Duac (1.28/6.67%) 15g Gel

Benzoyl Peroxide and Clindamycin Gel work synergistically to combat acne. Benzoyl Peroxide exhibits a keratolytic effect, causing the skin to peel and unclogging pores. It also demonstrates potent bactericidal activity by releasing oxygen radicals, which inhibit the growth of Propionibacterium acnes, a key contributor to acne development. Clindamycin, a lincosamide antibiotic, exerts its antibacterial action by binding to the 50S subunit of bacterial ribosomes, thereby inhibiting protein synthesis in susceptible bacteria like P. acnes and Staphylococcus epidermidis. This dual mechanism effectively reduces the presence of acne-causing bacteria and helps prevent the formation of new acne lesions.

Benzoyl Peroxide, Clindamycin

Antibacterial, Keratolytic.

Gel

The following are the uses of Benzoyl Peroxide, Clindamycin Gel:

• Used for treating acne by reducing bacterial growth and inflammation
• Used for unclogging pores and preventing new acne lesions
• Used for reducing skin redness and swelling associated with acne
• Used for improving overall skin appearance and texture
• Used for managing acne vulgaris, a common form of acne
• Used for enhancing the effectiveness of acne treatment when combined with other therapies
• Used for spot treatment of individual acne lesions for faster healing
• Used for maintaining clear skin and preventing acne recurrence

To be applied once daily as a thin layer on affected area or as prescribed by doctor

In the case of an overdose of Benzoyl Peroxide and Clindamycin Gel, the primary concern is the potential for increased skin irritation and dryness. Excessive use may lead to severe redness, peeling, or a burning sensation at the application site. If ingested, it could cause gastrointestinal discomfort. It is essential to seek medical advice if any adverse effects occur, and individuals should strictly adhere to the prescribed usage guidelines to prevent such incidents.

In the case of a missed dose of Benzoyl Peroxide, Clindamycin Gel, it is recommended to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed application. If you frequently miss doses, consider setting reminders or alarms to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To use Benzoyl Peroxide, Clindamycin Gel, gently cleanse the affected skin area, then apply a thin layer of the gel once or twice daily, as directed by your healthcare provider, ensuring you cover the entire affected area while avoiding sensitive areas like the eyes and mouth.

Here are the conditions and situations when Benzoyl Peroxide, Clindamycin Gel should not be used:

• Avoid using if you have a known allergy or sensitivity to benzoyl peroxide, clindamycin, or any of the gel's components.
• Do not use if you have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.
• Not suitable for individuals with damaged or broken skin, eczema, or severe skin irritation.
• Avoid using on skin that is sunburned, windburned, dry, chapped, or irritated.
• Do not use on skin that is showing signs of dermatitis or rosacea.
• Should not be applied to large areas of the body or to open wounds.
• Not recommended for individuals who have shown hypersensitivity to lincomediaine antibiotics.

The side effects of Benzoyl Peroxide, Clindamycin Gel may include:

• Skin dryness, peeling, or scaling
• Redness or irritation at the application site
• Burning or stinging sensation
• Itching
• Swelling or inflammation
• Allergic reactions (such as rash, hives, or difficulty breathing)
• Changes in skin color (temporary whitening or darkening)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Benzoyl Peroxide, Clindamycin Gel:

• Avoid contact with eyes, nose, mouth, and other mucous membranes; if contact occurs, rinse thoroughly with water.
• This medication may cause skin irritation; discontinue use if severe irritation or allergic reaction occurs.
• It may increase sensitivity to sunlight; limit sun exposure and use sunscreen during treatment.
• Do not cover treated areas with airtight dressings or bandages.
• Inform your doctor if you have any skin conditions or are using other topical medications.
• This medication should be used with caution in pregnant or breastfeeding women under medical supervision.
• Keep out of reach of children and pets.

Following are the drug interactions for Benzoyl Peroxide, Clindamycin Gel:

• Erythromycin, a macrolide antibiotic, may interact, increasing the risk of antibiotic resistance.
• Topical retinoids like tretinoin or adapalene can cause increased skin irritation when used together.
• The gel may reduce the effectiveness of topical acne treatments containing benzoyl peroxide.
• Caution with drugs containing sulfur, resorcinol, or salicylic acid due to potential skin reactions.
• May decrease the antibacterial activity of chloramphenicol, a broad-spectrum antibiotic.
• Concomitant use with oral clindamycin may increase the risk of antibiotic-associated colitis.
• The gel can potentially reduce the efficacy of other topical medications if not applied at separate times.

Following are the food interactions for Benzoyl Peroxide, Clindamycin Gel:

• Avoid excessive exposure to sunlight and artificial UV light (tanning beds). The medication may cause increased sensitivity, making sunburns more likely.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit certain enzymes, potentially affecting drug metabolism.
• Alcoholic beverages might not directly interact with the medication, but they can worsen skin dryness and irritation, so consider limiting consumption.
• Avoid oily and greasy foods; they can increase acne breakouts and reduce the medication's effectiveness.
• Stay well-hydrated and maintain a balanced diet rich in vitamins and minerals to support skin health.
• Certain dairy products and high-sugar foods might contribute to acne; consider moderation in consumption.
• No significant interactions with specific foods are reported, but maintaining a healthy diet is generally advised.

Benzoyl Peroxide, Clindamycin Gel should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to adhere to the expiration date indicated on the packaging, and any unused or expired gel should be disposed of responsibly. Do not dispose of it through the sink or toilet; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the gel out of children's reach to prevent accidental contact or ingestion.

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Following are the quick tips for Benzoyl Peroxide and Clindamycin Gel:

• Wash your face gently before applying the gel.
• Apply a thin layer to the affected area as directed by your doctor.
• Avoid contact with eyes, nose, and mouth during application.
• Do not apply to broken or irritated skin.
• Give it time to absorb; wait a few minutes before applying other skincare products.
• Use regularly to see improvement in acne symptoms.
• Store the gel at room temperature and keep it away from direct sunlight.

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