Dowsul (25mg) 20 Tablets

Levosulpiride is a substituted benzamide drug that is a levo enantiomer of sulpiride, it is an atypical antipsychotic (neuroleptic or tranquilizers) and a prokinetic agent that exerts its antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It reduces dopamine-mediated nausea and vomiting by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and in hypothalamus. This drug increases the release of acetylcholine and in return increases the movement of the stomach and intestines and prevents reflux. Levosulpiride is a partial agonist of serotonin 5-HT1A, this partial agonism increases the release of serotonin which results in enhancement of its antiemetic effect.

Levosulpiride

Tablet

Schizophrenia, Irritable bowel syndrome, GERD (Gastroesophageal Reflux Disease), Dyspepsia, Indigestion, Frequent Heartburn, Premature Ejaculation, Bipolar Disorder, Depression, Anxiety Disorder and Vertigo.

Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: For the treatment of functional digestive symptoms: 25mg 3 times a day. For the treatment of schizophrenia: 200-300mg a day, divided into 3 doses.

Excessive overdose of this medicine may cause restlessness, sleep disturbances, and tremors. Consult your doctor in case of overdose.

In case you missed any dose, take the next dose as soon as you remember but don't double your next dose to compensate for the missed one.

This medicine should be taken orally as advised by the doctor.

This drug must be avoided in elderly people, in children less than 14 years of age, renal or hepatic insufficiency, porphyrias, Parkinson's disease, severe history of epilepsy, manic states, alcohol intoxication, malignant mastopathies, GI bleeding, hyperprolactinemia, cardiac impairment, breast cancer, certain tumors like; pituitary prolactinoma, Hypokalemia, and phaeochromocytoma.

Headache Drowsiness Fatigue Irregular Menstrual Periods Constipation Weight gain Increased prolactin level in blood Increased salivation Excessive Sweating Gynecomastia (change in breast size) Abnormal Heart Rate Abdominal cramps

This medicine may impair the ability to operate machinery or drive a vehicle so care must be taken. Caution must be taken while prescribing this medicine to pregnant women; this medicine must be recommended to pregnant ladies only when its benefits are increasing then its risk factors. The drug is secreted in breast milk, so, its use should be restricted in breastfeeding women.

Store at 25°C. Protect from heat and moisture.