down your lower eyelid, and hold the dropper close to your eye, dispensing the prescribed number of drops into the eye while looking upwards, then close your eyes gently to allow the medication to spread evenly.

Following are the conditions/situations when Neomycin, Fluocinolone Drop should not be used:

• Avoid using this medication if you have a known allergy to Neomycin, Fluocinolone, or any other antibiotics/steroids.
• Do not use this medication if you have a viral, bacterial, or fungal infection in the eye that is not being treated.
• Not suitable for individuals with a history of eye injury or eye surgery.
• Should not be used if you have a corneal ulcer or herpes infection in the eye.
• Contraindicated for those with tuberculosis or fungal infections in the eye.
• Do not use this medication if you have a thinning of the cornea or any other eye disease.
• Avoid using this drop if you have a condition that causes perforation or puncture of the ear.

The side effects of Neomycin, Fluocinolone Drop may include:

• Stinging or burning sensation in the eyes
• Itching or redness of the eyelids
• Blurred vision
• Skin irritation or rash around the eyes
• Eye discomfort or dryness
• Increased sensitivity to light (photophobia)
• Allergic reactions (e.g., swelling, itching, difficulty breathing)
• Prolonged use may lead to increased eye pressure and cataract formation.

Following are the precautions and warnings for Neomycin, Fluocinolone Drop:

• Do not use this medication if you are allergic to any of its ingredients, including neomycin or fluocinolone.
• This medication is for external use only; avoid contact with eyes and mucous membranes.
• Prolonged use of corticosteroids like fluocinolone can lead to increased intraocular pressure; monitor eye pressure during treatment.
• Do not use the drops if the solution changes color or becomes cloudy; discard any unused portion.
• Do not wear contact lenses while using this medication; it may contain preservatives that can be absorbed by the lenses.
• Exercise caution in patients with a history of tuberculosis or herpes simplex keratitis; corticosteroids may exacerbate these conditions.
• Pediatric use should be under the supervision of a healthcare professional due to potential side effects.

Following are the drug interactions for Neomycin, Fluocinolone Drop:

• When used with other ototoxic medications like gentamicin or furosemide, the risk of hearing loss increases.
• Neomycin can reduce the absorption of oral medications like levothyroxine and digoxin, requiring careful monitoring.
• The risk of nephrotoxicity is higher when combined with other nephrotoxic drugs, such as vancomycin or cisplatin.
• Fluocinolone may increase the systemic absorption of other topical corticosteroids, leading to potential side effects.
• Antifungal medications like clotrimazole may enhance the effects of fluocinolone, requiring dosage adjustments.
• Topical antibiotics like mupirocin could potentially interact, although the clinical significance is not well established.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) applied topically may increase the risk of skin irritation when used with fluocinolone.

Following are the food interactions for Neomycin, Fluocinolone Drop:

• Avoid consuming alcohol as it may increase the risk of side effects and cause irritation when used with this medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the medication's metabolism, leading to increased drug levels in the body.
• Dairy products like milk, yogurt, and cheese can reduce the absorption of the medication, so it is best to separate their consumption from taking the drops.
• Avoid high-fat meals as they can potentially slow down the absorption of the medication, affecting its effectiveness.
• Foods rich in vitamin K, such as leafy green vegetables, should be consumed in moderation as they can counteract the effects of Fluocinolone.
• Salt and salty foods may cause irritation and discomfort when used with this medication.
• Avoid caffeine-rich foods and beverages as they may enhance the medication's side effects, including nervousness and restlessness.
• Always consult your healthcare provider for specific dietary recommendations while using this medication.

Neomycin, Fluocinolone Drop should be stored at room temperature, ideally between 68°F and 77°F (20°C and 25°C), in its original container with the cap tightly secured. Protect it from excessive heat, direct sunlight, and moisture by keeping it away from windowsills, stoves, or other heat sources. Ensure the medication is stored in a safe and secure place, out of the reach of children and pets. Do not use the drops if the solution has changed color or become cloudy. Dispose of any unused or expired medication responsibly; do not pour it down the drain or flush it down the toilet. Contact your pharmacist or healthcare provider for appropriate disposal methods to ensure the safe handling and disposal of Neomycin, Fluocinolone Drop.

Following are the quick tips for Neomycin, Fluocinolone Drop:

• Wash your hands before and after using the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Close your eyes gently and apply light pressure to the inner corner of the eye for a few minutes to prevent drainage.
• If using other eye medications, wait at least 5 minutes before applying the next medication to avoid washout.
• Do not wear contact lenses while using the drops unless advised by your doctor.
• Store the drops at room temperature, away from direct sunlight and moisture.