DUXIL TAB

Almitrine, the active ingredient in Raubasine tablets, acts primarily on the central nervous system to enhance respiratory drive and improve oxygenation. Its mechanism of action involves stimulating peripheral chemoreceptors in the carotid bodies, which are sensitive to changes in blood oxygen and carbon dioxide levels. By activating these chemoreceptors, almitrine increases the sensitivity of the respiratory control center in the brainstem to hypoxia (low oxygen levels) and hypercapnia (high carbon dioxide levels). This heightened sensitivity leads to increased respiratory rate and depth, promoting better oxygenation of the blood and tissues. Almitrine's selective action on the peripheral chemoreceptors helps to restore a more efficient breathing pattern, particularly in conditions where respiratory function is compromised, such as chronic obstructive pulmonary disease (COPD) and respiratory depression.

Almitrine, Raubasine

Respiratory stimulant.

Oral

The following are the uses of Almitrine, Raubasine Tablet:

• Used for treating chronic obstructive pulmonary disease (COPD)
• Used to reduce shortness of breath and improve breathing in COPD patients
• Used for its ability to enhance oxygen use in the body
• Used for treating hypoxemia (low oxygen levels in blood)
• Used to stimulate breathing and improve respiratory function
• Used for managing respiratory distress associated with heart failure
• Used to reduce the workload on the heart by improving oxygen utilization
• Used for its potential to improve exercise tolerance in respiratory disorders

In the case of an overdose of Almitrine and Raubasine tablets, individuals may experience symptoms such as nausea, vomiting, dizziness, and confusion. Prompt medical attention is required as these symptoms can indicate a severe reaction. The affected person should be monitored for vital signs, and healthcare professionals should be informed about the type and quantity of the overdose. Treatment may involve supportive care and managing any adverse effects to ensure the patient's well-being.

In the case of a missed dose of Almitrine, Raubasine Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to resume your medication safely. It is best to establish a routine to ensure you take your medication at the same time each day to minimize the chances of missing a dose.

To take Almitrine, Raubasine Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor or as directed on the medication label.

Following are the conditions/situations when Almitrine, Raubasine Tablet should not be used:

• Should not be used in patients with known hypersensitivity or allergy to Almitrine or Raubasine.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Not recommended for individuals with severe kidney disease or kidney failure.
• Should not be used in patients with severe respiratory failure or acute respiratory distress syndrome (ARDS).
• Contraindicated in patients with a history of severe cardiovascular disease, including uncontrolled hypertension, recent myocardial infarction, or severe arrhythmias.
• Not suitable for individuals with a history of seizures or epilepsy.
• Should be avoided in patients with a history of severe psychiatric disorders, including psychosis or severe depression.
• Not recommended for individuals with a history of gastrointestinal obstruction or severe gastrointestinal disorders.
• Should not be used during pregnancy or breastfeeding.

The side effects of Almitrine, Raubasine Tablet may include:

• Nausea and vomiting.
• Abdominal pain.
• Headache.
• Dizziness or lightheadedness.
• Dry mouth.
• Sleep disturbances (insomnia or excessive sleepiness).
• Skin rashes or itching.
• Increased heart rate or palpitations.

Following are the precautions and warnings for Almitrine, Raubasine Tablet:

• This medication should be used with caution in patients with severe respiratory or cardiac disorders, as it may exacerbate these conditions.
• Not recommended for individuals with a history of hypersensitivity or allergic reactions to the active ingredients or related compounds.
• Elderly patients may be more susceptible to the drug's side effects, particularly those related to the central nervous system.
• Patients with a history of liver disease should be closely monitored as the drug is primarily metabolized in the liver.
• Almitrine can cause drowsiness and dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• The tablet may interact with other medications, especially those that affect the central nervous system; inform your doctor about all medications you are taking.
• Consult a healthcare professional if you have a history of psychiatric disorders, as this medication may impact mental health.

Following are the drug interactions for Almitrine, Raubasine Tablet:

• Concomitant use with other respiratory stimulants, such as doxapram, may lead to excessive respiratory drive and potential respiratory alkalosis.
• Alcohol and central nervous system (CNS) depressants can potentiate the sedative effects of Raubasine, leading to increased drowsiness and impaired coordination.
• Anticoagulants like warfarin may have their effects enhanced, requiring close monitoring of coagulation parameters.
• Almitrine can interact with certain antibiotics, such as erythromycin, potentially increasing the risk of cardiac arrhythmias.
• The effects of beta-blockers may be reduced when used with Almitrine, requiring careful monitoring of blood pressure and heart rate.
• Anticonvulsants and antipsychotics may have their blood levels affected, potentially requiring dose adjustments.
• Drugs that affect liver enzymes, such as rifampicin, can alter the metabolism of Almitrine and Raubasine.

Following are the food interactions for Almitrine, Raubasine Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as it may lead to increased levels of the drug in the blood, potentially causing adverse effects.
• Alcohol intake should be limited or avoided as it can enhance the sedative properties of the medication, increasing the risk of dizziness and drowsiness.
• Caffeine-rich beverages like coffee and energy drinks might interfere with the medication's effectiveness, as they can stimulate the central nervous system.
• Consuming high-fat meals may delay the absorption of the drug, affecting its onset of action.
• Avoid eating large amounts of chocolate, as it contains a compound that can interact with the medication's metabolism.
• Herbal supplements like St. John's Wort should be used with caution as they may impact the drug's efficacy.
• It is advisable to maintain a balanced diet and stay well-hydrated to support the overall therapeutic effect of the medication.
• Always consult your healthcare provider for personalized advice on food interactions and medication management.

Almitrine, Raubasine Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat sources. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Always check the expiration date on the packaging, and dispose of any expired tablets promptly. Proper disposal is essential; do not flush the tablets or throw them into the garbage. Consult your pharmacist or local waste management authorities for specific guidelines on medication disposal. Keep the tablets out of children's reach to prevent accidental consumption, and ensure that they are stored in a safe and inaccessible place.

Following are the quick tips for Almitrine, Raubasine Tablet:

• Take the tablet as directed by your doctor, typically 1-2 tablets, 3 times a day.
• Ensure you complete the full course of medication as prescribed.
• Take the tablet with a full glass of water to aid swallowing.
• Avoid crushing or chewing the tablet; swallow it whole.
• Maintain a consistent schedule for taking the medication for best results.
• Store the tablets at room temperature, away from moisture and light.
• Inform your doctor if you have any lung or liver problems before taking this medication.