Duride (40/5mg) 20 Tablets

Furosemide, a potent loop diuretic, primarily acts by inhibiting the Na+/K+/2Cl• co-transporter in the ascending loop of Henle. This inhibition disrupts the reabsorption of sodium and chloride ions, leading to increased excretion of sodium, chloride, and water, resulting in diuresis. Amiloride, on the other hand, is a potassium-sparing diuretic that blocks the epithelial sodium channels (ENaC) located in the late distal convoluted tubule and collecting duct of the nephron. By inhibiting ENaC, amiloride reduces sodium reabsorption, enhancing water excretion while minimizing potassium loss, thereby preventing hypokalemia, which can be a side effect of furosemide. When used together, these two diuretics have a synergistic effect, as amiloride complements the diuretic action of furosemide while mitigating its potential potassium-depleting effects.

Furosemide, Amiloride

Loop diuretic, Potassium-sparing diuretic.

Tablet

The following are the uses of Furosemide, Amiloride Tablet:

• Used for treating fluid retention and high blood pressure.
• Used to reduce excess fluid in the body caused by conditions like heart failure, liver disease, or kidney issues.
• Used to relax blood vessels, improving blood flow and lowering blood pressure.
• Used for managing hypertension, helping to control blood pressure and prevent complications.
• Used to promote fluid loss through urine, reducing swelling and improving breathing in conditions like pulmonary edema.
• Used to support heart function by reducing fluid buildup, especially in patients with congestive heart failure.
• Used to regulate the body's water and salt balance, ensuring proper hydration and electrolyte levels.
• Used for carefully monitoring and adjusting dosage to achieve the desired therapeutic effect while minimizing side effects.

In the case of an overdose of Furosemide and Amiloride tablets, individuals may experience symptoms such as excessive urination, dehydration, dizziness, and electrolyte imbalances. This can lead to a rapid decrease in blood pressure, causing lightheadedness and potential kidney damage. Prompt medical intervention is necessary, including monitoring vital signs, replenishing fluids, and possibly administering intravenous medications to stabilize the patient's condition.

In the case of a missed dose of Furosemide, Amiloride Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It's important not to double the dose to make up for a missed one. If you miss several doses, contact your healthcare professional for advice, as they may provide specific instructions based on your medical condition and treatment plan.

To take the Furosemide, Amiloride Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, ensuring that you follow the prescribed dosage and schedule provided by your doctor.

Here are the conditions and situations when Furosemide, Amiloride Tablet should not be used:

• Should not be used in patients with a known allergy to Furosemide or Amiloride or any other sulfonamide-derived medications.
• Contraindicated in individuals with severe kidney disease or those who are unable to urinate.
• Not recommended for patients with low potassium levels (hypokalemia) or those with high potassium levels (hyperkalemia) before treatment.
• Should be avoided in patients with severe liver disease as it may worsen their condition.
• Contraindicated during pregnancy, especially in the first and third trimesters, due to potential harm to the fetus.
• Not suitable for breastfeeding mothers as it can pass into breast milk and may harm the nursing infant.
• Should not be used in patients with Addison's disease (adrenal gland disorder) due to the risk of worsening the condition.
• Avoid in patients with diabetes, as it may alter blood sugar levels and require adjustments in diabetes medications.
• Not recommended for individuals with gout, as it can increase uric acid levels and potentially trigger gout attacks.

The side effects of Furosemide, Amiloride Tablet may include:

• Increased urination
• Low blood pressure (hypotension)
• Electrolyte imbalances, such as low potassium or sodium levels
• Dizziness or lightheadedness
• Dehydration
• Fatigue or weakness
• Muscle cramps
• Hearing disturbances, such as ringing in the ears (tinnitus)

Following are the precautions and warnings:

• Furosemide, Amiloride tablets should be used with caution in patients with kidney disease as it can further impair kidney function. Dosage adjustments may be necessary under medical supervision.
• Patients with liver disease should exercise caution and consult a doctor before using this medication, as it is metabolized by the liver and may require dosage modifications.
• This medication can cause significant potassium loss, especially when used alone with furosemide. Regular monitoring of potassium levels is essential, and potassium supplements may be prescribed to prevent or manage hypokalemia.
• Elderly patients may be more susceptible to the side effects of this medication, particularly dizziness and electrolyte imbalances. Close monitoring and dosage adjustments may be required.
• Diabetic patients should be aware that amiloride can raise blood sugar levels, and furosemide may cause an initial blood sugar increase followed by a decrease. Regular blood sugar monitoring is crucial during treatment.
• Avoid potassium-rich foods and potassium-containing salt substitutes while taking this medication to prevent excessive potassium levels in the body.
• Patients should be cautious and avoid activities that require alertness, such as driving or operating heavy machinery, as dizziness and lightheadedness are common side effects.
• Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions.

Following are the drug interactions for Furosemide, Amiloride Tablet:

• Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the diuretic and antihypertensive effects of furosemide.
• Furosemide may increase the risk of nephrotoxicity when used with aminoglycoside antibiotics, potentially causing hearing loss and kidney damage.
• Amiloride can increase the risk of hyperkalemia when combined with angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), or potassium-sparing diuretics.
• The use of lithium with furosemide may increase lithium levels, requiring close monitoring to avoid lithium toxicity.
• Sucralfate can reduce the absorption of furosemide, potentially decreasing its effectiveness.
• High-dose aspirin may compete with furosemide for renal tubular secretion, reducing its diuretic effect.
• Corticosteroids and ethacrynic acid may increase the risk of ototoxicity when used with furosemide.
• Non-potassium-sparing diuretics can increase the risk of hypokalemia, which amiloride may not fully counteract.

Following are the food interactions for Furosemide, Amiloride Tablet:

• Avoid consuming large amounts of salt substitutes or potassium-rich foods like bananas, oranges, tomatoes, and spinach as they can increase potassium levels in the body, which may be harmful when taking this medication.
• Alcohol consumption should be minimized or avoided as it can increase the risk of dehydration and electrolyte imbalances, especially when combined with the diuretic effect of Furosemide.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Amiloride, potentially leading to increased drug levels and an elevated risk of side effects.
• Avoid potassium supplements unless specifically advised by your doctor, as this medication can already affect potassium levels.
• Maintain a consistent intake of fluids and a balanced diet to ensure proper hydration and electrolyte balance.
• Avoid licorice or licorice-containing products as they may interact with Amiloride and affect blood pressure and potassium levels.
• Be cautious with a high-sodium diet, as it may reduce the effectiveness of Furosemide and potentially lead to fluid retention.
• Consult a healthcare professional for personalized advice on dietary restrictions and interactions, especially if you have specific dietary preferences or medical conditions.

Furosemide, Amiloride Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture. It is crucial to store them at room temperature, away from direct sunlight, heat sources, or extreme cold, as temperature fluctuations can impact their effectiveness. Remember to check the expiration date regularly and discard any expired medication responsibly. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste management guidelines for safe disposal options to minimize environmental impact. Always keep medications out of children's reach to ensure their safety.

Following are the quick tips for Furosemide, Amiloride Tablet:

• Always take the medication as directed by your doctor, typically once or twice daily.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Maintain a consistent schedule to ensure the drug's effectiveness.
• Do not crush or chew the tablet to prevent a bitter taste.
• Inform your doctor if you have liver or kidney problems, diabetes, or electrolyte imbalances.
• Regular blood tests may be required to monitor your body's response to the medication.
• Store the tablets at room temperature, away from moisture and light.