Doxagit (2mg) 20 Tablets

Doxazosin Mesylate 2mg Tablet primarily exerts its therapeutic effects through selective blockade of post-synaptic alpha-1 adrenergic receptors in various tissues. By specifically targeting these receptors, doxazosin mesylate inhibits the contractile effects of norepinephrine and other catecholamines on smooth muscle in the vascular system. This mechanism leads to vasodilation, particularly in peripheral resistance vessels, resulting in decreased peripheral vascular resistance and reduced blood pressure. The relaxation of smooth muscle in blood vessels is responsible for the antihypertensive effects of doxazosin mesylate. Additionally, its alpha-1 adrenergic blocking action contributes to improved blood flow, particularly in conditions where alpha-1 receptor activity is heightened, such as in benign prostatic hyperplasia, where it relaxes smooth muscle in the prostate and bladder neck, thereby relieving urinary outflow obstruction.

Doxazosin Mesylate 2mg

Alpha-1 adrenergic blocker.

Tablet

The following are the uses of Doxazosin Mesylate 2mg Tablet:

• Used for treating high blood pressure, helping to lower and control it.
• Used for managing benign prostatic hyperplasia (BPH), reducing related urinary symptoms.
• Used for promoting better urine flow and reducing frequent, urgent, or difficult urination.
• Used for relieving pelvic discomfort and pain associated with BPH.
• Used for improving quality of life in patients with BPH.
• Used for long-term management of BPH, requiring regular and consistent use.
• Used for preventing complications related to BPH, such as urinary tract infections.

In the case of an overdose of Doxazosin Mesylate 2mg Tablets, it is important to recognize the potential symptoms and seek assistance promptly. Overdose may lead to severe dizziness, fainting, or a sudden drop in blood pressure. If you suspect an overdose, contact a healthcare professional or poison control center immediately. They will provide guidance on the necessary steps to take, which may include medical monitoring and supportive care to manage symptoms.

In the case of a missed dose of Doxazosin Mesylate 2mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Doxazosin Mesylate 2mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, who will determine the appropriate dosage based on your medical condition and response to treatment.

Here are the conditions or situations when Doxazosin Mesylate 2mg Tablet should not be used:

• Should not be used in patients with a known allergy to Doxazosin Mesylate or similar medications.
• Contraindicated in patients with a history of orthostatic hypotension (sudden drop in blood pressure upon standing).
• Not suitable for individuals with severe liver or kidney disease.
• Should not be used in patients with a history of heart failure or unstable angina.
• Contraindicated during pregnancy or breastfeeding.
• Not recommended for children or adolescents.
• Should be avoided in patients with a history of eye surgery for glaucoma.
• Do not use if you have a condition called aortic stenosis, a narrowing of the main heart valve.
• Not suitable for patients with a rare genetic problem of galactose intolerance.

The side effects of Doxazosin Mesylate 2mg Tablet may include:

• Dizziness or lightheadedness, especially when standing up or sitting up suddenly
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Drowsiness
• Skin rash or itching
• Palpitations or irregular heartbeat
• Swelling of the hands, feet, or ankles

Following are the precautions and warnings for Doxazosin Mesylate 2mg Tablet:

• Patients with a known allergy to Doxazosin Mesylate or similar medications should not take this tablet.
• Blood pressure should be monitored regularly during treatment, especially in patients with hypertension.
• Caution is advised for patients with a history of kidney or liver disease, as dosage adjustments may be necessary.
• Doxazosin may cause dizziness and fainting, especially when standing up suddenly; patients should rise slowly and exercise caution.
• Patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Elderly patients may be more sensitive to the side effects; dosage adjustments might be required.
• This medication should be used with caution in patients with a history of heart disease or heart rhythm problems.

Following are the drug interactions for Doxazosin Mesylate 2mg Tablet:

• Drugs that can lower blood pressure, such as ACE inhibitors or beta-blockers, may have an additive effect when used with Doxazosin, leading to excessive hypotension.
• Concomitant use with phosphodiesterase-5 (PDE5) inhibitors (e.g., sildenafil, tadalafil) can cause significant drops in blood pressure.
• Doxazosin may interact with alpha-adrenergic antagonists, resulting in increased risk of orthostatic hypotension.
• Drugs that affect the metabolism of CYP3A4 enzyme, such as ketoconazole or erythromycin, can increase Doxazosin levels.
• The effectiveness of Doxazosin may be reduced when used with NSAIDs (e.g., ibuprofen), potentially impacting blood pressure control.
• Antihistamines and certain antidepressants may enhance the sedative effects of Doxazosin.
• Doxazosin may interact with diuretics, especially loop diuretics, potentially leading to dehydration and electrolyte imbalances.

Following are the food interactions to consider with Doxazosin Mesylate 2mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they may increase the levels of Doxazosin in the blood, potentially leading to increased side effects, particularly related to blood pressure regulation.
• Alcohol intake should be limited as it can cause excessive dizziness and lightheadedness when combined with Doxazosin, especially upon standing up from a sitting or lying position.
• High-sodium foods should be consumed in moderation as Doxazosin is used to treat hypertension, and excessive salt intake can counteract its blood pressure-lowering effects.
• A balanced diet with potassium-rich foods like bananas, oranges, and spinach is recommended to maintain electrolyte balance, especially if Doxazosin is used for hypertension.
• Limit caffeine intake, as caffeine can increase blood pressure, which may counteract the effects of Doxazosin.
• Maintain a healthy diet low in saturated fats and cholesterol, as Doxazosin may be used in conditions associated with cardiovascular health.
• Avoid large, heavy meals as Doxazosin may cause postural hypotension, and large meals can exacerbate this effect.

Doxazosin Mesylate 2mg Tablets should be stored in a secure and dry location, preferably in their original container, away from heat, direct sunlight, and moisture. The bathroom cabinet is not an ideal storage place due to the potential for heat and moisture. Ensure the medication is kept out of children's reach to prevent accidental ingestion. Always check the expiration date, and do not use the medication if it is past this date. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, consult your pharmacist or a local waste disposal company for safe disposal methods, as improper disposal can harm the environment. It is crucial to handle and dispose of medications responsibly to protect both your health and the environment.

Following are the quick tips for Doxazosin Mesylate 2mg Tablet:

• Consult your doctor before starting this medication for personalized advice.
• Take the tablet as directed, usually once daily, at the same time each day.
• Swallow the tablet whole with a full glass of water; do not crush or chew it.
• You can take it with or without food, but be consistent with your choice.
• Avoid grapefruit and grapefruit juice as they may interact with the medication.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.